The discovery of 7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor.
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B. Davies | M. Vázquez‐Chantada | G. Lamont | A. Ramos-Montoya | E. Cadogan | M. Finlay | G. Wrigley | B. Williamson | M. Howard | Frederick W. Goldberg | C. Fallan | D. Beattie | D. Barratt | E. Dean | A. Ting | M. Schimpl | F. Goldberg | M. Vázquez-Chantada | Gillian M. Lamont