Estrogens for men: Good or bad news

The role of estrogens in male physiology has received little attention until recently. However, it is now becoming more and more evident that estrogens are jar more important for a normal junction of reproduction and non-reproductive junctions in men than supposed. Furthermore, although estrogen has been discussed in the context of a decline in sperm number in men, there are no unequivocal data allowing any conclusion on a negative impact of environmental estrogens on male fertility so jar.

[1]  K. Korach,et al.  Endothelial dysfunction in a man with disruptive mutation in oestrogen-receptor gene , 1997, The Lancet.

[2]  V. Papadopoulos,et al.  Printed in U.S.A. Copyright © 1997 by The Endocrine Society Regulation of Rat Testis Gonocyte Proliferation by Platelet-Derived Growth Factor and Estradiol: Identification of Signaling Mechanisms Involved* , 2022 .

[3]  E. Nieschlag,et al.  Declining sperm counts in European men—fact or fiction? , 2009, Andrologia.

[4]  F. Comhaire,et al.  Declining sperm quality in European men , 2009, Andrologia.

[5]  J. Auger,et al.  Declining sperm counts? More research is needed , 2009, Andrologia.

[6]  P. Palego,et al.  Declining sperm counts in Italy during the past 20 years , 2009, Andrologia.

[7]  B C Gladen,et al.  Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. , 1996, Endocrinology.

[8]  M. Joffe.  Decreased fertility in Britain compared with Finland , 1996, The Lancet.

[9]  R. Sharpe,et al.  Expression of cytochrome P450 17alpha-hydroxylase/C17-20 lyase in the fetal rat testis is reduced by maternal exposure to exogenous estrogens. , 1996, Endocrinology.

[10]  E. Simpson,et al.  Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. , 1995, The Journal of clinical endocrinology and metabolism.

[11]  W. Yue,et al.  Human testicular aromatase: immunocytochemical and biochemical studies. , 1995, The Journal of clinical endocrinology and metabolism.

[12]  K. Korach,et al.  Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. , 1994, The New England journal of medicine.

[13]  Bruce S. McEwen,et al.  Estradiol and progesterone regulate neuronal structure and synaptic connectivity in adult as well as developing brain , 1994, Experimental Gerontology.

[14]  W. Bremner,et al.  Physiological levels of estradiol stimulate plasma high density lipoprotein2 cholesterol levels in normal men. , 1994, The Journal of clinical endocrinology and metabolism.

[15]  K. Korach,et al.  Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[16]  R. M. Sharpe,et al.  Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? , 1993, The Lancet.

[17]  R M Sharpe,et al.  Declining sperm counts in men--is there an endocrine cause? , 1993, The Journal of endocrinology.

[18]  N. Skakkebaek,et al.  The human testis--an organ at risk? , 1992, International journal of andrology.

[19]  M. F. Etreby,et al.  Role of estrogens and androgens for the negative feedback control of gonadotropin secretion in different species , 1992 .

[20]  W. Crowley,et al.  Neuroendocrine control of human reproduction in the male. , 1991, Recent progress in hormone research.

[21]  Robert E. Jones,et al.  High-density lipoprotein cholesterol is not decreased if an aromatizable androgen is administered. , 1990, Metabolism: clinical and experimental.

[22]  L. Perkins,et al.  Intratesticular site of aromatase activity and possible function of testicular estradiol , 1987, Steroids.

[23]  C. Roselli,et al.  The distribution and regulation of aromatase activity in the central nervous system , 1987, Steroids.

[24]  S. Winters,et al.  Evidence for a role of endogenous estrogen in the hypothalamic control of gonadotropin secretion in men. , 1985, The Journal of clinical endocrinology and metabolism.

[25]  L. Gooren,et al.  Estrogens in the Feedback Regulation of Gonadotropin Secretion in Men: Effects of Administration of Estrogen to Agonadal Subjects and the Antiestrogen Tamoxifen and the Aromatase Inhibitor δ‘‐Testolactone to Eugonadal Subjects , 2009, Andrologia.

[26]  R. Falvo,et al.  Regulation of gonadotropin secretion in the male dog. Role of estradiol. , 1983, Journal of andrology.

[27]  F. de Jong,et al.  Development and cellular localization of rat testicular aromatase activity. , 1982, Journal of reproduction and fertility.

[28]  R. Kelch,et al.  Intratesticular site of aromatization in the human. , 1976, The Journal of clinical endocrinology and metabolism.

[29]  D. Armstrong,et al.  Follicle-stimulating hormone stimulates estradiol-17beta synthesis in cultured Sertoli cells. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[30]  K. Gräf,et al.  Hormone-induced disturbances in sexual differentiation. , 1974, Advances in the biosciences.