Vegetation Optical Depth (VOD) plays an increasingly important role in studying global carbon, water and energy transformation [1], [2]. This study explores the performance of the X-MEB (X-band microwave emission of the biosphere) model at global scale. Similar to the L-MEB model, the X-MEB model, built by INRAE (Institut national de recherche pour l'agriculture, l'alimentation et l'environnement) Bordeaux, aims to retrieve VOD (referred to as IB X-VOD) at X-band. To avoid the ill-posed problem caused by retrieving two parameters of interest (soil moisture (SM) and VOD) from mono-angular and dual-polarized observations (AMSR2), which are strongly correlated, we used the ERA5 SM product as an input to the X-MEB inversion. At a first step, we produced global IB X-VOD in year 2015 using the parameters (soil roughness and effective scattering albedo) calibrated in the African continent and evaluated the retrieved X-VOD with three vegetation parameters including Above-Ground Biomass (AGB), Leaf Area Index (LAI) and Normalized Difference Vegetation Index (NDVI). The evaluation results indicate X-MEB model has a great potential for global VOD retrievals from AMSR2 satellite data.