Ultrasound and transdermal drug delivery.

Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis, namely transdermal drug delivery and transdermal monitoring. Particular attention is paid to proposed enhancement mechanisms and future trends in the field of cutaneous vaccination and gene delivery.

[1]  J. Kost,et al.  Rapid Onset of Cutaneous Anesthesia with EMLA Cream After Pretreatment with a New Ultrasound-Emitting Device , 2004, Anesthesia and analgesia.

[2]  A. R. Williams.  Ultrasound : biological effects and potential hazards , 1983 .

[3]  G. Matyas,et al.  Skin immunization made possible by cholera toxin , 1998, Nature.

[4]  Samir Mitragotri,et al.  Interactions of inertial cavitation bubbles with stratum corneum lipid bilayers during low-frequency sonophoresis. , 2003, Biophysical journal.

[5]  S. Mitragotri,et al.  Synergistic effect of low-frequency ultrasound and surfactants on skin permeability. , 2002, Journal of pharmaceutical sciences.

[6]  S. Mitragotri,et al.  Synergistic effect of low-frequency ultrasound and sodium lauryl sulfate on transdermal transport. , 2000, Journal of pharmaceutical sciences.

[7]  T. Ruzicka,et al.  Topical immunomodulators--progress towards treating inflammation, infection, and cancer. , 2001, The Lancet. Infectious diseases.

[8]  Y. Kalia,et al.  Non‐invasive assessment of the effects of iontophoresis on human skin in‐vivo , 2001, The Journal of pharmacy and pharmacology.

[9]  Véronique Préat,et al.  Transdermal Delivery of Macromolecules Using Skin Electroporation , 2004, Pharmaceutical Research.

[10]  A. Edwards,et al.  Acoustic streaming: an in vitro study. , 2003, Ultrasound in medicine & biology.

[11]  Hak Chang,et al.  Ultrasound-Assisted Lipoplasty Treatment for Axillary Bromidrosis:: Clinical Experience of 375 Cases , 2004, Plastic and reconstructive surgery.

[12]  M. Danhof,et al.  In vitro iontophoresis of R-apomorphine across human stratum corneum. Structure-transport relationship of penetration enhancement. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[13]  M. Atobe,et al.  Characterization of transdermal solute transport induced by low-frequency ultrasound in the hairless rat skin. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[14]  J Kost,et al.  Low‐Frequency Sonophoresis: A Noninvasive Method of Drug Delivery and Diagnostics , 2000, Biotechnology progress.

[15]  R. Langer,et al.  Effects of low-frequency ultrasound on the transdermal permeation of mannitol: comparative studies with in vivo and in vitro skin. , 2002, Journal of pharmaceutical sciences.

[16]  R. Guy,et al.  Sonophoresis. II. Examination of the Mechanism(s) of Ultrasound-Enhanced Transdermal Drug Delivery , 1992, Pharmaceutical Research.

[17]  K. Tachibana,et al.  Scanning electron microscopic evaluation of the skin surface after ultrasound exposure , 1997, The Anatomical record.

[18]  C. Foged,et al.  Targeting Vaccines to Dendritic Cells , 2002, Pharmaceutical Research.

[19]  Samir Mitragotri,et al.  Synergistic Effect of Enhancers for Transdermal Drug Delivery , 2000, Pharmaceutical Research.

[20]  Joseph Kost,et al.  Ultrasound-assisted insulin delivery and noninvasive glucose sensing. , 2002, Diabetes technology & therapeutics.

[21]  N. Kollias,et al.  Permeabilization and recovery of the stratum corneum in vivo: The synergy of photomechanical waves and sodium lauryl sulfate , 2001, Lasers in surgery and medicine.

[22]  Kenneth S. Suslick,et al.  Ultrasound: Its Chemical, Physical, and Biological Effects , 1988 .

[23]  S. Mitragotri,et al.  Ultrasound-mediated transdermal protein delivery , 1995, Science.

[24]  J. Uitto,et al.  The genodermatoses: candidate diseases for gene therapy. , 2000, Human gene therapy.

[25]  K. Sugibayashi,et al.  Effect of electric field on the enhanced skin permeation of drugs by electroporation. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[26]  F. Patat,et al.  Effect of sonication parameters on transdermal delivery of insulin to hairless rats. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[27]  S. Mitragotri,et al.  Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis. , 2001, Journal of pharmaceutical sciences.

[28]  M. Prausnitz,et al.  A practical assessment of transdermal drug delivery by skin electroporation. , 1999, Advanced drug delivery reviews.

[29]  Elizabeth Taylor,et al.  Clinical evaluation of a continuous minimally invasive glucose flux sensor placed over ultrasonically permeated skin. , 2004, Diabetes technology & therapeutics.

[30]  M. Allen,et al.  Microfabricated microneedles: a novel approach to transdermal drug delivery. , 1998, Journal of pharmaceutical sciences.

[31]  M. Allen,et al.  Microfabricated microneedles for gene and drug delivery. , 2000, Annual review of biomedical engineering.

[32]  R. Bezemer,et al.  Time to threshold (TT), a safety parameter for heating by diagnostic ultrasound. , 2003, Ultrasound in medicine & biology.

[33]  J Kost,et al.  Analysis of ultrasonically extracted interstitial fluid as a predictor of blood glucose levels. , 2000, Journal of applied physiology.

[34]  G. Vanderstraeten,et al.  Phonophoresis versus topical application of ketoprofen: comparison between tissue and plasma levels. , 2003, Physical therapy.

[35]  Nadine Barrie Smith,et al.  Ultrasound-mediated transdermal in vivo transport of insulin with low-profile cymbal arrays. , 2003, Ultrasound in medicine & biology.

