EndoTOFPET-US a novel multimodal tool for endoscopy and Positron Emission Tomography

The EndoTOFPET-US project aims to jointly exploit Time-Of-Flight Positron Emission Tomography (TOFPET) and ultrasound endoscopy with a multi-modal instrument for the development of new biomarkers for pancreas and prostate oncology. The paper outlines the functionality of the proposed instrument and the challenges for its realization. The high level of miniaturization and integration poses strong demands to the fields of scintillating crystallography, ultra-fast photon detection, highly integrated electronics and system integration. Solutions are presented to obtain a coincidence time resolution better than 200 ps and a spatial resolution of -1 mm with an asymmetric TOFPET detector. A tracking system with better than 1 mm spatial resolution precision enables the online alignment of the system. The detector design, the production and test status of the single detector components, and the integration plans are discussed.

[1]  E. Charbon,et al.  Multi-channel digital SiPMs: Concept, analysis and implementation , 2012, 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC).

[2]  Tobias Harion,et al.  STiC - A mixed mode chip for SiPM ToF applications , 2012, 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC).

[3]  D. Schaart,et al.  The lower bound on the timing resolution of scintillation detectors , 2012, Physics in medicine and biology.

[4]  Erika Garutti,et al.  Single channel optimization for an endoscopic time-of-flight positron emission tomography detector , 2011, 2011 IEEE Nuclear Science Symposium Conference Record.

[5]  P. Jarron,et al.  NINO: an ultrafast low-power front-end amplifier discriminator for the time-of-flight detector in the ALICE experiment , 2004, IEEE Transactions on Nuclear Science.

[6]  W. S. Monkhouse,et al.  GRAY'S ANATOMY , 1947 .

[7]  Edoardo Charbon,et al.  System Tradeoffs in Gamma-Ray Detection Utilizing SPAD Arrays and Scintillators , 2010, IEEE Transactions on Nuclear Science.

[8]  Shingo Mandai,et al.  A fully-integrated 780×800μm2 multi-digital silicon photomultiplier with column-parallel time-to-digital converter , 2012, 2012 Proceedings of the ESSCIRC (ESSCIRC).

[9]  C. R. Rao,et al.  Information and the Accuracy Attainable in the Estimation of Statistical Parameters , 1992 .

[10]  C Lartizien,et al.  GATE: a simulation toolkit for PET and SPECT. , 2004, Physics in medicine and biology.

[11]  M. Paganoni,et al.  Design and performance of detector modules for the endoscopic PET probe for the FP7-project EndoTOFPET-US , 2012, 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC).