Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55.
暂无分享,去创建一个
E. Groman | V. M. Holers | D. Simberg | S. Moghimi | Guankui Wang | R. Scheinman | D. Backos | V. Vu | Donald S. Backos | N. Banda | Geoffrey B. Gifford | Geoffrey Gifford | V. Holers
[1] Seyed Moein Moghimi,et al. Immunoglobulin deposition on biomolecule corona determines complement opsonisation efficiency of preclinical and clinical nanoparticles , 2018, Nature Nanotechnology.
[2] Yechezkel Barenholz,et al. Roadmap and strategy for overcoming infusion reactions to nanomedicines , 2018, Nature Nanotechnology.
[3] A. Alawieh,et al. Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice , 2018, Science Translational Medicine.
[4] G. Arrigoni,et al. C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes. , 2018, ACS nano.
[5] D. Simberg,et al. Translational gaps in animal models of human infusion reactions to nanomedicines. , 2018, Nanomedicine.
[6] S. Moghimi. Nanomedicine safety in preclinical and clinical development: focus on idiosyncratic injection/infusion reactions. , 2017, Drug discovery today.
[7] E. Groman,et al. Variability of Complement Response toward Preclinical and Clinical Nanocarriers in the General Population. , 2017, Bioconjugate chemistry.
[8] S. Barnum. Therapeutic Inhibition of Complement: Well Worth the Risk. , 2017, Trends in pharmacological sciences.
[9] Seyed Moein Moghimi,et al. Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo. , 2017, Nature nanotechnology.
[10] John D Lambris,et al. Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation. , 2017, Blood.
[11] Yan Wang,et al. Stealth Immune Properties of Graphene Oxide Enabled by Surface-Bound Complement Factor H. , 2016, ACS nano.
[12] Guangwei Yang,et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome , 2016, Haematologica.
[13] A. Gabizon,et al. New insights and evolving role of pegylated liposomal doxorubicin in cancer therapy. , 2016, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[14] S. Alzghari,et al. Meta-analysis of clinical and preclinical studies comparing the anticancer efficacy of liposomal versus conventional non-liposomal doxorubicin. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[15] John D Lambris,et al. Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode , 2016, The EMBO journal.
[16] A. Risitano,et al. Safety and Pharmacokinetics of the Complement Inhibitor TT30 in a Phase I Trial for Untreated PNH Patients , 2015 .
[17] B. Paul Morgan,et al. Complement, a target for therapy in inflammatory and degenerative diseases , 2015, Nature Reviews Drug Discovery.
[18] V. M. Holers,et al. Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake. , 2015, ACS nano.
[19] T. Triche,et al. Activity of MM-398, Nanoliposomal Irinotecan (nal-IRI), in Ewing's Family Tumor Xenografts Is Associated with High Exposure of Tumor to Drug and High SLFN11 Expression , 2015, Clinical Cancer Research.
[20] Seyed Moein Moghimi,et al. Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum , 2014, Particle and Fibre Toxicology.
[21] S. Russek,et al. High-relaxivity superparamagnetic iron oxide nanoworms with decreased immune recognition and long-circulating properties. , 2014, ACS nano.
[22] S M Moghimi,et al. Cancer nanomedicine and the complement system activation paradigm: anaphylaxis and tumour growth. , 2014, Journal of controlled release : official journal of the Controlled Release Society.
[23] John D Lambris,et al. Mediation of a non-proteolytic activation of complement component C3 by phospholipid vesicles. , 2014, Biomaterials.
[24] John D Lambris,et al. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria. , 2014, Blood.
[25] S. Katti,et al. The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer models and acts by CR2-dependent targeting of CR1 regulatory activity , 2012 .
[26] Davoud Ahmadvand,et al. Material properties in complement activation. , 2011, Advanced drug delivery reviews.
[27] Kutty Selva Nandakumar,et al. Inhibiting the C5-C5a receptor axis. , 2011, Molecular immunology.
