Multimodal gadolinium-enriched DNA-gold nanoparticle conjugates for cellular imaging.

During the past two decades, magnetic resonance imaging (MRI) has become a powerful technique in clinical diagnosis and biological molecular imaging.[1–4] A signficant advantage of MRI is the ability to acquire tomographic information of whole animals with high spatial resolution and soft tissue contrast. In addition, images are acquired without the use of ionizing radiation (e.g., X-ray and CT) or radiotracers (e.g., PET and SPECT) permitting long term longitudinal studies. Since spatial resolution increases with magnetic field strength, the ability to track small cell populations has been realized.

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