Diversified Carbohydrate-Binding Lectins from Marine Resources

Marine bioresources produce a great variety of specific and potent bioactive molecules including natural organic compounds such as fatty acids, polysaccharides, polyether, peptides, proteins, and enzymes. Lectins are also one of the promising candidates for useful therapeutic agents because they can recognize the specific carbohydrate structures such as proteoglycans, glycoproteins, and glycolipids, resulting in the regulation of various cells via glycoconjugates and their physiological and pathological phenomenon through the host-pathogen interactions and cell-cell communications. Here, we review the multiple lectins from marine resources including fishes and sea invertebrate in terms of their structure-activity relationships and molecular evolution. Especially, we focus on the unique structural properties and molecular evolution of C-type lectins, galectin, F-type lectin, and rhamnose-binding lectin families.

[1]  Y. Toh,et al.  Separation of large and small granules from horseshoe crab (Tachypleus tridentatus) hemocytes and characterization of their components. , 1993, Journal of biochemistry.

[2]  Jianzhu Li,et al.  Molecular cloning and expression analysis of a F-type lectin gene from Japanese sea perch (Lateolabrax japonicus) , 2011, Molecular Biology Reports.

[3]  T. Fujita,et al.  An Ancient Lectin-Dependent Complement System in an Ascidian: Novel Lectin Isolated from the Plasma of the Solitary Ascidian, Halocynthia roretzi1 2 , 2001, The Journal of Immunology.

[4]  T. Liu,et al.  Isolation and Characterization of Proteins That Bind to Galactose, Lipopolysaccharide of Escherichia coli, and Protein A of Staphylococcus aureus from the Hemolymph of Tachypleus tridentatus * , 2000, The Journal of Biological Chemistry.

[5]  C. Hew,et al.  Antifreeze proteins of teleost fishes. , 2001, Annual review of physiology.

[6]  Kazuho Ikeo,et al.  Nematogalectin, a nematocyst protein with GlyXY and galectin domains, demonstrates nematocyte-specific alternative splicing in Hydra , 2010, Proceedings of the National Academy of Sciences.

[7]  D Eisenberg,et al.  Oligomer formation by 3D domain swapping: a model for protein assembly and misassembly. , 1997, Advances in protein chemistry.

[8]  L. Lanier.  NK cell receptors. , 1998, Annual review of immunology.

[9]  L. Cadavid,et al.  The evolution of the immune-type gene family Rhamnospondin in cnidarians. , 2011, Gene.

[10]  S. Sugawara,et al.  Alteration of gene expression induced by Silurus asotus lectin in Burkitt's lymphoma cells. , 2008, Biological & pharmaceutical bulletin.

[11]  Yuzuru Suzuki,et al.  Primary Structure and Characteristics of a Lectin from Skin Mucus of the Japanese Eel Anguilla japonica * , 2002, The Journal of Biological Chemistry.

[12]  N. Yamasaki,et al.  Amino Acid Sequence and Carbohydrate-binding Analysis of the N-acetyl-D-galactosamine-specific C-Type Lectin, CEL-I, from the Holothuroidea, Cucumaria echinata , 2002, Bioscience, biotechnology, and biochemistry.

[13]  K. Muramoto,et al.  Purification and properties of agglutinins from conger eel, Conger Myriaster (Brevoort), skin mucus. , 1988, Developmental and comparative immunology.

[14]  S. Wai,et al.  Horseshoe crab acetyl group-recognizing lectins involved in innate immunity are structurally related to fibrinogen. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Hiroaki Tateno,et al.  Tissue-specific Expression of Rhamnose-binding Lectins in the Steelhead Trout (Oncorhynchus mykiss) , 2002, Bioscience, biotechnology, and biochemistry.

[16]  S. Kawabata,et al.  Role of lectins in the innate immunity of horseshoe crab. , 1999, Developmental and comparative immunology.

[17]  T. Ogawa,et al.  Structural characterization of a rhamnose-binding glycoprotein (lectin) from Spanish mackerel (Scomberomorous niphonius) eggs. , 2007, Biochimica et biophysica acta.

[18]  S. Leys,et al.  Isolation and cloning of a C-type lectin from the hexactinellid sponge Aphrocallistes vastus: a putative aggregation factor. , 2001, Glycobiology.

[19]  P. Seeberger,et al.  Plumieribetin, a Fish Lectin Homologous to Mannose-binding B-type Lectins, Inhibits the Collagen-binding α1β1 Integrin* , 2009, The Journal of Biological Chemistry.

