The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
暂无分享,去创建一个
[1] A. Egashira,et al. Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 , 2011, Cell.
[2] Scott H. Kaufmann,et al. Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells , 2011, Proceedings of the National Academy of Sciences.
[3] V. Schreiber,et al. Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression , 2011, Proceedings of the National Academy of Sciences.
[4] M. Gorospe,et al. miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. , 2011, Molecular cell.
[5] B. Reina-San-Martin,et al. PARP-3 and APLF function together to accelerate nonhomologous end-joining. , 2011, Molecular cell.
[6] Cristina Al-Khalili Szigyarto,et al. Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate , 2010, Nucleic acids research.
[7] T. Helleday,et al. Pathways of mammalian replication fork restart , 2010, Nature Reviews Molecular Cell Biology.
[8] T. Helleday,et al. Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage. , 2010, Journal of molecular biology.
[9] T. Helleday,et al. Targeting homologous recombination repair defects in cancer. , 2010, Trends in pharmacological sciences.
[10] Ricky A. Sharma,et al. Molecular and Cellular Pathobiology Cancer Research Poly ( ADP-Ribose ) Polymerase Is Hyperactivated in Homologous Recombination – Defective Cells , 2010 .
[11] A. Oza,et al. Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer. , 2010 .
[12] D. Adams,et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers , 2010, Nature Structural &Molecular Biology.
[13] Jeremy M. Stark,et al. 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks , 2010, Cell.
[14] Y. Drew,et al. Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors , 2010, Clinical Cancer Research.
[15] T. Helleday,et al. Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair , 2010, Molecular cell.
[16] R. Schwab,et al. ATR activation and replication fork restart are defective in FANCM‐deficient cells , 2010, The EMBO journal.
[17] T. Helleday,et al. PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA* , 2010, The Journal of Biological Chemistry.
[18] A. Ashworth,et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. , 2009, The New England journal of medicine.
[19] T. Helleday,et al. PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination , 2009, The EMBO journal.
[20] D. Sgroi,et al. Utility of DNA Repair Protein Foci for the Detection of Putative BRCA1 Pathway Defects in Breast Cancer Biopsies , 2009, Molecular Cancer Research.
[21] J. Weigelt,et al. Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. , 2009, Journal of medicinal chemistry.
[22] P. Borst,et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs , 2008, Proceedings of the National Academy of Sciences.
[23] N. Curtin,et al. PARP inhibitor development for systemic cancer targeting. , 2007, Anti-cancer agents in medicinal chemistry.
[24] J. Peterse,et al. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer , 2007, Proceedings of the National Academy of Sciences.
[25] Ian D Hickson,et al. Role for BLM in replication-fork restart and suppression of origin firing after replicative stress , 2007, Nature Structural &Molecular Biology.
[26] K. Caldecott,et al. Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase , 2007, Molecular and Cellular Biology.
[27] V. Schreiber,et al. Poly(ADP-ribose): novel functions for an old molecule , 2006, Nature Reviews Molecular Cell Biology.
[28] V. Schreiber,et al. Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells , 2006, The EMBO journal.
[29] T. Helleday,et al. Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks , 2005, Nucleic acids research.
[30] Alan Ashworth,et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy , 2005, Nature.
[31] Thomas Helleday,et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase , 2005, Nature.
[32] Zhao-Qi Wang,et al. Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks , 2004, Oncogene.
[33] R. Tebbs,et al. Rescue of Xrcc1 knockout mouse embryo lethality by transgene-complementation. , 2003, DNA repair.
[34] T. Helleday. Pathways for mitotic homologous recombination in mammalian cells. , 2003, Mutation research.
[35] Mitsuko Masutani,et al. A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. , 2003, Nucleic acids research.
[36] K. Caldecott. XRCC1 and DNA strand break repair. , 2003, DNA repair.
[37] T. Helleday,et al. Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. , 2003, Nucleic acids research.
[38] P. Chambon,et al. Functional interaction between PARP‐1 and PARP‐2 in chromosome stability and embryonic development in mouse , 2003, The EMBO journal.
[39] J. Vonesch,et al. PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression , 2003, Journal of Cell Science.
[40] G. Dianov,et al. Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing. , 2003, Acta biochimica Polonica.
