CORRIGENDUM: Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

Gold nanoparticles (GNPs) are being proposed as contrast agents to enhance X-ray imaging and radiotherapy, seeking to take advantage of the increased X-ray absorption of gold compared to soft tissue. However, there is a great discrepancy between physically predicted increases in X-ray energy deposition and experimentally observed increases in cell killing. In this work, we present the first calculations which take into account the structure of energy deposition in the nanoscale vicinity of GNPs and relate this to biological outcomes, and show for the first time good agreement with experimentally observed cell killing by the combination of X-rays and GNPs. These results are not only relevant to radiotherapy, but also have implications for applications of heavy atom nanoparticles in biological settings or where human exposure is possible because the localised energy deposition high-lighted by these results may cause complex DNA damage, leading to mutation and carcinogenesis.

[1]  M. Scholz,et al.  Calculation of Heavy Ion Inactivation Probabilities Based on Track Structure, X Ray Sensitivity and Target Size , 1994 .

[2]  J. Klaveness,et al.  Molecular and Crystal Structure of Iodixanol, a New X-Ray Contrast Agent , 1995 .

[3]  Everett E. Carpenter,et al.  Gold-coated iron (Fe@Au) nanoparticles: Synthesis, characterization, and magnetic field-induced self-assembly , 2001 .

[4]  J. Robar,et al.  Tumour dose enhancement using modified megavoltage photon beams and contrast media. , 2002, Physics in medicine and biology.

[5]  Jack Valentin,et al.  Relative biological effectiveness (RBE), quality factor (Q), and radiation weighting factor (wR) , 2003 .

[6]  S. Webb.  The physical basis of IMRT and inverse planning. , 2003, The British journal of radiology.

[7]  Dorothy Farrell,et al.  Gold-coated iron nanoparticles for biomedical applications , 2003 .

[8]  Viswanadham Garimella,et al.  Homogeneous detection of unamplified genomic DNA sequences based on colorimetric scatter of gold nanoparticle probes , 2004, Nature Biotechnology.

[9]  Charles T. Campbell,et al.  The Active Site in Nanoparticle Gold Catalysis , 2004, Science.

[10]  Sang Hyun Cho,et al.  Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study , 2005, Physics in medicine and biology.

[11]  Juewen Liu,et al.  Preparation of aptamer-linked gold nanoparticle purple aggregates for colorimetric sensing of analytes , 2006, Nature Protocols.

[12]  J. Robar,et al.  Generation and modelling of megavoltage photon beams for contrast-enhanced radiation therapy , 2006, Physics in medicine and biology.

[13]  J F Hainfeld,et al.  Gold nanoparticles: a new X-ray contrast agent. , 2006, The British journal of radiology.

[14]  Arezou A Ghazani,et al.  Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. , 2006, Nano letters.

[15]  Jacques Balosso,et al.  Enhanced Survival and Cure of F98 Glioma–Bearing Rats following Intracerebral Delivery of Carboplatin in Combination with Photon Irradiation , 2007, Clinical Cancer Research.

[16]  Ting Guo,et al.  Nanoscale energy deposition by X-ray absorbing nanostructures. , 2007, The journal of physical chemistry. B.

[17]  J. Karp,et al.  Nanocarriers as an Emerging Platform for Cancer Therapy , 2022 .

[18]  Kwon-Ha Yoon,et al.  Colloidal Gold Nanoparticles as a Blood-Pool Contrast Agent for X-ray Computed Tomography in Mice , 2007, Investigative radiology.

[19]  Michael Scholz,et al.  Cluster Effects within the Local Effect Model , 2007, Radiation research.

[20]  S. Chauvie,et al.  Geant4 Physics Processes for Microdosimetry Simulation: Design Foundation and Implementation of the First Set of Models , 2007, IEEE Transactions on Nuclear Science.

[21]  Sung Yong Park,et al.  DNA-programmable nanoparticle crystallization , 2008, Nature.

[22]  Stephen J McMahon,et al.  Radiotherapy in the presence of contrast agents: a general figure of merit and its application to gold nanoparticles , 2008, Physics in medicine and biology.

[23]  J. Hainfeld,et al.  Radiotherapy enhancement with gold nanoparticles , 2008, The Journal of pharmacy and pharmacology.

[24]  Brian F. G. Johnson,et al.  Selective oxidation with dioxygen by gold nanoparticle catalysts derived from 55-atom clusters , 2008, Nature.

[25]  Emilie Brun,et al.  Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solution. , 2009, Colloids and surfaces. B, Biointerfaces.

[26]  G Schettino,et al.  Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy , 2010, Nanotechnology.

[27]  Sang Hyun Cho,et al.  Estimation of microscopic dose enhancement factor around gold nanoparticles by Monte Carlo calculations. , 2010, Medical physics.

[28]  Salomeh Jelveh,et al.  Gold Nanoparticles as Radiation Sensitizers in Cancer Therapy , 2010, Radiation research.

[29]  Alan R Hounsell,et al.  Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. , 2011, International journal of radiation oncology, biology, physics.