Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology
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F. Verhey | M. Verbeek | H. Jacobs | Joost M. Riphagen | W. Freeze | B. Hanseeuw | I. Ramakers | Linda H. G. Pagen
[1] D. Rizopoulos,et al. Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study , 2019, Journal of Neuroinflammation.
[2] J. Williamson,et al. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial , 2019, JAMA.
[3] John X. Morris,et al. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction , 2018, Nature Medicine.
[4] D. Holtzman,et al. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight , 2018, Nature Reviews Immunology.
[5] P. Tariot,et al. Randomized Trial of Verubecestat for Mild‐to‐Moderate Alzheimer's Disease , 2018, The New England journal of medicine.
[6] A. Loudon,et al. Clocking in to immunity , 2018, Nature Reviews Immunology.
[7] M. Mintun,et al. Trial of Solanezumab for Mild Dementia Due to Alzheimer's Disease , 2018, The New England journal of medicine.
[8] Tim Clark,et al. Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease , 2018, Proceedings of the National Academy of Sciences.
[9] B. Zlokovic,et al. Alzheimer’s disease: A matter of blood–brain barrier dysfunction? , 2017, The Journal of experimental medicine.
[10] C. Held,et al. Inflammatory Biomarkers Interleukin‐6 and C‐Reactive Protein and Outcomes in Stable Coronary Heart Disease: Experiences From the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial , 2017, Journal of the American Heart Association.
[11] A. Fagan,et al. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy , 2017, Nature.
[12] Markus Glatzel,et al. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. , 2017, Immunity.
[13] W. M. Palm,et al. Pericortical Enhancement on Delayed Postgadolinium Fluid-Attenuated Inversion Recovery Images in Normal Aging, Mild Cognitive Impairment, and Alzheimer Disease , 2017, American Journal of Neuroradiology.
[14] D. Holtzman,et al. Glial contributions to neurodegeneration in tauopathies , 2017, Molecular Neurodegeneration.
[15] K. Blennow,et al. Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype , 2017, Neurobiology of Aging.
[16] W. M. van der Flier,et al. Low normal cerebrospinal fluid Aβ42 levels predict clinical progression in nondemented subjects , 2017, Annals of neurology.
[17] L. Collins-Praino,et al. Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury? , 2017, Brain, Behavior, and Immunity.
[18] S. Rose-John,et al. The role of interleukin-6 signaling in nervous tissue. , 2016, Biochimica et biophysica acta.
[19] B. Zlokovic,et al. Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[20] Sterling C. Johnson,et al. Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation , 2015, Alzheimer's & dementia.
[21] R. Hollingsworth,et al. Interleukin-6 Stimulates Defective Angiogenesis. , 2015, Cancer research.
[22] D. Y. Lee,et al. Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. , 2015, JAMA.
[23] C. Iadecola,et al. Dangerous Leaks: Blood-Brain Barrier Woes in the Aging Hippocampus , 2015, Neuron.
[24] R. Sperling,et al. Subjective cognitive concerns, episodic memory, and the APOE ε4 allele , 2014, Alzheimer's & Dementia.
[25] L. Kuller,et al. Arterial stiffness and β-amyloid progression in nondemented elderly adults. , 2014, JAMA neurology.
[26] M. Humbert,et al. Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension , 2014, Circulation.
[27] Nick C Fox,et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. , 2014, The New England journal of medicine.
[28] R. Ransohoff,et al. Development, maintenance and disruption of the blood-brain barrier , 2013, Nature Network Boston.
[29] C. Iadecola. The Pathobiology of Vascular Dementia , 2013, Neuron.
[30] M. Miller,et al. Sample Size Requirements for Structural Equation Models , 2013, Educational and psychological measurement.
[31] D. Blacker,et al. The role of peripheral inflammatory markers in dementia and Alzheimer's disease: a meta-analysis. , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.
[32] Berislav V. Zlokovic,et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A , 2012, Nature.
[33] B. Zlokovic. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders , 2011, Nature Reviews Neuroscience.
