The Logistic Organ Dysfunction System

The assessment of the severity of organ dysfunction in the ICU is a critical tool for conducting clinical trials, especially sepsis trials. The evaluation of new therapies cannot be successfully achieved without controlling for the degree of organ dysfunction. It is not adequate to assess severity, or to describe a patient’s condition, by simply counting the number of dysfunctioning organ systems.

[1]  S. Lemeshow,et al.  Modeling the severity of illness of ICU patients. A systems update. , 1994, JAMA.

[2]  W. Knaus,et al.  Prognosis for Recovery from Multiple Organ system failure , 1990, Medical decision making : an international journal of the Society for Medical Decision Making.

[3]  S Lemeshow,et al.  The Logistic Organ Dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group. , 1996, JAMA.

[4]  W. Sibbald,et al.  Round table conference on clinical trials for the treatment of sepsis. , 1995, Critical care medicine.

[5]  J. Singer,et al.  A simple multiple system organ failure scoring system predicts mortality of patients who have sepsis syndrome. , 1993, Chest.

[6]  C. Sprung,et al.  Multiple Organ Dysfunction Score , 1996 .

[7]  Arthur S Slutsky,et al.  Multiple system organ failure. Is mechanical ventilation a contributing factor? , 1998, American journal of respiratory and critical care medicine.

[8]  D. Pittet,et al.  The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. , 1995, JAMA.

[9]  J. Marshall,et al.  The microbiology of multiple organ failure. The proximal gastrointestinal tract as an occult reservoir of pathogens. , 1988, Archives of surgery.

[10]  W. Cleveland.  Robust Locally Weighted Regression and Smoothing Scatterplots , 1979 .

[11]  J. Hanley,et al.  The meaning and use of the area under a receiver operating characteristic (ROC) curve. , 1982, Radiology.

[12]  J. Border.  Multiple systems organ failure. , 1992, Critical care clinics.

[13]  S. Lemeshow,et al.  A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. , 1993, JAMA.

[14]  L. Stevens.  Gauging the severity of surgical sepsis. , 1983, Archives of surgery.

[15]  E. Draper,et al.  Prognosis in Acute Organ‐System Failure , 1985, Annals of surgery.

[16]  R. L. Fulton,et al.  Multiple system organ failure. The role of uncontrolled infection. , 1980, Archives of surgery.

[17]  David W. Hosmer,et al.  Applied Logistic Regression , 1991 .

[18]  J. Bion,et al.  A comparison of severity of illness scoring systems for intensive care unit patients: results of a multicenter, multinational study. The European/North American Severity Study Group. , 1995, Critical care medicine.

[19]  Corinne Alberti,et al.  The Logistic Organ Dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group. , 1996, JAMA.

[20]  C. Sprung,et al.  Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. , 1995, Critical care medicine.