The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(alpha) pyrene.

[1]  J. Selkirk,et al.  High-pressure liquid chromatographic separation of 10 benzo(a)pyrene phenols and the identification of 1-phenol and 7-phenol as new metabolites. , 1976, Cancer research.

[2]  C. Widnell,et al.  Response of NADPH cytochrome c reductase and cytochrome P-450 in hepatic microsomes to treatment with phenobarbital--differences in rat strains. , 1975, Biochemical pharmacology.

[3]  S. Orrenius,et al.  Characterization of a rat lung microsomal fraction obtained by sepharose 2B ultrafiltration. , 1975, Cancer research.

[4]  M. Correia,et al.  Effect of cobalt on microsomal cytochrome P-450: differences between liver and intestinal mucosa. , 1975, Biochemical and biophysical research communications.

[5]  A. Y. Lu,et al.  Metabolism of benzo[a]pyrene. III. An evaluation of the fluorescence assay. , 1975, Biochemical and biophysical research communications.

[6]  H. Gelboin,et al.  Aryl hydrocarbon (benzo[a]pyrene) hydroxylases in liver from rats of different age, sex and nutritional status. Distinction of two types by 7,8-benzoflavone. , 1975, Biochemical pharmacology.

[7]  M. Marselos,et al.  Starvation and phenobarbital treatment effects on drug hydroxylation and glucuronidation in the rat liver and small intestinal mucosa. , 1975, Biochemical pharmacology.

[8]  S. Orrenius,et al.  The metabolism of benzo(alpha)pyrene in isolated rat liver cells. , 1975, Cancer research.

[9]  C. Woo,et al.  Cytochrome P-450 and drug metabolism in intestinal villous and crypt cells of rats: effect of dietary iron. , 1975, Biochemical and biophysical research communications.

[10]  J. Selkirk,et al.  Isolation by high pressure liquid chromatography and characterization of benzo(a)pyrene-4'5-epoxide as a metobolite of benzoapyrene. , 1975, Archives of biochemistry and biophysics.

[11]  H. Vainio,et al.  Inducibility of mucosal drug-metabolizing enzymes of rats fed on a cholesterol-rich diet by polychlorinated biphenyl, 3-methylcholanthrene and phenobarbitone. , 1975, Pharmacology.

[12]  J. Fouts,et al.  A comparative study of xenobiotic-metabolizing enzymes in liver and intestine of various animal species. , 1974, Drug metabolism and disposition: the biological fate of chemicals.

[13]  V. Ullrich,et al.  In vitro induction by phenobarbital of drug monooxygenase activity in mouse isolated small intestine. , 1974, Biochemical pharmacology.

[14]  J. Selkirk,et al.  Benzo[a]pyrene Metabolites: Efficient and Rapid Separation by High-Pressure Liquid Chromatography , 1974, Science.

[15]  O. Hänninen,et al.  Variable activities of drug-metabolizing enzymes in the gut of the rat after feeding with different pelleted diets , 1974 .

[16]  A. Mclean,et al.  The effect of dietary protein and fat on the activity of aryl hydrocarbon hydroxylase in rat liver, kidney and lung. , 1973, Biochemical pharmacology.

[17]  N. Zampaglione,et al.  Properties of benzpyrene hydroxylase in the liver, intestinal mucosa and adrenal of untreated and 3-methylcholanthrene-treated rats. , 1973, The Journal of pharmacology and experimental therapeutics.

[18]  W. Dehnen,et al.  A modified method for the assay of benzo(a)pyrene hydroxylase. , 1973, Analytical biochemistry.

[19]  D. Parke,et al.  The influence of some hepatic enzyme inducers and inhibitors on extrahepatic drug metabolism. , 1973, Drug metabolism and disposition: the biological fate of chemicals.

[20]  H. Vainio,et al.  Enhancement of drug oxidation and conjugation by carcinogens in different rat tissues , 1972, FEBS letters.

[21]  E. di Salle,et al.  Daily rhythmic variation and liver drug metabolism in rats. , 1971, Biochemical pharmacology.

[22]  L. Wattenberg.  Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer: Effect of diet on benzpyrene hydroxylase activity , 1971, Cancer.

[23]  Y. Imai,et al.  Evidence for two forms of P-450 hemoprotein in microsomal membranes. , 1966, Biochemical and biophysical research communications.

[24]  H. Gelboin,et al.  THE STIMULATORY EFFECT OF 3-METHYLCHOLANTHRENE ON BENZPYRENE HYDROXYLASE ACTIVITY IN SEVERAL RAT TISSUES: INHIBITION BY ACTINOMYCIN D AND PUROMYCIN. , 1964, Cancer research.

[25]  L. Wattenberg,et al.  Benzpyrene hydroxylase activity in the gastrointestinal tract. , 1962, Cancer research.

[26]  F. Bertalanffy.  Mitotic rates and renewal times of the digestive tract epithelia in the rat. , 1960, Acta anatomica.

[27]  J. Miller,et al.  Substrate-induced synthesis and other properties of benzpyrene hydroxylase in rat liver. , 1957, The Journal of biological chemistry.

[28]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.