[20]  T. Ogawa,et al.  Isolation and characterization of L-rhamnose-binding lectins from chum salmon (Oncorhynchus keta) eggs , 2002 .

[21]  W. Weis,et al.  The C‐type lectin superfamily in the immune system , 1998, Immunological reviews.

[22]  B. Weston,et al.  Structure–function relationships of the extracellular domain of the autosomal dominant polycystic kidney disease‐associated protein, polycystin‐1 , 2003, FEBS letters.

[23]  C. Freitag,et al.  A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. , 2010, Molecular psychiatry.

[24]  S. Tsutsui,et al.  Yeast-binding C-type lectin with opsonic activity from conger eel (Conger myriaster) skin mucus. , 2007, Molecular immunology.

[25]  T. Ogawa,et al.  Opsonic effect of congerin, a mucosal galectin of the Japanese conger, Conger myriaster (Brevoort). , 2006, Fish & shellfish immunology.

[26]  K. Muramoto,et al.  Galectin containing cells in the skin and mucosal tissues in Japanese conger eel, Conger myriaster: an immunohistochemical study. , 2001, Developmental and comparative immunology.

[27]  H. Sugimoto,et al.  Crystal structure and mutational analysis of Ca2+-independent type II antifreeze protein from longsnout poacher, Brachyopsis rostratus. , 2008, Journal of molecular biology.

[28]  S. Kawabata,et al.  A Newly Identified Horseshoe Crab Lectin with Specificity for Blood Group A Antigen Recognizes Specific O-Antigens of Bacterial Lipopolysaccharides* , 1999, The Journal of Biological Chemistry.

[29]  G. Levi,et al.  Isolation and physicochemical characterization of electrolectin, a beta-D-galactoside binding lectin from the electric organ of Electrophorus electricus. , 1981, The Journal of biological chemistry.

[30]  S. Sugawara,et al.  Purification, characterization, cDNA cloning, and expression of asialofetuin-binding C-type lectin from eggs of shishamo smelt (Osmerus [Spirinchus] lanceolatus). , 2005, Biochimica et biophysica acta.

[31]  T. Takagi,et al.  A calcium-dependent galactose-binding lectin from the tunicate Polyandrocarpa misakiensis. Isolation, characterization, and amino acid sequence. , 1989, The Journal of biological chemistry.

[32]  K. Murayama,et al.  Tandem repeat structure of rhamnose-binding lectin from catfish (Silurus asotus) eggs. , 1999, Biochimica et biophysica acta.

[33]  T. Ogawa,et al.  Rhamnose-binding Lectins from Steelhead Trout (Oncorhynchus mykiss) Eggs Recognize Bacterial Lipopolysaccharides and Lipoteichoic Acid , 2002, Bioscience, biotechnology, and biochemistry.

[34]  T. E. Petersen,et al.  The amino‐terminal domain of thrombomodulin and pancreatic stone protein are homologous with lectins , 1988, FEBS letters.

[35]  G. Vasta,et al.  Characterization of a Binary Tandem Domain F-type Lectin from Striped Bass (Morone saxatilis)* , 2006, Journal of Biological Chemistry.

[36]  S. Kijimoto-Ochiai,et al.  CD23 (the low-affinity IgE receptor) as a C-type lectin: a multidomain and multifunctional molecule , 2002, Cellular and Molecular Life Sciences CMLS.

[37]  T. Ogawa,et al.  Accelerated evolution in the protein-coding region of galectin cDNAs, congerin I and congerin II, from skin mucus of conger eel (Conger myriaster). , 1999, Bioscience, biotechnology, and biochemistry.

[38]  A. Kuno,et al.  Lectin microarray analysis of pluripotent and multipotent stem cells , 2011, Genes to cells : devoted to molecular & cellular mechanisms.

[39]  J. Dagorn,et al.  Pancreatic Lithostathine as a Calcite Habit Modifier* , 1996, The Journal of Biological Chemistry.

[40]  D. Kilpatrick.  Animal lectins: a historical introduction and overview. , 2002, Biochimica et biophysica acta.

[41]  B. Diehl-seifert,et al.  A galectin links the aggregation factor to cells in the sponge (Geodia cydonium) system. , 1996, Glycobiology.

[42]  S. Kawabata,et al.  A Novel Type of limulus Lectin-L6. PURIFICATION, PRIMARY STRUCTURE, AND ANTIBACTERIAL ACTIVITY (*) , 1995, The Journal of Biological Chemistry.

[43]  T. Shirai,et al.  Protein engineering of conger eel galectins by tracing of molecular evolution using probable ancestral mutants , 2010, BMC Evolutionary Biology.

