Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative

[1]  F. Reyes,et al.  PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A , 2015, The Journal of Antibiotics.

[2]  D. Sherman,et al.  Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743. , 2015, Environmental microbiology.

[3]  Michael A Fischbach,et al.  Computational approaches to natural product discovery. , 2015, Nature chemical biology.

[4]  Carla S. Jones,et al.  Minimum Information about a Biosynthetic Gene cluster. , 2015, Nature chemical biology.

[5]  M. Sánchez-Hidalgo,et al.  Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway , 2015, Chembiochem : a European journal of chemical biology.

[6]  G. Challis,et al.  Discovery of microbial natural products by activation of silent biosynthetic gene clusters , 2015, Nature Reviews Microbiology.

[7]  Kai Blin,et al.  antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters , 2015, Nucleic Acids Res..

[8]  Rodrigo Lopez,et al.  The EMBL-EBI bioinformatics web and programmatic tools framework , 2015, Nucleic Acids Res..

[9]  Y. Wen,et al.  A MarR Family Transcriptional Regulator, DptR3, Activates Daptomycin Biosynthesis and Morphological Differentiation in Streptomyces roseosporus , 2015, Applied and Environmental Microbiology.

[10]  V. Schramm,et al.  Structural and Biochemical Characterization of Chlamydia trachomatis Hypothetical Protein CT263 Supports That Menaquinone Synthesis Occurs through the Futalosine Pathway* , 2014, The Journal of Biological Chemistry.

[11]  Prafull Ranadive,et al.  Caerulomycin A—An Antifungal Compound Isolated from Marine Actinomycetes , 2014 .

[12]  E. Balskus,et al.  Lomaiviticin biosynthesis employs a new strategy for starter unit generation. , 2014, Organic letters.

[13]  T. Begley,et al.  Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme. , 2013, Journal of the American Chemical Society.

[14]  A. Kajdacsy-Balla,et al.  Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells , 2013, Evidence-based complementary and alternative medicine : eCAM.

[15]  Tae-Jin Oh,et al.  Advantages of Single-Molecule Real-Time Sequencing in High-GC Content Genomes , 2013, PloS one.

[16]  D. Sherman,et al.  Diversity of P450 enzymes in the biosynthesis of natural products. , 2012, Natural product reports.

[17]  J. Imhoff,et al.  Langkolide, a 32-membered macrolactone antibiotic produced by Streptomyces sp. Acta 3062. , 2012, Journal of natural products.

[18]  J. Martín,et al.  LAL Regulators SCO0877 and SCO7173 as Pleiotropic Modulators of Phosphate Starvation Response and Actinorhodin Biosynthesis in Streptomyces coelicolor , 2012, PloS one.

[19]  Young Ji Yoo,et al.  Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities , 2012, Applied Microbiology and Biotechnology.

[20]  A. Pineda-Lucena,et al.  Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin in Streptomyces lydicus: Tailoring Modification of 3-Methyl-Aspartate , 2011, Journal of bacteriology.

[21]  Margherita Sosio,et al.  Antibiotic discovery in the twenty-first century: current trends and future perspectives , 2010, The Journal of Antibiotics.

[22]  M. Goodfellow,et al.  A guide to successful bioprospecting: informed by actinobacterial systematics , 2010, Antonie van Leeuwenhoek.

[23]  S. Koren,et al.  Assembly algorithms for next-generation sequencing data. , 2010, Genomics.

[24]  Carlos Olano,et al.  Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. , 2010, Natural product reports.

[25]  D. Newman,et al.  Microbial antitumor drugs: natural products of microbial origin as anticancer agents. , 2009, Current opinion in investigational drugs.

[26]  T. Dairi.  An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains , 2009, The Journal of Antibiotics.

[27]  Peter Man-Un Ung,et al.  Automated genome mining for natural products , 2009, BMC Bioinformatics.

[28]  Carlos Olano,et al.  Antitumor Compounds from Marine Actinomycetes , 2009, Marine drugs.

[29]  W. D. de Vos,et al.  Microbial Cell Factories Heme and Menaquinone Induced Electron Transport in Lactic Acid Bacteria , 2022 .

[30]  Priyanka Verma,et al.  Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis , 2009, Nature chemical biology.

[31]  Trygve Brautaset,et al.  Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei. , 2008, Chemistry & biology.

[32]  J. Zucko,et al.  ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures , 2008, Nucleic acids research.

[33]  R. H. Baltz.  Renaissance in antibacterial discovery from actinomycetes. , 2008, Current opinion in pharmacology.

[34]  Jun Ishikawa,et al.  An Alternative Menaquinone Biosynthetic Pathway Operating in Microorganisms , 2008, Science.

[35]  C. Méndez,et al.  Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering. , 2008, Metabolic engineering.

