论文信息 - A New Triterpene From Uncaria macrophylla and Its Antitumor Activity

A New Triterpene From Uncaria macrophylla and Its Antitumor Activity

On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D (1H-1H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC50 values of 78.2 µg/mL and 73.9 µg/mL.

[1] Xu-dong Xu,et al. A New Triterpene from the Plant of Uncaria Macrophylla , 2012, Molecules.

[2] K. Wurst,et al. X-Ray crystal structure analysis of oxindole alkaloids , 2003 .

[3] D. Kingston,et al. Bioactive indole alkaloids from the bark of Uncaria guianensis. , 1999, Planta medica.

[4] J. Ahn,et al. Uncarinic Acids: Phospholipase Cγ1 Inhibitors from Hooks of Uncaria rhynchophylla. , 1999 .

[5] Y. Takenaka,et al. Oxindole Alkaloids from Uncaria setiloba(Natural Medicine Note) , 1997 .

[6] H. Wagner,et al. Pharmacologically active procyanidines from the bark of Uncaria tomentosa. , 1997, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[7] V. De Feo,et al. Quinovic acid glycosides from Uncaria guianensis. , 1991, Phytochemistry.

[8] K. Likhitwitayawuid,et al. Triterpenoidal constituents of uncaria florida vidal , 1989 .

[9] C. Ridsdale. A revision of Mitragyna and Uncaria (Rubiaceae) , 1978 .

[10] D. Doddrell,et al. The stereochemical dependence of 13C chemical shifts in olean-12-enes and urs-12-enes as an aid to structural assignment , 1974 .