Combinatorial ‘library on bead’ approach to polymeric materials with vastly enhanced chiral recognition

A general screening method for enantiomer recognition is introduced for the rapid preparation of novel chiral stationary phases for HPLC in which libraries of mixed chiral selectors are immobilized on polymer beads and the resulting chiral phases tested in the separation of racemic targets followed by deconvolution to afford an optimized separation medium.

[1]  F. Švec,et al.  Polar, Monodisperse, Reactive Beads from Functionalized Methacrylate Monomers by Staged Templated Suspension Polymerization , 1998 .

[2]  J. Fréchet,et al.  Polymer- versus silica-based separation media: elimination of nonspecific interactions in the chiral recognition process through functional polymer design. , 1997, Analytical chemistry.

[3]  C. Welch,et al.  Some thoughts on the coupling of dissimilar chiral columns or the mixing of chiral stationary phases for the separation of enantiomers , 1996 .

[4]  P. Schultz.  Lessons from the Immune System: From Catalysis to Materials , 1996 .

[5]  R. Carbonell,et al.  Affinity purification of proteins using ligands derived from peptide libraries , 1995, Biotechnology and bioengineering.

[6]  D. Armstrong,et al.  Macrocyclic Antibiotics as a New Class of Chiral Selectors for Liquid Chromatography , 1994 .

[7]  P. Murray,et al.  Chiral stationary phase design: Use of intercalative effects to enhance enantioselectivity , 1993 .

[8]  William H. Pirkle,et al.  Considerations of chiral recognition relevant to the liquid chromatography separation of enantiomers , 1989 .

[9]  D. Armstrong,et al.  Cyclodextrin Bonded Phases For the Liquid Chromatographic Separation of Optical, Geometrical, and Structural Isomers , 1984 .

[10]  H. Borén,et al.  Direct liquid chromatographic separation of enantiomers on immobilized protein stationary phases : III. Optical resolution of a series of N-aroyl d,l-amino acids by high-performance liquid chromatography on bovine serum albumin covalently bound to silica , 1983 .