RNA trafficking in myelinating cells

In the past year, several key molecular components of the RNA trafficking pathway in myelinating cells have been identified: distinct cis-acting elements for RNA transport and localization have been characterized in myelin basic protein mRNA; hnRNP A2 has been identified as a trans-acting factor in oligodendrocytes that binds specifically to the RNA transport sequence; and microtubules and kinesin have been identified as cytoskeletal elements required for RNA transport in oligodendrocytes.

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