[44]  Y. Yamaguchi,et al.  Lecticans: organizers of the brain extracellular matrix , 2000, Cellular and Molecular Life Sciences CMLS.

[45]  J. D. Haddow,et al.  Isolation of the salmonid rhamnose-binding lectin STL2 from spores of the microsporidian fish parasite Loma salmonae. , 2005, Journal of fish diseases.

[46]  K. Muramoto,et al.  The amino-acid sequence of multiple lectins of the acorn barnacle Megabalanus rosa and its homology with animal lectins. , 1990, Biochimica et biophysica acta.

[47]  Yuzuru Suzuki,et al.  Tandem repeat L-rhamnose-binding lectin from the skin mucus of ponyfish, Leiognathus nuchalis. , 2005, Biochemical and biophysical research communications.

[48]  Se-kwon Kim,et al.  Potential Anti-HIV Agents from Marine Resources: An Overview , 2010, Marine drugs.

[49]  K. Muramoto,et al.  Possible immune functions of congerin, a mucosal galectin, in the intestinal lumen of Japanese conger eel. , 2007, Fish & shellfish immunology.

[50]  H. Yako,et al.  Participation of the C-type hemolymph lectin in mineralization of the acorn barnacle Megabalanusrosa , 2002 .

[51]  L. Visai,et al.  Structural and biochemical characterization of a new type of lectin isolated from carp eggs. , 2003, The Biochemical journal.

[52]  T. Shirai,et al.  Reconstruction of a probable ancestral form of conger eel galectins revealed their rapid adaptive evolution process for specific carbohydrate recognition. , 2007, Molecular biology and evolution.

[53]  L. Amzel,et al.  Structure and specificity of a binary tandem domain F-lectin from striped bass (Morone saxatilis). , 2010, Journal of molecular biology.

[54]  K. Titani,et al.  Purification and characterization of two Ca(2+)-dependent lectins from coelomic plasma of sea cucumber, Stichopus japonicus. , 1994, Journal of biochemistry.

[55]  S. Tosatto,et al.  Immune roles of a rhamnose-binding lectin in the colonial ascidian Botryllus schlosseri. , 2011, Immunobiology.

[56]  K. Murayama,et al.  COMPARISON OF N-TERMINAL AMINO ACID SEQUENCE OF FISH ROE RHAMNOSE-BINDING LECTINS , 1992 .

[57]  W. Sawyer,et al.  Purification and characterization of a galactan-reactive agglutinin from the clam Tridacna maxima (Röding) and a study of its combining site. , 1978, The Biochemical journal.

[58]  W. Jia,et al.  Molecular cloning of rhamnose-binding lectin gene and its promoter region from snakehead Channa argus , 2010, Fish Physiology and Biochemistry.

[59]  E. Grishin,et al.  α-Latrotoxin Receptor, Latrophilin, Is a Novel Member of the Secretin Family of G Protein-coupled Receptors* , 1997, The Journal of Biological Chemistry.

[60]  S. Kawabata,et al.  Purification, characterization, and cDNA cloning of alpha-N-acetylgalactosamine-specific lectin from starfish, Asterina pectinifera. , 2002, Glycobiology.

[61]  M. Fritz,et al.  Purification and characterization of perlucin and perlustrin, two new proteins from the shell of the mollusc Haliotis laevigata. , 2000, Biochemical and biophysical research communications.

[62]  R. Sakai,et al.  Purification, cloning and characterization of egg lectins from the teleost Tribolodon brandti. , 2007, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[63]  G. Vasta,et al.  F-type lectin from the sea bass (Dicentrarchus labrax): purification, cDNA cloning, tissue expression and localization, and opsonic activity. , 2009, Fish & shellfish immunology.

[64]  B. Spolaore,et al.  Novel rhamnose-binding lectins from the colonial ascidian Botryllus schlosseri. , 2008, Developmental and comparative immunology.

[65]  Y. Shimizu,et al.  Marine biopolymers with cell specificity. II. Purification and characterization of agglutinins from mucus of windowpane flounder Lophopsetta maculata. , 1980, Biochimica et biophysica acta.

[66]  R. Criddle,et al.  Purification and properties of a hemagglutination factor from Arabian Gulf catfish (Arius thalassinus) epidermal secretion. , 1986, Comparative biochemistry and physiology. B, Comparative biochemistry.

[67]  K. Drickamer,et al.  Genomic analysis of C-type lectins. , 2002, Biochemical Society symposium.

[68]  D Eisenberg,et al.  3D domain swapping: A mechanism for oligomer assembly , 1995, Protein science : a publication of the Protein Society.