[36]  J. Pernodet,et al.  Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens. , 2007, Microbiology.

[37]  Rodrigo Lopez,et al.  Clustal W and Clustal X version 2.0 , 2007, Bioinform..

[38]  A. Driessen,et al.  Distribution and Physiology of ABC-Type Transporters Contributing to Multidrug Resistance in Bacteria , 2007, Microbiology and Molecular Biology Reviews.

[39]  J. Martín,et al.  PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis. , 2007, Microbiology.

[40]  J. Roe,et al.  Dual Role of OhrR as a Repressor and an Activator in Response to Organic Hydroperoxides in Streptomyces coelicolor , 2007, Journal of bacteriology.

[41]  Heinz G Floss,et al.  Combinatorial biosynthesis--potential and problems. , 2006, Journal of biotechnology.

[42]  Nagamani Bora,et al.  Diversity and biogeography of marine actinobacteria. , 2006, Current opinion in microbiology.

[43]  Won Seok Jung,et al.  Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae. , 2006, Journal of natural products.

[44]  S. Kehraus,et al.  Natural Products from Marine Organisms and Their Associated Microbes , 2006, Chembiochem : a European journal of chemical biology.

[45]  D. Rai,et al.  Biosynthesis of Amphotericin Derivatives Lacking Exocyclic Carboxyl Groups* , 2005, Journal of Biological Chemistry.

[46]  H. Laatsch,et al.  A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108. , 2005, Chemistry & biology.

[47]  James R. Knight,et al.  Genome sequencing in microfabricated high-density picolitre reactors , 2005, Nature.

[48]  H. Yoshiji,et al.  Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo. , 2005, International journal of oncology.

[49]  J. Thorson,et al.  The hedamycin locus implicates a novel aromatic PKS priming mechanism. , 2004, Chemistry & biology.

[50]  G. Carter,et al.  Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp. , 2004, Journal of natural products.

[51]  P. Leadlay,et al.  Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation † , 2004, Molecular microbiology.

[52]  Taek Soon Lee,et al.  Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. , 2003, Biochemistry.

[53]  Gitanjali Yadav,et al.  Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases. , 2003, Journal of molecular biology.

[54]  G. Schwartz,et al.  Bryostatin-1: A Novel PKC Inhibitor in Clinical Development , 2003, Cancer investigation.

[55]  K. Reynolds,et al.  The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase. , 2002, Chemistry & biology.

[56]  F. Schluenzen,et al.  Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria , 2001, Nature.

[57]  S. Fish,et al.  The tylosin-biosynthetic genes of Streptomyces fradiae , 2001, Antonie van Leeuwenhoek.

[58]  J. Martín,et al.  Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis. , 2001, Chemistry & biology.

[59]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[60]  Alan T. Bull,et al.  Search and Discovery Strategies for Biotechnology: the Paradigm Shift , 2000, Microbiology and Molecular Biology Reviews.

[61]  P. Leadlay,et al.  A chain initiation factor common to both modular and aromatic polyketide synthases , 1999, Nature.

[62]  K. Dimitriadis,et al.  Optimization of the sulforhodamine B colorimetric assay. , 1997, Journal of immunological methods.

[63]  L M Cañedo,et al.  Thiocoraline, a novel depsipeptide with antitumor activity produced by a marine Micromonospora. II. Physico-chemical properties and structure determination. , 1997, The Journal of antibiotics.

[64]  Thomas L. Madden,et al.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.

[65]  W. Jin,et al.  [Structure determination of new antifungal antibiotics, polaramycins A and B]. , 1997, Yao xue xue bao = Acta pharmaceutica Sinica.

[66]  H. Koshino,et al.  Liposidolide A, a new antifungal macrolide antibiotic. , 1995, The Journal of antibiotics.

[67]  K. O'Brien,et al.  Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. , 1992, Gene.

[68]  P. Leadlay,et al.  6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme. , 1992, European journal of biochemistry.

[69]  D. Scudiero,et al.  New colorimetric cytotoxicity assay for anticancer-drug screening. , 1990, Journal of the National Cancer Institute.

[70]  D. Hanahan,et al.  Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[71]  T. Dairi.  Menaquinone biosyntheses in microorganisms. , 2012, Methods in enzymology.

[72]  Micheal C. Wilson,et al.  Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. , 2012, Natural product reports.

[73]  J. Martín,et al.  Cascades and networks of regulatory genes that control antibiotic biosynthesis. , 2012, Sub-cellular biochemistry.

[74]  D. Heinz,et al.  Unusual carbon fixation gives rise to diverse polyketide extender units. , 2011, Nature chemical biology.

[75]  C. Méndez,et al.  Chapter 11. Sugar biosynthesis and modification. , 2009, Methods in enzymology.

[76]  T. Kieser.  Practical streptomyces genetics , 2000 .