Scanning in biomedical imaging: from classical devices to handheld heads and micro-systems

We review some of the most important scanning systems that are competitive in high-end biomedical imaging applications such as Optical Coherence Tomography (OCT), but also Confocal Microscopy (CM) or multiphoton microscopy. Both 1-D (uni-dimensional) and 2-D (bi-dimensional) scanning systems are considered. The paper discusses different scanners, including polygon mirror, galvanometer-based and Risley prisms. Their configurations and characteristics, as well some of our contributions in the domain are presented. The tendency of applying them into special designs such as handheld scanning probes and endoscopes – the latter with MEMS (Micro-Electro-Mechanical Systems) and micro-systems is pointed out. A discussion on further advancements of scanning technology in biomedical applications in general and in OCT in particular concludes the study.

[1]  S. Yun,et al.  115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser. , 2005, Optics letters.

[2]  A. Morosawa,et al.  Spectral narrowing effect by quasi-phase continuous tuning in high-speed wavelength-swept light source. , 2008, Optics express.

[3]  J. Schuman,et al.  Optical coherence tomography. , 2000, Science.

[4]  S. Yun,et al.  High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter. , 2003, Optics letters.

[5]  Virgil-Florin Duma On-line measurements with optical scanners: metrological aspects , 2005, SPIE Optical Metrology.

[6]  Virgil-Florin Duma,et al.  Theoretical approach on a galvanometric scanner with an enhanced duty cycle , 2008, Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics.

[7]  J. Fujimoto,et al.  Buffered Fourier domain mode locking: Unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s. , 2006, Optics letters.

[8]  S. Motaghian Nezam High-speed polygon-scanner-based wavelength-swept laser source in the telescope-less configurations with application in optical coherence tomography. , 2008, Optics letters.

[9]  Yajun Li,et al.  Beam deflection and scanning by two-mirror and two-axis systems of different architectures: a unified approach. , 2008, Applied optics.

[10]  V. F. Duma,et al.  Command functions of open loop galvanometer scanners with optimized duty cycles , 2012 .

[11]  Jeehyun Kim,et al.  Handheld Optical Coherence Tomography Scanner for Primary Care Diagnostics , 2011, IEEE Transactions on Biomedical Engineering.

[12]  Y Li,et al.  Asymmetric distribution of the scanned field of a rotating reflective polygon. , 1997, Applied optics.

[13]  Virgil-Florin Duma,et al.  Neutral density filters with Risley prisms: analysis and design. , 2009, Applied optics.

[14]  J. S. Gadhok,et al.  Achieving high-duty cycle sawtooth scanning with galvanometric scanners , 1999, Optics & Photonics.

[15]  Yaguang Yang Analytic Solution of Free Space Optical Beam Steering Using Risley Prisms , 2008, Journal of Lightwave Technology.

[16]  C T Walters Flat-field postobjective polygon scanner. , 1995, Applied optics.

[17]  Hyungsuck Cho,et al.  Active optical system for variable view imaging of micro objects with emphasis on kinematic analysis. , 2008, Applied optics.

[18]  Gerald F. Marshall,et al.  Handbook of Optical and Laser Scanning , 2004 .

[19]  Gerald F. Marshall,et al.  Advances in oscillatory optical scanners , 1995, Photonics West.

[20]  Johannes F de Boer,et al.  Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans. , 2012, Optics express.

[21]  Gerald F. Marshall,et al.  Risley prism scan patterns , 1999, Optics & Photonics.

[22]  Yajun Li Single-mirror beam steering system: analysis and synthesis of high-order conic-section scan patterns. , 2008, Applied optics.

[23]  Jan Awrejcewicz Modeling, Simulation and Control of Nonlinear Engineering Dynamical Systems , 2009 .

[24]  Virgil-Florin Duma,et al.  Optimal scanning function of a galvanometer scanner for an increased duty cycle , 2010 .

[25]  Jun Xie,et al.  Correction of the image distortion for laser galvanometric scanning system , 2005 .

[26]  William C Warger,et al.  Dual-wedge scanning confocal reflectance microscope. , 2007, Optics letters.

[27]  Nanguang Chen,et al.  Double-reflection polygon mirror for high-speed optical coherence microscopy. , 2007, Optics letters.

[28]  Virgil-Florin Duma,et al.  Modeling of Risley prisms devices for exact scan patterns , 2013, Optical Metrology.

[29]  Virgil-Florin Duma,et al.  Mathematical Functions of a 2-D Scanner with Oscillating Elements , 2009 .

[30]  P. So,et al.  High-speed, two-photon scanning microscope. , 1999, Applied optics.

[31]  Virgil-Florin Duma,et al.  Driving solutions and optomechanical design of scanners with Risley prisms , 2014, International Conference on Lasers in Medicine.

[32]  Adrian Gh. Podoleanu,et al.  Perspectives of optical scanning in OCT , 2010, BiOS.

[33]  Adrian Bradu,et al.  Dual instrument for in vivo and ex vivo OCT imaging in an ENT department , 2012, Biomedical optics express.

[34]  Iwona Gorczynska,et al.  Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera. , 2009, Optics express.

[35]  N. Munce,et al.  High-power wavelength-swept laser in Littman telescope-less polygon filter and dual-amplifier configuration for multichannel optical coherence tomography. , 2009, Optics letters.

[36]  Virgil-Florin Duma,et al.  Numerical and experimental study of the characteristic functions of polygon scanners , 2009, Optical Metrology.

[37]  Michael N. Sweeney Polygon scanners revisited , 1997, Optics & Photonics.

[38]  Leo Beiser Design equations for a polygon laser scanner , 1991, Electronic Imaging.

[39]  Jannick P. Rolland,et al.  Mechanical Constraints and Design Considerations for Polygon Scanners , 2010 .

[40]  Ki-Hun Jeong,et al.  Forward imaging OCT endoscopic catheter based on MEMS lens scanning. , 2012, Optics letters.

[41]  Jean Montagu Scanners: Galvanometric and Resonant , 2015 .

[42]  Redmond P. Aylward,et al.  Advanced galvanometer‐based optical scanner design , 2003 .

[43]  Daniel L Marks,et al.  Fast-Fourier-domain delay line for in vivo optical coherence tomography with a polygonal scanner. , 2003, Applied optics.

[44]  S. M. R. Motaghian Nezam High-speed polygon-scanner-based wavelength-swept laser source in the telescope-less configurations with application in optical coherence tomography. , 2008 .

[45]  Virgil-Florin Duma,et al.  Experimental investigations of the scanning functions of galvanometer-based scanners with applications in OCT. , 2011, Applied optics.

[46]  Bruce E. Rohr Testing high-performance galvanometer-based optical scanners , 1995, Photonics West.

[47]  L. Yannuzzi,et al.  Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy. , 2004, Journal of biomedical optics.

[48]  Michael Bass,et al.  Handbook of optics , 1995 .

[49]  Virgil-Florin Duma,et al.  Optimization of scanning and command functions of galvanometer-based scanners , 2011, Optical Metrology.

[50]  Virgil-Florin Duma Novel approaches in the designing of the polygon scanners , 2007, ROMOPTO International Conference on Micro- to Nano- Photonics.

[51]  Adrian Gh. Podoleanu,et al.  Polygon mirror scanners in biomedical imaging: a review , 2013, Photonics West - Optoelectronic Materials and Devices.