Waitlist and posttransplant outcomes of critically ill infants awaiting heart transplantation managed without ventricular assist device support

Infants listed for heart transplant are at high risk for waitlist mortality. While waitlist mortality for children has decreased in the current era of increased ventricular assist device use, outcomes for small infants supported by ventricular assist device remain suboptimal. We evaluated morbidity and survival in critically ill infants listed for heart transplant and managed without ventricular assist device support.

[1]  J. Jacobs,et al.  Fifth Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report. , 2021, The Annals of thoracic surgery.

[2]  P. Eghtesady,et al.  Berlin Heart EXCOR and ACTION post-approval surveillance study report. , 2021, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[3]  R. Spicer,et al.  Survival After Heart Transplant Listing for Infants on Mechanical Circulatory Support , 2020, Journal of the American Heart Association.

[4]  J. Jacobs,et al.  Fourth Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report. , 2020, The Annals of thoracic surgery.

[5]  L. Sleeper,et al.  The impact of pre-implant illness severity on the outcomes of pediatric patients undergoing durable ventricular assist device. , 2020, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[6]  C. VanderPluym,et al.  Utilization and Outcomes of Children Treated with Direct Thrombin Inhibitors on Paracorporeal Ventricular Assist Device Support. , 2019, ASAIO journal.

[7]  B. Meiser,et al.  The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric heart transplantation report - 2019; Focus theme: Donor and recipient size match. , 2019, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[8]  A. Amodeo,et al.  Improvement of survival in low-weight children on the Berlin Heart EXCOR ventricular assist device support†. , 2019, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[9]  B. Meiser,et al.  The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-first pediatric heart transplantation report-2018; Focus theme: Multiorgan Transplantation. , 2018, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[10]  J. Tweddell,et al.  Listing Low-Weight or Ill Infants for Heart Transplantation: Is It Prudent? , 2018, The Annals of thoracic surgery.

[11]  C. Canter,et al.  Pediatric heart transplantation across a positive crossmatch: First year results from the CTOTC‐04 multi‐institutional study , 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[12]  A. Oron,et al.  Comparison of Transplant Waitlist Outcomes for Pediatric Candidates Supported by Ventricular Assist Devices Versus Medical Therapy , 2018, Pediatric Critical Care Medicine.

[13]  G. Garcia-Guerra,et al.  Neurocognitive outcomes after heart transplantation in early childhood. , 2017, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[14]  P. Eghtesady,et al.  Infectious complications of ventricular assist device use in children in the United States: Data from the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs). , 2016, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[15]  W. Morrow,et al.  Improved Survival While Waiting and Risk Factors for Death in Pediatric Patients Listed for Cardiac Transplantation , 2016, Pediatric Cardiology.

[16]  J. Jefferies,et al.  Pediatric heart transplant waiting list mortality in the era of ventricular assist devices. , 2014, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[17]  S. Gidding,et al.  Low body mass index is associated with increased waitlist mortality among children listed for heart transplant. , 2014, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[18]  D. Morales,et al.  Delineating survival outcomes in children <10 kg bridged to transplant or recovery with the Berlin Heart EXCOR Ventricular Assist Device. , 2015, JACC. Heart failure.

[19]  C. Pizarro,et al.  Ventricular assist devices as a bridge-to-transplant improve early post-transplant outcomes in children. , 2014, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[20]  J. Friedland-Little,et al.  Abnormal nutrition affects waitlist mortality in infants awaiting heart transplant. , 2014, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[21]  E. Blackstone,et al.  Berlin Heart EXCOR Pediatric Ventricular Assist Device for Bridge to Heart Transplantation in US Children , 2013, Circulation.

[22]  K. Gauvreau,et al.  Trends in Wait‐List Mortality in Children Listed for Heart Transplantation in the United States: Era Effect Across Racial/Ethnic Groups , 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[23]  S. Webber,et al.  Heart Transplantation in the United States, 1999–2008 , 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[24]  R. Thiagarajan,et al.  Incidence and risk factors for mortality in infants awaiting heart transplantation in the USA. , 2009, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[25]  G. Schwartz,et al.  Measurement and estimation of GFR in children and adolescents. , 2009, Clinical journal of the American Society of Nephrology : CJASN.

[26]  R. Thiagarajan,et al.  Waiting List Mortality Among Children Listed for Heart Transplantation in the United States , 2009, Circulation.

[27]  S. Ashwal,et al.  Neuropsychological outcome of infant heart transplant recipients. , 2004, The Journal of pediatrics.

[28]  L. Bailey,et al.  A longitudinal perspective on neurodevelopmental outcome after infant cardiac transplantation. , 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[29]  M. Boucek,et al.  Developmental outcome of patients with hypoplastic left heart syndrome treated with heart transplantation. , 2003, The Journal of pediatrics.

[30]  J. Waterlow Classification and definition of protein-calorie malnutrition. , 1972, British medical journal.