Bubble-based acoustic radiation force using chirp insonation to reduce standing wave effects.

Bubble-based acoustic radiation force can measure local viscoelastic properties of tissue. High intensity acoustic waves applied to laser-generated bubbles induce displacements inversely proportional to local Young's modulus. In certain instances, long pulse durations are desirable but are susceptible to standing wave artifacts, which corrupt displacement measurements. Chirp pulse acoustic radiation force was investigated as a method to reduce standing wave artifacts. Chirp pulses with linear frequency sweep magnitudes of 100, 200 and 300 kHz centered around 1.5 MHz were applied to glass beads within gelatin phantoms and laser-generated bubbles within porcine lenses. The ultrasound transducer was translated axially to vary standing wave conditions, while comparing displacements using chirp pulses and 1.5 MHz tone burst pulses of the same duration and peak rarefactional pressure. Results demonstrated significant reduction in standing wave effects using chirp pulses, with displacement proportional to acoustic intensity and bubble size.

[1]  Louis Vessot King,et al.  On the Acoustic Radiation Pressure on Spheres , 1934 .

[2]  Anthony I. Eller,et al.  Force on a Bubble in a Standing Acoustic Wave , 1968 .

[3]  James F. Greenleaf,et al.  Chirp imaging vibro-acoustography for removing the ultrasound standing wave artifact , 2005, IEEE Transactions on Medical Imaging.

[4]  F JANSSON,et al.  DETERMINATION OF THE VELOCITY OF ULTRASOUND IN THE HUMAN LENS AND VITREOUS , 1962, Acta ophthalmologica.

[5]  M. O’Donnell,et al.  Spatially mapping the elastic properties of the lens using bubble-based acoustic radiation force , 2005, IEEE Ultrasonics Symposium, 2005..

[6]  Lawrence A. Crum,et al.  The Motion of Bubbles in a Stationary Sound Field , 1969 .

[7]  H. Pau,et al.  The increasing sclerosis of the human lens with age and its relevance to accommodation and presbyopia , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[8]  N. Amso,et al.  Contrast agent bubble and erythrocyte behavior in a 1.5-MHz standing ultrasound wave. , 2003, Ultrasound in medicine & biology.

[9]  Jeremy J. Hawkes,et al.  Force field particle filter, combining ultrasound standing waves and laminar flow , 2001 .

[10]  Douglas L. Miller.  Stable arrays of resonant bubbles in a 1‐MHz standing‐wave acoustic field , 1977 .

[11]  M. O'Donnell,et al.  Bubble-based acoustic radiation force elasticity imaging , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[12]  C. P. Lee,et al.  Acoustic radiation force on a bubble , 1993 .

[13]  William F. Walker,et al.  Sonorheometry: A Noncontact Method for the Dynamic Assessment of Thrombosis , 2004, Annals of Biomedical Engineering.

[14]  Thomas J. Asaki,et al.  Acoustic radiation force on a bubble driven above resonance , 1994 .

[15]  K. Yosioka,et al.  Acoustic radiation pressure on a compressible sphere , 1955 .

[16]  Junru Wu,et al.  Acoustic radiation force on a small compressible sphere in a focused beam , 1990 .

[17]  W F Walker,et al.  Internal deformation of a uniform elastic solid by acoustic radiation force. , 1999, The Journal of the Acoustical Society of America.

[18]  Gregg E Trahey,et al.  Acoustic radiation force impulse imaging of the mechanical properties of arteries: in vivo and ex vivo results. , 2004, Ultrasound in medicine & biology.

[19]  S. Emelianov,et al.  Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics. , 1998, Ultrasound in medicine & biology.

[20]  T. Leighton.  The Acoustic Bubble , 1994 .

[21]  G. L. Van Der Heijde,et al.  In vivo determination of the biomechanical properties of the component elements of the accommodation mechanism , 1994, Vision Research.

[22]  G. Trahey,et al.  Acoustic radiation force impulse imaging: a parametric analysis of factors affecting image quality , 2003, IEEE Symposium on Ultrasonics, 2003.

[23]  L. Gor’kov,et al.  On the forces acting on a small particle in an acoustical field in an ideal fluid , 1962 .

[24]  Lawrence A. Crum,et al.  Bjerknes forces on bubbles in a stationary sound field , 1975 .

[25]  N. Amso,et al.  Fluorescein isothiocynate-dextran uptake by chinese hamster ovary cells in a 1.5 MHz ultrasonic standing wave in the presence of contrast agent. , 2006, Ultrasound in medicine & biology.

[26]  R. Truscott,et al.  Massive increase in the stiffness of the human lens nucleus with age: the basis for presbyopia? , 2004, Molecular vision.

[27]  Gregg Trahey,et al.  Acoustic radiation force impulse imaging: in vivo demonstration of clinical feasibility. , 2002, Ultrasound in medicine & biology.

[28]  F. G. Blake.  Bjerknes Forces in Stationary Sound Fields , 1949 .

[29]  M. O'Donnell,et al.  Acoustic detection of controlled laser-induced microbubble creation in gelatin , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.