[41] T. Helleday,et al. Different Roles for Nonhomologous End Joining and Homologous Recombination following Replication Arrest in Mammalian Cells , 2002, Molecular and Cellular Biology.
[42] P. Dollé,et al. Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1* , 2002, The Journal of Biological Chemistry.
[43] Ashok R Venkitaraman,et al. Cancer Susceptibility and the Functions of BRCA1 and BRCA2 , 2002, Cell.
[44] D. Averbeck,et al. Characterisation of homologous recombination induced by replication inhibition in mammalian cells , 2020 .
[45] T. Helleday,et al. DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. , 2001, Journal of molecular biology.
[46] V. Schreiber,et al. Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1. , 2000, Biochemistry.
[47] Y. Pommier,et al. Conversion of Topoisomerase I Cleavage Complexes on the Leading Strand of Ribosomal DNA into 5′-Phosphorylated DNA Double-Strand Breaks by Replication Runoff , 2000, Molecular and Cellular Biology.
[48] G. Poirier,et al. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. , 1999, The Biochemical journal.
[49] S. Lees-Miller,et al. Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions. , 1999, Biochimica et biophysica acta.
[50] V. Schreiber,et al. Involvement of poly(ADP-ribose) polymerase in base excision repair. , 1999, Biochimie.
[51] J. Ménissier-de murcia,et al. DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines. , 1998, Nucleic acids research.
[52] J. Vonesch,et al. Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication. , 1998, Nucleic acids research.
[53] L. Hartwell,et al. Integrating genetic approaches into the discovery of anticancer drugs. , 1997, Science.
[54] E. Wagner,et al. PARP is important for genomic stability but dispensable in apoptosis. , 1997, Genes & development.
[55] P. Chambon,et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[56] C. Simbulan-Rosenthal,et al. The expression of poly(ADP-ribose) polymerase during differentiation-linked DNA replication reveals that it is a component of the multiprotein DNA replication complex. , 1996, Biochemistry.
[57] Richard J Smeyne,et al. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[58] Julian Peto,et al. Identification of the breast cancer susceptibility gene BRCA2 , 1996, Nature.
[59] D. Bentley,et al. Identification of the breast cancer susceptibility gene BRCA2 , 1995, Nature.
[60] T. Lindahl,et al. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. , 1995, Trends in biochemical sciences.
[61] N. Curtin,et al. Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP). , 1995, Anti-cancer drug design.
[62] Steven E. Bayer,et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. , 1994, Science.
[63] K. Rajewsky,et al. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. , 1994, Science.
[64] T. Lindahl. Instability and decay of the primary structure of DNA , 1993, Nature.
[65] C. Simbulan. Poly(ADP-ribose) polymerase stimulates DNA polymerase α by physical association , 1993 .
[66] Y. Shizuta,et al. Poly(ADP-ribose) polymerase stimulates DNA polymerase alpha by physical association. , 1993, The Journal of biological chemistry.
[67] Masahiko S. Satoh,et al. Role of poly(ADP-ribose) formation in DNA repair , 1992, Nature.
[68] G. Poirier,et al. DNA replication and poly(ADP-ribosyl)ation of chromatin. , 1989, Cytobios.
[69] W. Morgan,et al. 3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet light. , 1982, Mutation research.
[70] T. Sugimura,et al. Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges. , 1980, Biochemical and biophysical research communications.
[71] B. Durkacz,et al. (ADP-ribose)n participates in DNA excision repair , 1980, Nature.
[72] T. Butt,et al. Nuclear protein modification and chromatin substructure. 3. Relationship between poly(adenosine diphosphate) ribosylation and different functional forms of chromatin. , 1979, Biochemistry.
[73] S. Shall,et al. Poly(adenosine diphosphate ribose) polymerase in Physarum polycephalum. , 1971, The Biochemical journal.
[74] A. Lehmann,et al. The relationship between cell growth, macromolecular synthesis and poly ADP-ribose polymerase in lymphoid cells. , 1974, Experimental cell research.
[75] H. Pitot,et al. The association in vitro of polyribosomes with ribonuclease-treated derivatives of hepatic rough endoplasmic reticulum. Characteristics of the membrane binding sites and factors influencing association. , 1971, The Biochemical journal.
[76] S. Shall,et al. Poly(adenosine diphosphate ribose) polymerase in Physarum polycephalum nuclei. , 1971, The Biochemical journal.