[69]  R. Huber,et al.  The 2.0-Å crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[70]  Ruben T. Almaraz,et al.  Gas-phase scrambling of disulfide bonds during matrix-assisted laser desorption/ionization mass spectrometry analysis , 2009, Journal of the American Society for Mass Spectrometry.

[71]  Osamu Nakamura,et al.  The function of rhamnose-binding lectin in innate immunity by restricted binding to Gb3. , 2009, Developmental and comparative immunology.

[72]  H. Yokosawa,et al.  A unique primary structure, cDNA cloning and function of a galactose-specific lectin from ascidian plasma. , 1999, European journal of biochemistry.

[73]  K. Drickamer.  Ca2+-dependent carbohydrate-recognition domains in animal proteins , 1993 .

[74]  S. Hirose,et al.  Structure, properties and enhanced expression of galactose-binding C-type lectins in mucous cells of gills from freshwater Japanese eels (Anguilla japonica). , 2001, The Biochemical journal.

[75]  T. Ogawa,et al.  Immunohistochemical localization of rhamnose-binding lectins in the steelhead trout (Oncorhynchus mykiss). , 2002, Developmental and comparative immunology.

[76]  N. Yamasaki,et al.  Amino acid sequence of a C-type lectin CEL-IV from the marine invertebrate Cucumaria echinata. , 1995, Bioscience, biotechnology, and biochemistry.

[77]  H. Tateno.  SUEL-Related Lectins, a Lectin Family Widely Distributed throughout Organisms , 2010, Bioscience, biotechnology, and biochemistry.

[78]  T. Ogawa,et al.  Comparison of the amino acid sequences of acorn barnacle lectins showing different inhibitory activities toward the crystal growth of calcium carbonate , 2001 .

[79]  D. Rogers,et al.  A galactose-specific lectin from the red marine alga Ptilota filicina. , 1998, Phytochemistry.

[80]  N. Yamasaki,et al.  Interaction of the Hemolytic Lectin CEL-III from the Marine Invertebrate Cucumaria echinata with the Erythrocyte Membrane (*) , 1995, The Journal of Biological Chemistry.

[81]  K. Muramoto,et al.  The amino-acid sequence of a lectin from conger eel, Conger myriaster, skin mucus. , 1992, Biochimica et biophysica acta.

[82]  Wei-Jun Yang,et al.  Characteristics and primary structure of a galectin in the skin mucus of the Japanese eel, Anguilla japonica. , 2004, Developmental and comparative immunology.

[83]  A. Ikai,et al.  The complete amino acid sequence of echinoidin, a lectin from the coelomic fluid of the sea urchin Anthocidaris crassispina. Homologies with mammalian and insect lectins. , 1987, The Journal of biological chemistry.

[84]  Douglas N W Cooper,et al.  Galectinomics: finding themes in complexity. , 2002, Biochimica et biophysica acta.

[85]  H. Ahmed,et al.  Galectins in teleost fish: Zebrafish (Danio rerio) as a model species to address their biological roles in development and innate immunity , 2004, Glycoconjugate Journal.

[86]  T. Shirai,et al.  Structure based studies of the adaptive diversification process of congerins , 2006, Molecular Diversity.

[87]  T. Ogawa,et al.  Distribution and Molecular Evolution of Rhamnose-binding Lectins in Salmonidae: Isolation and Characterization of Two Lectins from White-spotted Charr (Salvelinus leucomaenis) Eggs , 2002, Bioscience, biotechnology, and biochemistry.

[88]  K. Strupat,et al.  Comparative investigations on the amino-acid sequences of different isolectins from the sponge Axinella polypoides (Schmidt). , 1992, Biochimica et biophysica acta.

[89]  J. Bujnicki,et al.  Structure and Evolutionary Origin of Ca2+-Dependent Herring Type II Antifreeze Protein , 2007, PloS one.

[90]  A. Hughes,et al.  A gene family of putative immune recognition molecules in the hydroid Hydractinia , 2007, Immunogenetics.

[91]  J. Gready,et al.  The C‐type lectin‐like domain superfamily , 2005, The FEBS journal.

[92]  N. Yamasaki,et al.  Purification and characterization of four Ca(2+)-dependent lectins from the marine invertebrate, Cucumaria echinata. , 1994, Journal of biochemistry.

[93]  N. Yamasaki,et al.  Amino acid sequence of a lectin from the sea cucumber, Stichopus japonicus, and its structural relationship to the C-type animal lectin family. , 1994, Journal of biochemistry.

