Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

Structural and biophysical studies reveal how CaMKII kinases, which are important for cellular learning and memory, are switched on by binding of Ca2+/calmodulin.

[1]  John Kuriyan,et al.  Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation , 2010, Nature Structural &Molecular Biology.

[2]  M. Wilmanns,et al.  Molecular Basis of the Death-Associated Protein Kinase–Calcium/Calmodulin Regulator Complex , 2010, Science Signaling.

[3]  C. Kallenberg,et al.  Role for CaMKII Inhibition in Rheumatoid Arthritis , 2009, Annals of the New York Academy of Sciences.

[4]  Nan Li,et al.  Endogenous Human CaMKII Inhibitory Protein Suppresses Tumor Growth by Inducing Cell Cycle Arrest and Apoptosis through Down-regulation of the Phosphatidylinositide 3-Kinase/Akt/HDM2 Pathway* , 2009, The Journal of Biological Chemistry.

[5]  Steven S. Vogel,et al.  Structural rearrangement of CaMKIIα catalytic domains encodes activation , 2009, Proceedings of the National Academy of Sciences.

[6]  J. M. Bradshaw,et al.  Role of the N- and C-lobes of calmodulin in the activation of Ca(2+)/calmodulin-dependent protein kinase II. , 2008, Biochemistry.

[7]  Yuyang Sun,et al.  Ca2+/Calmodulin-dependent Protein Kinase II-dependent Remodeling of Ca2+ Current in Pressure Overload Heart Failure* , 2008, Journal of Biological Chemistry.

[8]  P. Bork,et al.  Linear Motif Atlas for Phosphorylation-Dependent Signaling , 2008, Science Signaling.

[9]  M. Anderson,et al.  The role of calmodulin kinase II in myocardial physiology and disease. , 2008, Physiology.

[10]  M. Waxham,et al.  Ca2+/Calmodulin-dependent Protein Kinases , 2008, Cellular and Molecular Life Sciences.

[11]  Mark E. Anderson,et al.  A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation , 2008, Cell.

[12]  Nan Li,et al.  A Novel Endogenous Human CaMKII Inhibitory Protein Suppresses Tumor Growth by Inducing Cell Cycle Arrest via p27 Stabilization* , 2008, Journal of Biological Chemistry.

[13]  Leslie C. Griffith,et al.  Activity-Dependent Gating of CaMKII Autonomous Activity by Drosophila CASK , 2006, Neuron.

[14]  P. Brown,et al.  Macromolecular size-and-shape distributions by sedimentation velocity analytical ultracentrifugation. , 2006, Biophysical journal.

[15]  A. Nairn,et al.  Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II , 2006, The FEBS journal.

[16]  M. Swindells,et al.  Erratum: Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca2+/calmodulin- dependent kinase kinase peptide (Journal of Molecular Biology (2001) 312 (59-68) DOI: 10.1006/jmbi.2001.4822) , 2005 .

[17]  Angus C. Nairn,et al.  Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme , 2005, Cell.

[18]  Randy J Read,et al.  Electronic Reprint Biological Crystallography Likelihood-enhanced Fast Translation Functions Biological Crystallography Likelihood-enhanced Fast Translation Functions , 2022 .

[19]  K. Giese,et al.  Mouse Genetic Approaches to Investigating Calcium/Calmodulin-Dependent Protein Kinase II Function in Plasticity and Cognition , 2004, The Journal of Neuroscience.

[20]  Leslie C. Griffith Regulation of Calcium/Calmodulin-Dependent Protein Kinase II Activation by Intramolecular and Intermolecular Interactions , 2004, The Journal of Neuroscience.

[21]  M. Waxham,et al.  RC3/Neurogranin and Ca2+/Calmodulin-dependent Protein Kinase II Produce Opposing Effects on the Affinity of Calmodulin for Calcium* , 2004, Journal of Biological Chemistry.

[22]  G. Ming,et al.  A CaMKII/Calcineurin Switch Controls the Direction of Ca2+-Dependent Growth Cone Guidance , 2004, Neuron.

[23]  Dan Wang,et al.  Comparative Analyses of the Three-dimensional Structures and Enzymatic Properties of α, β, γ, and δ Isoforms of Ca2+-Calmodulin-dependent Protein Kinase II* , 2004, Journal of Biological Chemistry.

[24]  P. Schuck A model for sedimentation in inhomogeneous media. I. Dynamic density gradients from sedimenting co-solutes. , 2004, Biophysical chemistry.

[25]  C. Lu,et al.  Regulation of the Ca2+/CaM-Responsive Pool of CaMKII by Scaffold-Dependent Autophosphorylation , 2003, Neuron.

[26]  R. Malenka The long-term potential of LTP , 2003, Nature Reviews Neuroscience.

[27]  J. Cleaver Cambridge Laboratory of Molecular Biology , 2003, Science.

[28]  Angus C Nairn,et al.  Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. , 2003, Molecular cell.

[29]  T. Hunter,et al.  The Protein Kinase Complement of the Human Genome , 2002, Science.

[30]  Karl Peter Giese,et al.  Inhibitory Autophosphorylation of CaMKII Controls PSD Association, Plasticity, and Learning , 2002, Neuron.

