Binuclear copper complex model of tyrosinase

The synthesis is reported of a binuclear copper(I) complex 2 which exhibits the catalytic phenolase and catecholase activity of tyrosinase.

[1]  Y. Moro-oka,et al.  .mu.-.eta.2:.eta.2-Peroxo binuclear copper complex, [Cu(HB(3,5-(Me2CH)2pz)3)]2(O2) , 1989 .

[2]  K. Karlin,et al.  Copper-dioxygen chemistry: a bioinorganic challenge , 1989 .

[3]  T. N. Sorrell.  Synthetic models for binuclear copper proteins , 1989 .

[4]  D. E. Fenton.  Copper biosites: the merits of models , 1989 .

[5]  A. Martell,et al.  Oxygen insertion by a new tyrosinase model binuclear CuI macrocyclic complex , 1989 .

[6]  B. Waegell,et al.  Pyridine nucleus hydroxylation with copper oxygenase models , 1989 .

[7]  L. Casella,et al.  Synthesis and reactivity of a family of copper monooxygenase model systems , 1988 .

[8]  G. Bernardinelli,et al.  2,2'-Bis(6-(2,2'-bipyridyl))biphenyl (TET), a sterically constricted tetradentate ligand: structures and properties of it's complexes with copper(I) and copper(II) , 1988 .

[9]  M. Zoroddu,et al.  Binuclear copper(II) complexes as oxidase catalysts , 1987 .

[10]  H. Schugar,et al.  Nearly tetrahedral 1:2 complexes of copper(I), copper(II), nickel(II), cobalt(II), and zinc(II) with 2,2'-bis(2-imidazolyl)biphenyl , 1987 .

[11]  J. Thompson,et al.  Copper-catechol chemistry. Synthesis, spectroscopy, and structure of bis(3,5-di-tert-butyl-o-semiquinato)copper(II) , 1986 .

[12]  L. Thompson,et al.  Copper co-ordination chemistry of some quadridentate pyridazine and phthalazine (N4) thioether ligands. Binuclear copper(II) complexes exhibiting two-electron reduction at positive potentials , 1986 .

[13]  A. Jacobson,et al.  Interlayer chemistry between thick transition-metal oxide layers: synthesis and intercalation reactions of K[Ca2Nan-3NbnO3n+1] (3 .ltoreq. n .ltoreq. 7) , 1985 .

[14]  K. Karlin,et al.  Catecholate coordination to copper: structural characterization of a tetrachloro-o-catecholate-bridged dicopper(II) complex as a model for intermediates in copper-catalyzed oxidation of catechols , 1985 .

[15]  J. Thompson,et al.  Synthesis, spectroscopy, and structures of copper(II)-3,5-di-tert-butyl-o-semiquinone complexes , 1985 .

[16]  E. Solomon,et al.  Substrate analogue binding to the coupled binuclear copper active site in tyrosinase , 1985 .

[17]  L. Casella,et al.  The interaction of ascorbate oxidase with L-dopa, L-tyrosine and 3,4-dihydroxycinnamic acid. Evidence for irreversible damage of the enzyme during catechol oxidase activity , 1985 .

[18]  K. Kushioka.  Autoxidation of phenols catalyzed by copper(II)-ethylenediamine complexes: the reaction mechanism , 1984 .

[19]  M. Summers,et al.  Observation of distinct cadmium-113 NMR signals for complexes of nitrogen-donor chelate ligands in solution at ambient temperature , 1984 .

[20]  K. Karlin,et al.  Studies on a model copper mono-oxygenase system: peroxo–CuII binuclear intermediates in the hydroxylation of an aromatic ring , 1984 .

[21]  K. Karlin,et al.  Copper-mediated hydroxylation of an arene ― model system for the action of copper monooxygenases: structures of a binuclear Cu(I) complex and its oxygenated product , 1984 .

[22]  D. Bolus,et al.  The interaction of substituted catechols with some binuclear copper(II) compounds , 1982 .

[23]  M. Maumy,et al.  Ortho-hydroxylation selective des phenols : II - un nouveau systeme catalytique a caractere preparatif. , 1982 .

[24]  M. Maumy,et al.  Ortho-hydroxylation selective des phenols : I - vers un modele chimique simple des tyrosinases , 1982 .