Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
暂无分享,去创建一个
N. Perrimon | Bahar Yilmazel | Charles Roesel | Yanhui Hu | Richelle Sopko | B. Manning | Shuailiang Lin | B. Housden | Alexander J. Valvezan | Colleen V. Kelley | Michael Buckner | Rong Tao | S. Mohr | Charles L Roesel
[1] W. Talbot,et al. The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily , 1991, Cell.
[2] L. Cherbas,et al. Transformation techniques for Drosophila cell lines. , 1994, Methods in cell biology.
[3] J. Lis,et al. P-TEFb kinase recruitment and function at heat shock loci. , 2000, Genes & development.
[4] B. Dickson,et al. The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation , 2001, Cell.
[5] Gary D Bader,et al. Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants , 2001, Science.
[6] A. Coulson,et al. A functional genomic analysis of cell morphology using RNA interference , 2003, Journal of biology.
[7] Hongbing Zhang,et al. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. , 2003, The Journal of clinical investigation.
[8] Frank B. Golley,et al. Paradigm shift , 1989, Landscape Ecology.
[9] G. Thomas,et al. The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb. , 2004, Novartis Foundation symposium.
[10] D. Kwiatkowski,et al. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. , 2005, Human molecular genetics.
[11] Steven P. Gygi,et al. mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events , 2005, Cell.
[12] C. Proud. Regulation of protein synthesis by insulin. , 2006, Biochemical Society transactions.
[13] P. Crino,et al. The tuberous sclerosis complex. , 2006, The New England journal of medicine.
[14] D. Guertin,et al. Functional Genomics Identifies TOR-Regulated Genes that Control Growth and Division , 2006, Current Biology.
[15] A. Tong,et al. Synthetic genetic array analysis in Saccharomyces cerevisiae. , 2006, Methods in molecular biology.
[16] Seungbok Lee,et al. The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion , 2007, Development.
[17] N. Perrimon,et al. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. , 2007, Gene expression patterns : GEP.
[18] B. Manning,et al. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. , 2008, The Biochemical journal.
[19] Vincent J Schmithorst,et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. , 2008, The New England journal of medicine.
[20] B. Housden,et al. Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic , 2009, Science Signaling.
[21] B. Berger,et al. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. , 2010, Genome research.
[22] R. Jensen,et al. Rapamycin-insensitive up-regulation of MMP2 and other genes in tuberous sclerosis complex 2-deficient lymphangioleiomyomatosis-like cells. , 2010, American journal of respiratory cell and molecular biology.
[23] Wolfgang Huber,et al. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi , 2011, Nature Methods.
[24] J. Krischer,et al. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. , 2011, The New England journal of medicine.
[25] Julian Mintseris,et al. A Protein Complex Network of Drosophila melanogaster , 2011, Cell.
[26] Anne E Carpenter,et al. Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. , 2011, Genome research.
[27] K. Ryan,et al. The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy , 2011, Autophagy.
[28] P. Finan,et al. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. , 2012, Molecular cell.
[29] J. Stockman,et al. Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis , 2012 .
[30] Daniel F. Voytas,et al. Efficient TALEN-mediated gene knockout in livestock , 2012, Proceedings of the National Academy of Sciences.
[31] J. Doudna,et al. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , 2012, Science.
[32] N. Perrimon,et al. Stringent Analysis of Gene Function and Protein–Protein Interactions Using Fluorescently Tagged Genes , 2012, Genetics.
[33] W. Kaelin,et al. Use and Abuse of RNAi to Study Mammalian Gene Function , 2012, Science.
[34] Eli J. Fine,et al. DNA targeting specificity of RNA-guided Cas9 nucleases , 2013, Nature Biotechnology.
[35] David R. Liu,et al. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity , 2013, Nature Biotechnology.
[36] A. Choi,et al. Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide , 2013, Molecular Cancer Research.
[37] Koji Sugiura,et al. Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease , 2013, Nucleic acids research.
[38] Le Cong,et al. Multiplex Genome Engineering Using CRISPR/Cas Systems , 2013, Science.
[39] Susan R. Wente,et al. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system , 2013, Proceedings of the National Academy of Sciences.
[40] Jianzhong Xi,et al. Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9 , 2013, Proceedings of the National Academy of Sciences.
[41] Dong-Yeon Cho,et al. DNA copy number evolution in Drosophila cell lines , 2014, Genome Biology.
[42] Chris P. Ponting,et al. Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System , 2013, Cell reports.
[43] Andrew R. Bassett,et al. Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9 , 2013, Biology Open.
[44] G. Church,et al. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering , 2013, Nature Biotechnology.
[45] Melissa M. Harrison,et al. Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease , 2013, Genetics.
[46] James E. DiCarlo,et al. RNA-Guided Human Genome Engineering via Cas9 , 2013, Science.
[47] Bo Zhang,et al. Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila , 2013, Genetics.
[48] Robert L Sutherland,et al. ZNF300P1 Encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer , 2014, Molecular Cancer.
[49] J. Keith Joung,et al. High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells , 2013, Nature Biotechnology.
[50] B. Dujon,et al. Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast , 2014, PloS one.
[51] Gang Wang,et al. Optimization of Genome Engineering Approaches with the CRISPR/Cas9 System , 2014, PloS one.
[52] Norbert Perrimon,et al. RNAi screening comes of age: improved techniques and complementary approaches , 2014, Nature Reviews Molecular Cell Biology.
[53] Andrew R. Jones,et al. ProteomeXchange provides globally co-ordinated proteomics data submission and dissemination , 2014, Nature Biotechnology.
[54] U. Gaul,et al. Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells , 2014, Nucleic acids research.
[55] Sangsu Bae,et al. Microhomology-based choice of Cas9 nuclease target sites , 2014, Nature Methods.
[56] Jing Li,et al. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells , 2014, The Journal of experimental medicine.
[57] E. Lander,et al. Genetic Screens in Human Cells Using the CRISPR-Cas9 System , 2013, Science.
[58] Neville E. Sanjana,et al. Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells , 2014, Science.
[59] Ying Peng,et al. A simplified and efficient germline-specific CRISPR/Cas9 system for Drosophila genomic engineering , 2013, Fly.
[60] N. Perrimon,et al. Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. , 2014, Developmental cell.
[61] Chris P Ponting,et al. Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System , 2014, Cell reports.
[62] Meagan E. Sullender,et al. Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation , 2014, Nature Biotechnology.
[63] E. Henske,et al. Therapeutic Targeting of Cellular Metabolism in Cells with Hyperactive mTORC1: A Paradigm Shift , 2014, Molecular Cancer Research.
[64] Yanhui Hu,et al. Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila. , 2014, Cell reports.
[65] E. Roach,et al. Tuberous sclerosis complex. , 2015, Handbook of clinical neurology.
[66] V. Cowling,et al. Myc and mRNA capping☆ , 2015, Biochimica et biophysica acta.