Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis.

OBJECTIVE To reveal the relationship between anti-Golgi antibody (AGA) and clinical diseases through retrospective analysis. METHODS The clinical data of 584 cases testing positive for AGA in the past 11 years were collected and retrospectively analyzed. RESULTS AGA pattern accounted for .2% of positive ANA results. In total, 35.0% of diagnosed patients had autoimmune diseases (AID), mainly rheumatoid arthritis (RA). High-titer AGA (≧1:1000) was common in AID. In nondiagnosed patients with clinical symptoms, joint pain/muscle pain was the most common. CONCLUSIONS Positive AGA with high titer was closely related to RA. Joint pain/muscle pain was the most common symptom in patients who tested AGA positive. Therefore, AGA may be a key indicator of RA in the Chinese population.

[1]  S. Platzgummer,et al.  A new diagnostic algorithm for pattern-oriented autoantibody testing according to the ICAP nomenclature: A pilot study. , 2020, Autoimmunity reviews.

[2]  Aiping Zeng,et al.  Anti-golgi antibodies: Prevalence and disease association in Chinese population. , 2019, Clinica chimica acta; international journal of clinical chemistry.

[3]  S. Čučnik,et al.  Evaluating the utility of autoantibodies for disease activity and relapse in giant cell arteritis. , 2018, Journal of Biological Regulators and Homeostatic Agents.

[4]  A. Avan,et al.  Current Status and Prospective Regarding the Therapeutic Potential of Natural Autoantibodies in Cancer Therapy , 2017, Journal of cellular physiology.

[5]  Jin-liang Kong,et al.  Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer: A systematic review and meta-analysis , 2017, PloS one.

[6]  N. Bizzaro,et al.  Challenges in the Standardization of Autoantibody Testing: a Comprehensive Review , 2017, Clinical Reviews in Allergy & Immunology.

[7]  Ruo-Pan Huang,et al.  Identification and characterization of monoclonal antibodies against GP73 for use as a potential biomarker in liver cancer screening and diagnosis , 2016, Journal of immunoassay & immunochemistry.

[8]  H. Brenner,et al.  A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection , 2016, Oncotarget.

[9]  B. Milenković,et al.  Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia. , 2016, Internal medicine.

[10]  A. Şener,et al.  Evaluation of antinuclear antibodies by indirect immunofluorescence and line immunoassay methods′: four years′ data from Turkey , 2014, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[11]  A. Aggarwal.  Role of autoantibody testing. , 2014, Best practice & research. Clinical rheumatology.

[12]  Pierre Bongrand,et al.  Original Approach for Automated Quantification of Antinuclear Autoantibodies by Indirect Immunofluorescence , 2013, Clinical & developmental immunology.

[13]  Xavier Bossuyt,et al.  Prevalence and clinical significance of rare antinuclear antibody patterns. , 2013, Autoimmunity reviews.

[14]  P. Pokreisz,et al.  Betaine homocysteine methyl transferase 1, a novel auto-antigen associated with anti-Golgi immune reactivity. , 2012, Clinica chimica acta; international journal of clinical chemistry.

[15]  P. Vermeersch,et al.  Anti-Golgi autoantibodies are not clinically associated with systemic autoimmune diseases , 2010, Annals of the rheumatic diseases.

[16]  W. Chung,et al.  Clinical Association of Anti‐Golgi Autoantibodies and their Autoantigens , 2004, Scandinavian journal of immunology.

[17]  E. Chan,et al.  Giantin is the major Golgi autoantigen in human anti-Golgi complex sera , 2003, Arthritis research & therapy.

[18]  E. Chan,et al.  Fragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis , 2002, Arthritis research.

[19]  J. Fujita,et al.  Clinical features of several connective tissue diseases with anti-Golgi antibody , 2001, Annals of the rheumatic diseases.

[20]  T. Thomson,et al.  Anti-golgi complex autoantibodies in a patient with Sjögren syndrome and lymphoma. , 1982, Clinical and experimental immunology.