A diffi cult case of Crohn's disease?

BACKGROUND Chronic granulomatous disease (CGD) is a rare genetically heterogenous primary immunodefi ciency disorder. About 20% of patients are affected by granulomatous colitis mimicking Crohn’s disease. Although the infl ammatory process in the gut in CGD may be different from that in Crohn’s, the clinical, endoscopic, radiological and histological features may be indistinguishable. Management of this granulomatous colitis can be a challenge in view of the high risk of sepsis on introducing immunosuppressant drugs.