[28] D. Simberg,et al. Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems , 2011, Expert opinion on drug delivery.
[29] Jin Wu,et al. Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation , 2010, Science.
[30] John D Lambris,et al. Complement: a key system for immune surveillance and homeostasis , 2010, Nature Immunology.
[31] Parag Aggarwal,et al. Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. , 2008, Molecular pharmaceutics.
[32] B. Nilsson,et al. The tick-over theory revisited: formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb). , 2008, Molecular immunology.
[33] V. M. Holers,et al. A Complement C3 Inhibitor Specifically Targeted to Sites of Complement Activation Effectively Ameliorates Collagen-Induced Arthritis in DBA/1J Mice1 , 2007, The Journal of Immunology.
[34] R. Weissleder,et al. Utility of a new bolus-injectable nanoparticle for clinical cancer staging. , 2007, Neoplasia.
[35] Janos Szebeni,et al. Methylation of the phosphate oxygen moiety of phospholipid‐methoxy(polyethylene glycol) conjugate prevents PEGylated liposome‐mediated complement activation and anaphylatoxin production , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[36] M. Teixeira,et al. APT070 (Mirococept), a membrane‐localised complement inhibitor, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury , 2005, British journal of pharmacology.
[37] G. Smith,et al. Biological activity, membrane‐targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli , 2004, Protein science : a publication of the Protein Society.
[38] P Lukacik,et al. Complement regulation at the molecular level: the structure of decay-accelerating factor. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[39] F M Muggia,et al. Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil): possible role in hypersensitivity reactions. , 2003, Annals of oncology : official journal of the European Society for Medical Oncology.
[40] G. Smith,et al. Membrane-targeted complement inhibitors. , 2001, Molecular immunology.
[41] A. Gabizon. Pegylated Liposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form of Chemotherapy , 2001, Cancer investigation.
[42] C. Mold,et al. Structure/function studies of human decay‐accelerating factor , 2000, Immunology.
[43] D. Fairlie,et al. Effects of a new C5a receptor antagonist on C5a‐ and endotoxin‐ induced neutropenia in the rat , 1999, British journal of pharmacology.
[44] K. Dimock,et al. Short Consensus Repeat Domain 1 of Decay-Accelerating Factor Is Required for Enterovirus 70 Binding , 1998, Journal of Virology.
[45] R. V. van Lier,et al. The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF) , 1996, The Journal of experimental medicine.
[46] C. Mold,et al. Localization of classical and alternative pathway regulatory activity within the decay-accelerating factor. , 1996, Journal of immunology.
[47] R. Smith,et al. Overexpression in Escherichia coli, folding, purification, and characterization of the first three short consensus repeat modules of human complement receptor type 1. , 1995, Protein expression and purification.
[48] L. Matis,et al. Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation. , 1995, The Journal of clinical investigation.
[49] D. Hourcade,et al. Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis. , 1994, The Journal of biological chemistry.
[50] T. Fujita,et al. Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor. , 1992, Journal of immunology.
[51] J. Lambris,et al. Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H. , 1985, The Biochemical journal.
[52] T. Lint,et al. Activation of human complement by liposomes: a model for membrane activation of the alternative pathway. , 1979, Journal of immunology.
[53] A. Lundberg,et al. The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models , 2019, Molecular immunology.
[54] Jennifer I. Hare,et al. Challenges and strategies in anti-cancer nanomedicine development: An industry perspective. , 2017, Advanced drug delivery reviews.
[55] F. Wandosell,et al. ImmunoPEGliposome-mediated reduction of blood and brain amyloid levels in a mouse model of Alzheimer's disease is restricted to aged animals. , 2017, Biomaterials.
[56] V. Holers,et al. CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation. , 2013, Advances in experimental medicine and biology.
[57] M. Bodó,et al. The interaction of liposomes with the complement system: in vitro and in vivo assays. , 2003, Methods in enzymology.