Using tDCS to Explore the Role of the Right Temporo-Parietal Junction in Theory of Mind and Cognitive Empathy

The right temporo-parietal junction (rTPJ) is thought to be closely related to theory of mind (ToM) and cognitive empathy. In the present study, we investigated whether these socio-cognitive abilities could be modulated with non-invasive transcranial direct current stimulation (tDCS) of the rTPJ. Participants received anodal (excitatory), cathodal (inhibitory), or sham stimulation before performing a social cognitive task which included inferring other’s intention (the ToM condition) and inferring other’s emotion (the cognitive empathy condition). Our results showed that the accuracy of both ToM and cognitive empathy decreased after receiving the cathodal stimulation, suggesting that altering the cortical excitability in the rTPJ could influence human’s socio-cognitive abilities. The results of this study emphasize the critical role of the rTPJ in ToM and cognitive empathy and demonstrate that these socio-cognitive abilities could be modulated by the tDCS.

[1]  R Saxe,et al.  People thinking about thinking people The role of the temporo-parietal junction in “theory of mind” , 2003, NeuroImage.

[2]  Geoffrey Bird,et al.  Enhancing Social Ability by Stimulating Right Temporoparietal Junction Tdcs of Right Tpj , 2022 .

[3]  Valer Jurcak,et al.  10/20, 10/10, and 10/5 systems revisited: Their validity as relative head-surface-based positioning systems , 2007, NeuroImage.

[4]  J. Perner,et al.  An evaluation of neurocognitive models of theory of mind , 2015, Front. Psychol..

[5]  Paul J. Eslinger,et al.  Neurological and Neuropsychological Bases of Empathy , 1998, European Neurology.

[6]  J. Aharon-Peretz,et al.  Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. , 2009, Brain : a journal of neurology.

[7]  Marcel Brass,et al.  Control of shared representations relies on key processes involved in mental state attribution , 2009, Human brain mapping.

[8]  F. D. Waal.  Putting the Altruism Back into Altruism: The Evolution of Empathy , 2008 .

[9]  J. Rothwell,et al.  Speech Facilitation by Left Inferior Frontal Cortex Stimulation , 2011, Current Biology.

[10]  Gottfried Schlaug,et al.  Anodal Transcranial Direct Current Stimulation of the Prefrontal Cortex Enhances Complex Verbal Associative Thought , 2009, Journal of Cognitive Neuroscience.

[11]  Joel H Kramer,et al.  Patterns of Cognitive and Emotional Empathy in Frontotemporal Lobar Degeneration , 2005, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.

[12]  J Aharon-Peretz,et al.  The neuroanatomical basis of understanding sarcasm and its relationship to social cognition. , 2005, Neuropsychology.

[13]  H. Möller,et al.  Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI , 2011, The Journal of Neuroscience.

[14]  R. Blair.  Responding to the emotions of others: Dissociating forms of empathy through the study of typical and psychiatric populations , 2005, Consciousness and Cognition.

[15]  G. Fink,et al.  Reorganization of cerebral networks after stroke: new insights from neuroimaging with connectivity approaches , 2011, Brain : a journal of neurology.

[16]  Uta Frith,et al.  Cognitive psychology - Interacting minds - A biological basis , 1999 .

[17]  E. Palazidou.  The neurobiology of depression. , 2012, British medical bulletin.

[18]  Sara Torriero,et al.  Prefrontal and Temporo-Parietal Involvement in Taking Others’ Perspective: TMS Evidence , 2008, Behavioural neurology.

[19]  Hang Ye,et al.  Modulation of Neural Activity in the Temporoparietal Junction with Transcranial Direct Current Stimulation Changes the Role of Beliefs in Moral Judgment , 2015, Front. Hum. Neurosci..

[20]  Brian E. Russ,et al.  TMS affects moral judgment, showing the role of DLPFC and TPJ in cognitive and emotional processing , 2014, Front. Neurosci..

[21]  C. Frith,et al.  Interacting minds--a biological basis. , 1999, Science.

[22]  Mark H. Davis.  Measuring individual differences in empathy: Evidence for a multidimensional approach. , 1983 .

[23]  F. D. de Waal.  Putting the altruism back into altruism: the evolution of empathy. , 2008, Annual review of psychology.

[24]  F. Overwalle.  Social cognition and the brain: a meta-analysis. , 2009 .

[25]  Geoffrey Bird,et al.  Functional lateralization of temporoparietal junction – imitation inhibition, visual perspective‐taking and theory of mind , 2015, The European journal of neuroscience.

[26]  G. Bird,et al.  Transcranial Current Stimulation of the Temporoparietal Junction Improves Lie Detection , 2015, Current Biology.

[27]  R. Saxe,et al.  The neural basis of the interaction between theory of mind and moral judgment , 2007, Proceedings of the National Academy of Sciences.

[28]  宁北芳,et al.  疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A , 2005 .

[29]  B. Berger,et al.  Characterization of Empathy Deficits following Prefrontal Brain Damage: The Role of the Right Ventromedial Prefrontal Cortex , 2003, Journal of Cognitive Neuroscience.

[30]  Henrik Walter,et al.  Functional relations of empathy and mentalizing: An fMRI study on the neural basis of cognitive empathy , 2011, NeuroImage.

[31]  S. Preston,et al.  Empathy: Its ultimate and proximate bases. , 2001, The Behavioral and brain sciences.

[32]  Rebecca Saxe,et al.  An fMRI Investigation of Spontaneous Mental State Inference for Moral Judgment , 2009, Journal of Cognitive Neuroscience.

[33]  R. Saxe,et al.  Making sense of another mind: The role of the right temporo-parietal junction , 2005, Neuropsychologia.

[34]  Mark H. Davis,et al.  A Multidimensional Approach to Individual Differences in Empathy , 1980 .

[35]  M. Nitsche,et al.  Increasing the role of belief information in moral judgments by stimulating the right temporoparietal junction , 2015, Neuropsychologia.

[36]  Michael Erb,et al.  Task-specific activity and connectivity within the mentalizing network during emotion and intention mentalizing , 2011, NeuroImage.

[37]  G. Schlaug,et al.  The Use of Non-invasive Brain Stimulation Techniques to Facilitate Recovery from Post-stroke Aphasia , 2011, Neuropsychology Review.

[38]  R. Saxe,et al.  Disruption of the right temporoparietal junction with transcranial magnetic stimulation reduces the role of beliefs in moral judgments , 2010, Proceedings of the National Academy of Sciences.

[39]  F. Van Overwalle.  Social cognition and the brain: A meta‐analysis , 2009, Human brain mapping.

[40]  S. Jaberzadeh,et al.  Non-Invasive Brain Stimulation for Enhancement of Corticospinal Excitability and Motor Performance , 2013, Basic and clinical neuroscience.

[41]  K. Zilles,et al.  Mind Reading: Neural Mechanisms of Theory of Mind and Self-Perspective , 2001, NeuroImage.

[42]  Rebecca Elliott,et al.  Neuronal correlates of theory of mind and empathy: A functional magnetic resonance imaging study in a nonverbal task , 2006, NeuroImage.

[43]  Henrik Walter,et al.  Social Cognitive Neuroscience of Empathy: Concepts, Circuits, and Genes , 2012 .

[44]  Robert Lindenberg,et al.  Optimizing recovery potential through simultaneous occupational therapy and non-invasive brain-stimulation using tDCS. , 2011, Restorative neurology and neuroscience.