[31]  M Ikura,et al.  Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca(2+)/calmodulin-dependent kinase kinase peptide. , 2001, Journal of molecular biology.

[32]  M. Waxham,et al.  Three-dimensional Reconstructions of Calcium/Calmodulin-dependent (CaM) Kinase IIα and Truncated CaM Kinase IIα Reveal a Unique Organization for Its Structural Core and Functional Domains* , 2000, The Journal of Biological Chemistry.

[33]  S. Shenolikar,et al.  Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. , 1998, Science.

[34]  Alcino J. Silva,et al.  Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. , 1998, Science.

[35]  G. Murshudov,et al.  Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.

[36]  A. Rhoads,et al.  Sequence motifs for calmodulin recognition , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[37]  E. Kandel,et al.  Control of Memory Formation Through Regulated Expression of a CaMKII Transgene , 1996, Science.

[38]  L. Johnson,et al.  Active and Inactive Protein Kinases: Structural Basis for Regulation , 1996, Cell.

[39]  A. Nairn,et al.  Structural Basis for the Autoinhibition of Calcium/Calmodulin-Dependent Protein Kinase I , 1996, Cell.

[40]  F. Quiocho,et al.  X-ray analysis reveals conformational adaptation of the linker in functional calmodulin mutants , 1995, Nature Structural Biology.

[41]  Chi-Ying F. Huang,et al.  Identification of the Substrate and Pseudosubstrate Binding Sites of Phosphorylase Kinase γ-Subunit (*) , 1995, The Journal of Biological Chemistry.

[42]  B. Kemp,et al.  Insights into autoregulation from the crystal structure of twitchin kinase , 1994, Nature.

[43]  H. Schulman,et al.  Identification and characterization of δB-CaM kinase and δC-CaM kinase from rat heart, two new multifunctional Ca2+/calmodulin-dependent protein kinase isoforms , 1994 .

[44]  R. Colbran,et al.  Inactivation of Ca2+/calmodulin-dependent protein kinase II by basal autophosphorylation. , 1993, The Journal of biological chemistry.

[45]  H. Schulman,et al.  Inhibitory autophosphorylation of multifunctional Ca2+/calmodulin-dependent protein kinase analyzed by site-directed mutagenesis. , 1992, The Journal of biological chemistry.

[46]  A. Edelman,et al.  Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain. II. Enzymatic characteristics and regulation of activities by phosphorylation and dephosphorylation. , 1992, The Journal of biological chemistry.

[47]  H. Schulman,et al.  Calmodulin Trapping by Calcium-Calmodulin-Dependent Protein Kinase , 1992, Science.

[48]  M. Kennedy,et al.  Activation of type II calcium/calmodulin-dependent protein kinase by Ca2+/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin-binding domain. , 1990, The Journal of biological chemistry.

[49]  H Fujisawa,et al.  Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs. , 1989, The Journal of biological chemistry.

[50]  R. Tsien,et al.  Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. , 1989, Science.

[51]  R. Nicoll,et al.  An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation , 1989, Nature.

[52]  M K Smith,et al.  Regulatory domain of calcium/calmodulin-dependent protein kinase II. Mechanism of inhibition and regulation by phosphorylation. , 1989, The Journal of biological chemistry.

[53]  M. King,et al.  Affinity labeling of the ATP-binding site of type II calmodulin-dependent protein kinase by 5'-p-fluorosulfonylbenzoyl adenosine. , 1988, Archives of biochemistry and biophysics.

[54]  T. Soderling,et al.  Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains. , 1988, The Journal of biological chemistry.

[55]  Stephen G. Miller,et al.  Sequences of autophosphorylation sites in neuronal type II CaM kinase that control Ca2+-independent activity , 1988, Neuron.

[56]  T. Soderling,et al.  Autophosphorylation of Ca2+/calmodulin-dependent protein kinase II. Effects on total and Ca2+-independent activities and kinetic parameters. , 1987, The Journal of biological chemistry.

[57]  M. Kennedy,et al.  Regulation of brain Type II Ca 2+ calmodulin -dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch , 1986, Cell.

[58]  M. Kennedy,et al.  Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat brain , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[59]  P. J. Vernon,et al.  Autophosphorylation of Calmodulin‐Kinase II in Synaptic Junctions Modulates Endogenous Kinase Activity , 1984, Journal of neurochemistry.

[60]  G. Siegal,et al.  alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression. , 2007, Laboratory investigation; a journal of technical methods and pathology.

[61]  John M Koomen,et al.  Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. , 2004, The Journal of biological chemistry.

[62]  Andy Hudmon,et al.  Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function. , 2002, Annual review of biochemistry.

[63]  H. Schulman,et al.  Identification and characterization of delta B-CaM kinase and delta C-CaM kinase from rat heart, two new multifunctional Ca2+/calmodulin-dependent protein kinase isoforms. , 1994, Biochimica et biophysica acta.

[64]  T. Yamauchi,et al.  [Ca2(+)-calmodulin-dependent protein kinase II]. , 1990, Seikagaku. The Journal of Japanese Biochemical Society.

[65]  H. Fujisawa,et al.  Tissue-specific expression of mRNAs for three distinct types of rat calmodulin-dependent protein kinase II , 1989 .