Rational Domain Swaps Reveal Insights about Chain Length Control by Ketosynthase Domains in Fungal Nonreducing Polyketide Synthases
暂无分享,去创建一个
[1] Shu-Lin Chang,et al. An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans. , 2013, Journal of the American Chemical Society.
[2] C. Townsend,et al. Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products. , 2013, Angewandte Chemie.
[3] Shu-Lin Chang,et al. Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans. , 2012, Journal of the American Chemical Society.
[4] N. Kelleher,et al. Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. , 2012, Journal of the American Chemical Society.
[5] R. Cox,et al. Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite. , 2011, Journal of the American Chemical Society.
[6] Clay C C Wang,et al. Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans. , 2011, Journal of the American Chemical Society.
[7] A. Davidson,et al. A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. , 2009, Journal of the American Chemical Society.
[8] C. Townsend,et al. Synthetic Strategy of Nonreducing Iterative Polyketide Synthases and the Origin of the Classical “Starter‐Unit Effect” , 2008, Chembiochem : a European journal of chemical biology.
[9] N. Kelleher,et al. Deconstruction of Iterative Multidomain Polyketide Synthase Function , 2008, Science.
[10] Chu-Young Kim,et al. Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. , 2007, Chemistry & biology.
[11] Clay C C Wang,et al. Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. , 2007, Journal of the American Chemical Society.
[12] Yue Ma,et al. Catalytic Relationships between Type I and Type II Iterative Polyketide Synthases: The Aspergillus parasiticus Norsolorinic Acid Synthase , 2006, Chembiochem : a European journal of chemical biology.
[13] Chu-Young Kim,et al. The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase , 2006 .
[14] S. Osmani,et al. A Versatile and Efficient Gene-Targeting System for Aspergillus nidulans , 2006, Genetics.
[15] Chaitan Khosla,et al. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. , 2002, Structure.
[16] Daniel W. Udwary,et al. A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase. , 2002, Journal of molecular biology.
[17] A. Watanabe,et al. A novel hexaketide naphthalene synthesized by a chimeric polyketide synthase composed of fungal pentaketide and heptaketide synthases , 2002 .
[18] R. Cox,et al. First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determination. , 2003, Chemical communications.