The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

[1]  A. Egashira,et al.  Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 , 2011, Cell.

[2]  Scott H. Kaufmann,et al.  Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells , 2011, Proceedings of the National Academy of Sciences.

[3]  V. Schreiber,et al.  Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression , 2011, Proceedings of the National Academy of Sciences.

[4]  M. Gorospe,et al.  miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. , 2011, Molecular cell.

[5]  B. Reina-San-Martin,et al.  PARP-3 and APLF function together to accelerate nonhomologous end-joining. , 2011, Molecular cell.

[6]  Cristina Al-Khalili Szigyarto,et al.  Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate , 2010, Nucleic acids research.

[7]  T. Helleday,et al.  Pathways of mammalian replication fork restart , 2010, Nature Reviews Molecular Cell Biology.

[8]  T. Helleday,et al.  Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage. , 2010, Journal of molecular biology.

[9]  T. Helleday,et al.  Targeting homologous recombination repair defects in cancer. , 2010, Trends in pharmacological sciences.

[10]  Ricky A. Sharma,et al.  Molecular and Cellular Pathobiology Cancer Research Poly ( ADP-Ribose ) Polymerase Is Hyperactivated in Homologous Recombination – Defective Cells , 2010 .

[11]  A. Oza,et al.  Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer. , 2010 .

[12]  D. Adams,et al.  53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers , 2010, Nature Structural &Molecular Biology.

[13]  Jeremy M. Stark,et al.  53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks , 2010, Cell.

[14]  Y. Drew,et al.  Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors , 2010, Clinical Cancer Research.

[15]  T. Helleday,et al.  Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair , 2010, Molecular cell.

[16]  R. Schwab,et al.  ATR activation and replication fork restart are defective in FANCM‐deficient cells , 2010, The EMBO journal.

[17]  T. Helleday,et al.  PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA* , 2010, The Journal of Biological Chemistry.

[18]  A. Ashworth,et al.  Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. , 2009, The New England journal of medicine.

[19]  T. Helleday,et al.  PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination , 2009, The EMBO journal.

[20]  D. Sgroi,et al.  Utility of DNA Repair Protein Foci for the Detection of Putative BRCA1 Pathway Defects in Breast Cancer Biopsies , 2009, Molecular Cancer Research.

[21]  J. Weigelt,et al.  Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. , 2009, Journal of medicinal chemistry.

[22]  P. Borst,et al.  High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs , 2008, Proceedings of the National Academy of Sciences.

[23]  N. Curtin,et al.  PARP inhibitor development for systemic cancer targeting. , 2007, Anti-cancer agents in medicinal chemistry.

[24]  J. Peterse,et al.  Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer , 2007, Proceedings of the National Academy of Sciences.

[25]  Ian D Hickson,et al.  Role for BLM in replication-fork restart and suppression of origin firing after replicative stress , 2007, Nature Structural &Molecular Biology.

[26]  K. Caldecott,et al.  Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase , 2007, Molecular and Cellular Biology.

[27]  V. Schreiber,et al.  Poly(ADP-ribose): novel functions for an old molecule , 2006, Nature Reviews Molecular Cell Biology.

[28]  V. Schreiber,et al.  Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells , 2006, The EMBO journal.

[29]  T. Helleday,et al.  Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks , 2005, Nucleic acids research.

[30]  Alan Ashworth,et al.  Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy , 2005, Nature.

[31]  Thomas Helleday,et al.  Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase , 2005, Nature.

[32]  Zhao-Qi Wang,et al.  Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks , 2004, Oncogene.

[33]  R. Tebbs,et al.  Rescue of Xrcc1 knockout mouse embryo lethality by transgene-complementation. , 2003, DNA repair.

[34]  T. Helleday Pathways for mitotic homologous recombination in mammalian cells. , 2003, Mutation research.

[35]  Mitsuko Masutani,et al.  A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. , 2003, Nucleic acids research.

[36]  K. Caldecott XRCC1 and DNA strand break repair. , 2003, DNA repair.

[37]  T. Helleday,et al.  Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. , 2003, Nucleic acids research.

[38]  P. Chambon,et al.  Functional interaction between PARP‐1 and PARP‐2 in chromosome stability and embryonic development in mouse , 2003, The EMBO journal.

[39]  J. Vonesch,et al.  PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression , 2003, Journal of Cell Science.

[40]  G. Dianov,et al.  Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing. , 2003, Acta biochimica Polonica.

