Aerosol bolus dispersion in healthy subjects.

Aerosol bolus dispersion is a physiological test of lungs, which uses monodisperse submicron particles to measure intrapulmonary convective gas mixing. In this study, aerosol bolus dispersion was measured in healthy subjects in order to assess reference values for possible clinical applications, to assess the reproducibility of these values, and to identify physical and physiological factors influencing aerosol bolus dispersion. Aerosol bolus dispersion was measured in 79 healthy subjects using 20 cm3 aerosol boluses consisting of monodisperse di-2-ethylhexyl sebacate (DEHS) particles. The reproducibility of parameters characterizing the width of the exhaled bolus was of the same order as that of parameters of the flow-volume curve (10%). Aerosol bolus dispersion was independent of the level of lung inflation, and the slope of the relationship between flow rate and dispersion was on average not significantly different from zero (range 100-700 cm3.s-1). Multiple linear regression showed that aerosol bolus dispersion increased with increasing total lung capacity of the subject. We conclude that differences in total lung capacity between individuals should be taken into account when using measures of aerosol bolus dispersion for possible clinical applications.

[1]  J. Heyder,et al.  Influence of intrinsic particle properties on the assessment of convective gas transport by aerosol bolus technique. , 1996, Experimental lung research.

[2]  M Paiva,et al.  Two- and three-dimensional simulations of aerosol transport and deposition in alveolar zone of human lung. , 1996, Journal of applied physiology.

[3]  James D. Blanchard,et al.  Aerosol Bolus Dispersion and Aerosol-Derived Airway Morphometry: Assessment of Lung Pathology and Response to Therapy, Part 2 , 1996 .

[4]  J. Blanchard.  Aerosol bolus dispersion and aerosol-derived airway morphometry: assessment of lung pathology and response to therapy, Part 1. , 1996, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[5]  J. Heyder,et al.  Aerosol derived airway morphometry in healthy subjects. , 1995, The European respiratory journal.

[6]  T. Tuch,et al.  Aerosol bolus dispersion and effective airway diameters in mildly asthmatic children. , 1995, The European respiratory journal.

[7]  F. Rosenthal.  Aerosol deposition and dispersion characterize lung injury in a canine model of emphysema. , 1995, Journal of applied physiology.

[8]  H. Wichmann,et al.  Detection of early lung impairment with aerosol bolus dispersion. , 1994, The European respiratory journal.

[9]  D. Edwards.  A general theory of the macrotransport of nondepositing particles in the lung by convective dispersion , 1994 .

[10]  T. Tuch,et al.  Aerosol bolus dispersion in the respiratory tract of children. , 1994, Experimental lung research.

[11]  J E Cotes,et al.  Lung volumes and forced ventilatory flows , 1993, European Respiratory Journal.

[12]  F. Rosenthal.  The Effect of Nonuniform Ventilation on the Dispersion of Inspired Aerosol Boluses—A Modeling Study , 1993 .

[13]  W. Bennett,et al.  The effect of ozone exposure on the dispersion of inhaled aerosol boluses in healthy human subjects. , 1991, The American review of respiratory disease.

[14]  J K Briant,et al.  Flow distribution through human and canine airways during inhalation and exhalation. , 1989, Journal of applied physiology.

[15]  J. Heyder,et al.  Effect of cystic fibrosis on inhaled aerosol boluses. , 1989, The American review of respiratory disease.

[16]  J. Heyder,et al.  Convective mixing in human respiratory tract: estimates with aerosol boli. , 1988, Journal of applied physiology.

[17]  J. Heyder,et al.  The Use of Light Scattering Photometry in Aerosol Medicine , 1988 .

[18]  Engel La,et al.  Gas Mixing and Distribution in the Lung , 1985 .

[19]  T. Amis,et al.  Regional ventilation distribution , 1985 .

[20]  L. Brasseur,et al.  Constancy of effort and variability of maximal expiratory flow rates. , 1979, Chest.

[21]  J. Ultman,et al.  Longitudinal mixing in pulmonary airways--normal subjects respiring at a constant flow. , 1978, Journal of applied physiology: respiratory, environmental and exercise physiology.

[22]  M. Horsmanheimo,et al.  Lung biology in health and disease , 1977 .

[23]  J. N. Evans,et al.  Uneven ventilation in smokers. , 1976, Respiration physiology.

[24]  A. C. Young,et al.  A theoretical discussion of diffusion and convection in the lung , 1976 .

[25]  R. Cherniack,et al.  Intraindividual variability in maximal expiratory flow-volume and closing volume in asymptomatic subjects. , 2015, The American review of respiratory disease.

[26]  J. Mead,et al.  Effect of lung inflation on bronchial length and diameter in excised lungs. , 1972, Journal of applied physiology.

[27]  J. Heyder,et al.  The breathing of half micron aerosols—III dispersion of particles in the respiratory tract , 1971 .

[28]  P. Macklem,et al.  Frequency dependence of compliance as a test for obstruction in the small airways. , 1969, The Journal of clinical investigation.

[29]  K. B. Bischoff,et al.  Notes on the diffusion-type model for longitudinal mixing in flow: Concerning papers by O. Levenspiel, W.K. Smith, E. Van der Laan and R. Aris , 1960 .

[30]  E. Palmes,et al.  Intrapulmonary mixing of gases studied with aerosols. , 1959, Journal of applied physiology.