Neural processing associated with true and false memory retrieval

We investigated the neural bases for false memory with fMRI by examining neural activity during retrieval processes that yielded true or false memories. We used a reality monitoring paradigm in which participants saw or imagined pictures of concrete objects. (A subsequent misinformation task was also used to increase false memory rates.) At test, fMRI data were collected as the participants determined whether they had seen or had only imagined the object at study. True memories were of seen pictures accurately endorsed as seen, and for false memories were of imagined pictures falsely endorsed as seen. Three distinct patterns of activity were observed: Left frontal and parietal activity was not different for true and for false memories, whereas activity was greater for true than for false memories in occipital visual regions and posterior portions of the parahippocampal gyrus, and activity was greater for false than for true memories in right anterior cingulate gyrus. Possible interpretations are discussed.

[1]  R. Buckner,et al.  Functional Dissociation among Components of Remembering: Control, Perceived Oldness, and Content , 2003, The Journal of Neuroscience.

[2]  R. Dolan,et al.  Differential activation of the prefrontal cortex in successful and unsuccessful memory retrieval. , 1996, Brain : a journal of neurology.

[3]  H. Soininen,et al.  MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. , 1998, AJNR. American journal of neuroradiology.

[4]  Marcia K. Johnson,et al.  Fact and fantasy: The effects of internally generated events on the apparent frequency of externally generated events , 1977, Memory & cognition.

[5]  E. Loftus,et al.  Reconstruction of automobile destruction: An example of the interaction between language and memory , 1974 .

[6]  J P Rosenfeld,et al.  P300 latency, but not amplitude or topography, distinguishes between true and false recognition. , 2001, Journal of experimental psychology. Learning, memory, and cognition.

[7]  J. Deese.  On the prediction of occurrence of particular verbal intrusions in immediate recall. , 1959, Journal of experimental psychology.

[8]  Jason P. Mitchell,et al.  The Seven Sins of Memory , 2003, Annals of the New York Academy of Sciences.

[9]  E. Kandel,et al.  Cognitive Neuroscience and the Study of Memory , 1998, Neuron.

[10]  E L Wilding,et al.  Electrophysiological evidence for dissociable processes contributing to recollection. , 1998, Acta psychologica.

[11]  E. Loftus,et al.  The Formation of False Memories , 1995 .

[12]  S. Petersen,et al.  Memory's echo: vivid remembering reactivates sensory-specific cortex. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[13]  R. Cabeza,et al.  Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies , 2000, Journal of Cognitive Neuroscience.

[14]  T. Penney,et al.  Event related brain potentials and illusory memories: the effects of differential encoding. , 2001, Brain research. Cognitive brain research.

[15]  D. Schacter,et al.  Functional–Anatomic Study of Episodic Retrieval Using fMRI I. Retrieval Effort versus Retrieval Success , 1998, NeuroImage.

[16]  L. Mannucci,et al.  Chemical Stimulation of Synaptosomes Modulates α-Ca2+/Calmodulin-Dependent Protein Kinase II mRNA Association to Polysomes , 2000, The Journal of Neuroscience.

[17]  Jonathan D. Cohen,et al.  Conflict monitoring versus selection-for-action in anterior cingulate cortex , 1999, Nature.

[18]  A. Dale,et al.  Late Onset of Anterior Prefrontal Activity during True and False Recognition: An Event-Related fMRI Study , 1997, NeuroImage.

[19]  E. Loftus,et al.  On the permanence of stored information in the human brain. , 1980, The American psychologist.

[20]  C. Stark,et al.  Making Memories without Trying: Medial Temporal Lobe Activity Associated with Incidental Memory Formation during Recognition , 2003, The Journal of Neuroscience.

[21]  A. Dale,et al.  Functional–Anatomic Study of Episodic Retrieval II. Selective Averaging of Event-Related fMRI Trials to Test the Retrieval Success Hypothesis , 1998, NeuroImage.

[22]  Daniel L. Schacter,et al.  Neuroanatomical Correlates of Veridical and Illusory Recognition Memory: Evidence from Positron Emission Tomography , 1996, Neuron.

[23]  Marcia K. Johnson,et al.  Cognitive and brain mechanisms of false memories and beliefs. , 2000 .

[24]  Monica Fabiani,et al.  True But Not False Memories Produce a Sensory Signature in Human Lateralized Brain Potentials , 2000, Journal of Cognitive Neuroscience.

[25]  E. Tulving.  Memory and consciousness. , 1985 .

[26]  D. Schacter.  The seven sins of memory. Insights from psychology and cognitive neuroscience. , 1999, The American psychologist.

[27]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[28]  Ken A. Paller,et al.  Neural events that underlie remembering something that never happened , 2000, Nature Neuroscience.

[29]  E F Loftus,et al.  Semantic integration of verbal information into a visual memory. , 1978, Journal of experimental psychology. Human learning and memory.

[30]  Craig E. L. Stark,et al.  When zero is not zero: The problem of ambiguous baseline conditions in fMRI , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Alan C. Evans,et al.  Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images: considering the variability of the collateral sulcus. , 2002, Cerebral cortex.

[32]  J. Desmond,et al.  Prefrontal cortex and recognition memory. Functional-MRI evidence for context-dependent retrieval processes. , 1998, Brain : a journal of neurology.

[33]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[34]  Marcia K. Johnson,et al.  Left Anterior Prefrontal Activation Increases with Demands to Recall Specific Perceptual Information , 2000, The Journal of Neuroscience.

[35]  T. Shallice,et al.  Recollection and Familiarity in Recognition Memory: An Event-Related Functional Magnetic Resonance Imaging Study , 1999, The Journal of Neuroscience.

[36]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[37]  M. Farah.  The neural basis of mental imagery , 1989, Trends in Neurosciences.

[38]  M. Johnson,et al.  Source monitoring and memory distortion. , 1997, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[39]  K. McDermott,et al.  Creating false memories: Remembering words not presented in lists. , 1995 .

[40]  L. Squire,et al.  Functional Magnetic Resonance Imaging (fMRI) Activity in the Hippocampal Region during Recognition Memory , 2000, The Journal of Neuroscience.

[41]  H. Eichenbaum,et al.  The Neurophysiology of Memory , 2000, Annals of the New York Academy of Sciences.

[42]  S. Kosslyn,et al.  The role of area 17 in visual imagery: convergent evidence from PET and rTMS. , 1999, Science.

[43]  D. Schacter,et al.  The cognitive neuroscience of constructive memory. , 1998, Annual review of psychology.

[44]  M. McCloskey,et al.  Misleading postevent information and memory for events: arguments and evidence against memory impairment hypotheses. , 1985, Journal of experimental psychology. General.

[45]  L. Squire,et al.  Simple and associative recognition memory in the hippocampal region. , 2001, Learning & memory.

[46]  D. Schacter,et al.  Can medial temporal lobe regions distinguish true from false? An event-related functional MRI study of veridical and illusory recognition memory , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[47]  Marcia K. Johnson,et al.  Fact and fantasy: the roles of accuracy and variability in confusing imaginations with perceptual experiences. , 1979 .