[36]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[37]  J. Fang,et al.  Effect of low frequency ultrasound on the in vitro percutaneous absorption of clobetasol 17-propionate. , 1999, International journal of pharmaceutics.

[38]  R. Newnham,et al.  Short ultrasound exposure times for noninvasive insulin delivery in rats using the lightweight cymbal array , 2004, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[39]  J. Fowlkes,et al.  Section 8 : Clinical relevance , 2000 .

[40]  S. Mitragotri,et al.  Transdermal Delivery of Heparin and Low-Molecular Weight Heparin Using Low-Frequency Ultrasound , 2001, Pharmaceutical Research.

[41]  P. Khavari,et al.  Cutaneous gene transfer for skin and systemic diseases , 2002, Journal of internal medicine.

[42]  L. Babiuk,et al.  Cutaneous vaccination: the skin as an immunologically active tissue and the challenge of antigen delivery. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[43]  Richard H Guy,et al.  Frequency and thermal effects on the enhancement of transdermal transport by sonophoresis. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[44]  D. Roop,et al.  Regulated cutaneous gene delivery: the skin as a bioreactor. , 2000, Human gene therapy.

[45]  J. Hadgraft,et al.  Influence of Ultrasound on the Percutaneous Absorption of Nicotinate Esters , 1991, Pharmaceutical Research.

[46]  K. Tachibana,et al.  Use of Ultrasound to Enhance the Local Anesthetic Effect of Topically Applied Aqueous Lidocaine , 1993, Anesthesiology.

[47]  K. Tachibana,et al.  Transdermal delivery of insulin by ultrasonic vibration , 1991, The Journal of pharmacy and pharmacology.

[48]  Samir Mitragotri,et al.  Transdermal monitoring of glucose and other analytes using ultrasound , 2000, Nature Medicine.

[49]  S. Mitragotri,et al.  Combined Effect of Low-Frequency Ultrasound and Iontophoresis: Applications for Transdermal Heparin Delivery , 2000, Pharmaceutical Research.

[50]  J Kost,et al.  Effect of ultrasound on transdermal drug delivery to rats and guinea pigs. , 1989, The Journal of clinical investigation.

[51]  J. Vogel,et al.  Nonviral skin gene therapy. , 2000, Human gene therapy.

[52]  N. Kollias,et al.  Topical Drug Delivery in Humans with a Single Photomechanical Wave , 1999, Pharmaceutical Research.

[53]  R. Steinman,et al.  The dendritic cell system and its role in immunogenicity. , 1991, Annual review of immunology.

[54]  W. J. Irwin,et al.  Phonophoresis of hydrocortisone with enhancers: an acoustically defined model , 1998 .

[55]  S. Mitragotri,et al.  Transdermal Extraction of Analytes Using Low-Frequency Ultrasound , 2000, Pharmaceutical Research.

[56]  F Patat,et al.  Clinical, histologic, and electron microscopy study of skin exposed to low‐frequency ultrasound , 2001, The Anatomical record.

[57]  G E Trahey,et al.  The use of acoustic streaming in breast lesion diagnosis: a clinical study. , 1999, Ultrasound in medicine & biology.

[58]  Préat,et al.  In vivo efficacy and safety of skin electroporation. , 1999, Advanced drug delivery reviews.

[59]  D. Monti,et al.  Comparison of the effect of ultrasound and of chemical enhancers on transdermal permeation of caffeine and morphine through hairless mouse skin in vitro. , 2001, International journal of pharmaceutics.

[60]  F. T. ten Cate,et al.  Radionuclide tumour therapy with ultrasound contrast microbubbles. , 2004, Ultrasonics.

[61]  L A Crum,et al.  Color Doppler detection of acoustic streaming in a hematoma model. , 2001, Ultrasound in medicine & biology.

[62]  Samir Mitragotri,et al.  Description of transdermal transport of hydrophilic solutes during low-frequency sonophoresis based on a modified porous pathway model. , 2003, Journal of pharmaceutical sciences.

[63]  K. Tachibana.  Transdermal Delivery of Insulin to Alloxan-Diabetic Rabbits by Ultrasound Exposure , 1992, Pharmaceutical Research.

[64]  Samir Mitragotri,et al.  Synergistic Effect of Electric Field and Ultrasound on Transdermal Transport , 1996, Pharmaceutical Research.

[65]  A. Morita,et al.  Roles of Langerhans cells in genetic immunization. , 1999, Journal of dermatological science.

[66]  S. Mitragotri,et al.  Synergistic effects of chemical enhancers and therapeutic ultrasound on transdermal drug delivery. , 1996, Journal of pharmaceutical sciences.

[67]  R. Steinman,et al.  Dendritic Cells Initiate Immune Control of Epstein-Barr Virus Transformation of B Lymphocytes In Vitro , 2003, The Journal of experimental medicine.

[68]  S. Mitragotri,et al.  A mechanistic study of ultrasonically-enhanced transdermal drug delivery. , 1995, Journal of pharmaceutical sciences.

[69]  J. Simonin.  On the mechanisms of in vitro and in vivo phonophoresis , 1995 .

[70]  D. Whaley,et al.  Sonographically guided needle localization after stereotactic breast biopsy. , 2003, AJR. American journal of roentgenology.

[71]  R. Guy,et al.  Sonophoresis. I. The Use of High-Frequency Ultrasound to Enhance Transdermal Drug Delivery , 1992, Pharmaceutical Research.

[72]  F. Patat,et al.  In vitro study of low-frequency ultrasound-enhanced transdermal transport of fentanyl and caffeine across human and hairless rat skin. , 2001, International journal of pharmaceutics.

[73]  R. Leveillee,et al.  Intracorporeal lithotripsy: which modality is best? , 2003, Current opinion in urology.