The Sinus Node in Sudden Infant Death Syndrome

The sinus node (SN) was examined histologically in 30 infants diagnosed with sudded infant death syndrome (SIDS) and in 18 age-matched controls who died of known causes. Location, size and organization of the SN did not differ significantly in the two groups. Petechiae involved the SN region in 20% of SIDS and 17% of control infants and probably do not represent a primary event. In three SIDS infants (10%), intimal lesions reduced the lumen of the intranodal SN artery by 63–83% in cross-sectional area. These resembled the intimal thickenings frequently observed in main epicardial coronary arteries of infants. Whether the vascular alterations in these three cases had adverse effects upon SN function is unknown.

[1]  M. Valdés-Dapena,et al.  Sudden infant death syndrome: a review of the medical literature 1974-1979. , 1980, Pediatrics.

[2]  L. Reid,et al.  Increased Muscularity of the Pulmonary Circulation in Victims of Sudden Infant Death Syndrome , 1979, Pediatrics.

[3]  G. Vawter,et al.  Increased muscularity of the pylmonary circulation in victims of sudden infant death syndrome. , 1979, Pediatrics.

[4]  F. I. Bonke.  The Sinus Node , 1978, Springer Netherlands.

[5]  J. Emery.  The neonatal electrocardiogram and unexpected death in infancy. , 1977, British medical journal.

[6]  T. K. Marshall,et al.  De subitaneis mortibus. XVII. Multifocal stenoses due to fibromuscular dysplasia of the sinus node artery. , 1976, Circulation.

[7]  P. Schwartz.  Cardiac sympathetic innervation and the sudden infant death syndrome. A possible pathogenetic link. , 1976, The American journal of medicine.

[8]  H. Rosenberg,et al.  Histopathology of the Conduction System in the Sudden Infant Death Syndrome , 1976, Circulation.

[9]  L. Salk,et al.  Sudden infant death. Normal cardiac habituation and poor autonomic control. , 1974, The New England journal of medicine.

[10]  R. Anderson,et al.  Sudden Death in Infancy: A Study of Cardiac Specialized Tissue , 1974, British medical journal.

[11]  R. Truex,et al.  The myocardial conduction system in sudden death in infancy. , 1973, The New England journal of medicine.

[12]  J. Ferris.  Hypoxic Changes in Conducting Tissue of the Heart in Sudden Death in Infancy Syndrome , 1973, British medical journal.

[13]  J. Ferris.  The heart in sudden infant death. , 1972, Journal - Forensic Science Society.

[14]  H. Russell.  A modification of Movat's pentachrome stain. , 1972, Archives of pathology.

[15]  J. Titus,et al.  The vasculature of the human sinus node. , 1972, Mayo Clinic proceedings.

[16]  T. N. James,et al.  Sudden death in babies: new observations in the heart. , 1968, The American journal of cardiology.

[17]  T. N. James,et al.  Distribution of cholinesterase within the sinus node and AV node of the human heart , 1966, The Anatomical record.

[18]  M. Karnovsky,et al.  A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES , 1964, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[19]  T. N. James,et al.  Myocardial Infarction and Atrial Arrhythmias , 1961, Circulation.

[20]  T. N. James,et al.  The response of sinus node function to ligation of the sinus node artery. , 1960, Henry Ford Hospital medical bulletin.

[21]  J. Robertson.  STRESS ZONES IN FOETAL ARTERIES , 1960, Journal of clinical pathology.