[41]  T. Helleday,et al.  Different Roles for Nonhomologous End Joining and Homologous Recombination following Replication Arrest in Mammalian Cells , 2002, Molecular and Cellular Biology.

[42]  P. Dollé,et al.  Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1* , 2002, The Journal of Biological Chemistry.

[43]  Ashok R Venkitaraman,et al.  Cancer Susceptibility and the Functions of BRCA1 and BRCA2 , 2002, Cell.

[44]  D. Averbeck,et al.  Characterisation of homologous recombination induced by replication inhibition in mammalian cells , 2020 .

[45]  T. Helleday,et al.  DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. , 2001, Journal of molecular biology.

[46]  V. Schreiber,et al.  Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1. , 2000, Biochemistry.

[47]  Y. Pommier,et al.  Conversion of Topoisomerase I Cleavage Complexes on the Leading Strand of Ribosomal DNA into 5′-Phosphorylated DNA Double-Strand Breaks by Replication Runoff , 2000, Molecular and Cellular Biology.

[48]  G. Poirier,et al.  Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. , 1999, The Biochemical journal.

[49]  S. Lees-Miller,et al.  Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions. , 1999, Biochimica et biophysica acta.

[50]  V. Schreiber,et al.  Involvement of poly(ADP-ribose) polymerase in base excision repair. , 1999, Biochimie.

[51]  J. Ménissier-de murcia,et al.  DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines. , 1998, Nucleic acids research.

[52]  J. Vonesch,et al.  Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication. , 1998, Nucleic acids research.

[53]  L. Hartwell,et al.  Integrating genetic approaches into the discovery of anticancer drugs. , 1997, Science.

[54]  E. Wagner,et al.  PARP is important for genomic stability but dispensable in apoptosis. , 1997, Genes & development.

[55]  P. Chambon,et al.  Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[56]  C. Simbulan-Rosenthal,et al.  The expression of poly(ADP-ribose) polymerase during differentiation-linked DNA replication reveals that it is a component of the multiprotein DNA replication complex. , 1996, Biochemistry.

[57]  Richard J Smeyne,et al.  The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[58]  Julian Peto,et al.  Identification of the breast cancer susceptibility gene BRCA2 , 1996, Nature.

[59]  D. Bentley,et al.  Identification of the breast cancer susceptibility gene BRCA2 , 1995, Nature.

[60]  T. Lindahl,et al.  Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. , 1995, Trends in biochemical sciences.

[61]  N. Curtin,et al.  Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP). , 1995, Anti-cancer drug design.

[62]  Steven E. Bayer,et al.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. , 1994, Science.

[63]  K. Rajewsky,et al.  Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. , 1994, Science.

[64]  T. Lindahl Instability and decay of the primary structure of DNA , 1993, Nature.

[65]  C. Simbulan Poly(ADP-ribose) polymerase stimulates DNA polymerase α by physical association , 1993 .

[66]  Y. Shizuta,et al.  Poly(ADP-ribose) polymerase stimulates DNA polymerase alpha by physical association. , 1993, The Journal of biological chemistry.

[67]  Masahiko S. Satoh,et al.  Role of poly(ADP-ribose) formation in DNA repair , 1992, Nature.

[68]  G. Poirier,et al.  DNA replication and poly(ADP-ribosyl)ation of chromatin. , 1989, Cytobios.

[69]  W. Morgan,et al.  3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet light. , 1982, Mutation research.

[70]  T. Sugimura,et al.  Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges. , 1980, Biochemical and biophysical research communications.

[71]  B. Durkacz,et al.  (ADP-ribose)n participates in DNA excision repair , 1980, Nature.

[72]  T. Butt,et al.  Nuclear protein modification and chromatin substructure. 3. Relationship between poly(adenosine diphosphate) ribosylation and different functional forms of chromatin. , 1979, Biochemistry.

[73]  S. Shall,et al.  Poly(adenosine diphosphate ribose) polymerase in Physarum polycephalum. , 1971, The Biochemical journal.

[74]  A. Lehmann,et al.  The relationship between cell growth, macromolecular synthesis and poly ADP-ribose polymerase in lymphoid cells. , 1974, Experimental cell research.

[75]  H. Pitot,et al.  The association in vitro of polyribosomes with ribonuclease-treated derivatives of hepatic rough endoplasmic reticulum. Characteristics of the membrane binding sites and factors influencing association. , 1971, The Biochemical journal.

[76]  S. Shall,et al.  Poly(adenosine diphosphate ribose) polymerase in Physarum polycephalum nuclei. , 1971, The Biochemical journal.