[34] Nick C Fox,et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.
[35] J. Morris,et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.
[36] G. Bu,et al. Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in an in Vitro Blood-Brain Barrier Model* , 2011, The Journal of Biological Chemistry.
[37] G. Hansson,et al. The immune system in atherosclerosis , 2011, Nature Immunology.
[38] N. Herrmann,et al. A Meta-Analysis of Cytokines in Alzheimer's Disease , 2010, Biological Psychiatry.
[39] Cindee M. Madison,et al. Comparing predictors of conversion and decline in mild cognitive impairment , 2010, Neurology.
[40] F. Jessen,et al. Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment. , 2010, Archives of general psychiatry.
[41] Ilona B. Bruinsma,et al. Apolipoprotein E protects cultured pericytes and astrocytes from D-Aβ1–40-mediated cell death , 2010, Brain Research.
[42] J. Trojanowski,et al. Total and phosphorylated tau protein as biological markers of Alzheimer’s disease , 2010, Experimental Gerontology.
[43] W. Bowers,et al. Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice. , 2009, The American journal of pathology.
[44] V. Seyfert-Margolis,et al. Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays , 2009, BMC Immunology.
[45] Sirkka Goebeler,et al. Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age , 2009, Annals of neurology.
[46] D. Thal,et al. Cerebral Small Vessel Disease-Induced Apolipoprotein E Leakage Is Associated With Alzheimer Disease and the Accumulation of Amyloid &bgr;-Protein in Perivascular Astrocytes , 2008, Journal of neuropathology and experimental neurology.
[47] A. Fagan,et al. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. , 2007, Archives of neurology.
[48] Bin Zhang,et al. Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model , 2007, Neuron.
[49] T. Miida,et al. Serum amyloid A (SAA)-induced remodeling of CSF-HDL. , 2006, Biochimica et biophysica acta.
[50] F. LaFerla,et al. Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease , 2005, The Journal of Neuroscience.
[51] R. Maccioni,et al. Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. , 2004, Experimental cell research.
[52] K. Hagihara,et al. IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system. , 2004, Biochemical and biophysical research communications.
[53] J W Rowe,et al. Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging , 2002, Neurology.
[54] J. Manson,et al. Systolic and Diastolic Blood Pressure, Pulse Pressure, and Mean Arterial Pressure as Predictors of Cardiovascular Disease Risk in Men , 2000, Hypertension.
[55] L. Bouter,et al. Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition. , 1999, The American journal of psychiatry.
[56] Shaobo Zhang,et al. Sample size in factor analysis. , 1999 .
[57] S. Rose-John,et al. Role of IL-6 and the soluble IL-6 receptor in inhibition of VCAM-1 gene expression. , 1998, Journal of immunology.
[58] C. Duyckaerts,et al. ApoE immunoreactivity and microglial cells in Alzheimer's disease brain , 1995, Neuroscience Letters.
[59] J. D. L. Torre. Impaired brain microcirculation may trigger Alzheimer's disease , 1994, Neuroscience & Biobehavioral Reviews.
[60] H. Wiśniewski,et al. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[61] Jessica L. Larson,et al. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. , 2017, Journal of Alzheimer's disease : JAD.
[62] T. Wyss-Coray,et al. Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. , 2012, Cold Spring Harbor perspectives in medicine.
[63] K. Blennow,et al. Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease. , 2011, Journal of Alzheimer's disease : JAD.
[64] M. Carrillo,et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011 .
[65] Hartwig Wolburg,et al. Choroid plexus: biology and pathology , 2009, Acta Neuropathologica.
[66] B. Muthén,et al. TEACHER ’ S CORNER How to Use a Monte Carlo Study to Decide on Sample Size and Determine Power , 2002 .
[67] G. Trinchieri. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. , 1995, Annual review of immunology.
[68] K. Blennow,et al. Protein analysis in cerebrospinal fluid. II. Reference values derived from healthy individuals 18-88 years of age. , 1993, European neurology.
[69] K. Blennow,et al. Protein Analysis in Cerebrospinal Fluid , 1993 .