[94]  K. Muramoto,et al.  The amino-acid sequence of a lectin of the acorn barnacle Megabalanus rosa , 1986 .

[95]  Takeshi Yamamoto,et al.  Molecular Cloning, Expression and Properties of an α/β-Galactoside α2,3-Sialyltransferase from Vibrio sp. JT-FAJ-16 , 2007 .

[96]  R. Huber,et al.  Tachylectin‐2: crystal structure of a specific GlcNAc/GalNAc‐binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus , 1999, The EMBO journal.

[97]  B. Mikami,et al.  Structural basis of a fungal galectin from Agrocybe cylindracea for recognizing sialoconjugate. , 2005, Journal of molecular biology.

[98]  T. Ogawa,et al.  Functional and structural characterization of multiple galectins from the skin mucus of conger eel, Conger myriaster. , 1999, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[99]  M. Ohwaki,et al.  Studies on lectins of amago (Oncorhyncus rhodurus). I. Amago ova lectin and its receptor on homologous macrophages. , 1983, Developmental and comparative immunology.

[100]  T. Ogawa,et al.  A Novel Rhamnose-binding Lectin Family from Eggs of Steelhead Trout (Oncorhynchus mykiss) with Different Structures and Tissue Distribution , 2001, Bioscience, biotechnology, and biochemistry.

[101]  S. Kawabata,et al.  Purification, Characterization, and cDNA Cloning of a 27-kDa Lectin (L10) from Horseshoe Crab Hemocytes (*) , 1995, The Journal of Biological Chemistry.

[102]  M. Künzler,et al.  Structural basis for chitotetraose coordination by CGL3, a novel galectin-related protein from Coprinopsis cinerea. , 2008, Journal of molecular biology.

[103]  M. Taylor,et al.  Biology of animal lectins. , 1993, Annual review of cell biology.

[104]  H. Gabius.  Animal lectins. , 1997, European journal of biochemistry.

[105]  S. Pomponi,et al.  Isolation and characterization of niphatevirin, a human-immunodeficiency-virus-inhibitory glycoprotein from the marine sponge Niphates erecta. , 1997, European journal of biochemistry.

[106]  S. Tsutsui,et al.  A unique epidermal mucus lectin identified from catfish (Silurus asotus): first evidence of intelectin in fish skin slime. , 2011, Journal of biochemistry.

[107]  J. Hirabayashi,et al.  Isolation and characterization of l-rhamnose-binding lectin, which binds to microsporidian Glugea plecoglossi, from ayu (Plecoglossus altivelis) eggs. , 2008, Developmental and comparative immunology.

[108]  Andreas Russ,et al.  Solution Structure and Sugar-Binding Mechanism of Mouse Latrophilin-1 RBL: a 7TM Receptor-Attached Lectin-Like Domain , 2008, Structure.

[109]  Phillip C. Wright,et al.  Marine cyanobacteria—a prolific source of natural products , 2001 .

[110]  S. Sugawara,et al.  Catfish egg lectin causes rapid activation of multidrug resistance 1 P-glycoprotein as a lipid translocase. , 2005, Biological & pharmaceutical bulletin.

[111]  H. Ahmed,et al.  Biochemical and molecular characterization of galectins from zebrafish (Danio rerio): notochord-specific expression of a prototype galectin during early embryogenesis. , 2003, Glycobiology.

[112]  M. Kashiwagi,et al.  Multiplicity, Structures, and Endocrine and Exocrine Natures of Eel Fucose-binding Lectins* , 2000, The Journal of Biological Chemistry.

[113]  S. Iwanaga.  The molecular basis of innate immunity in the horseshoe crab. , 2002, Current opinion in immunology.

[114]  Hafiz Ahmed,et al.  Structural and functional diversity of lectin repertoires in invertebrates, protochordates and ectothermic vertebrates. , 2004, Current opinion in structural biology.

[115]  N. Woo,et al.  The immunostimulatory activity and stability of grass carp (Ctenopharyngodon idellus) roe lectin. , 2003, Veterinary immunology and immunopathology.

[116]  Takeshi Yamamoto,et al.  Purification, Cloning, and Expression of an α/β-Galactoside α-2,3-Sialyltransferase from a Luminous Marine Bacterium, Photobacterium phosphoreum* , 2007, Journal of Biological Chemistry.

[117]  K. Titani,et al.  Amino acid sequence and molecular characterization of a D-galactoside-specific lectin purified from sea urchin (Anthocidaris crassispina) eggs. , 1991, Biochemistry.

[118]  C. Lingwood.  Role of verotoxin receptors in pathogenesis. , 1996, Trends in microbiology.

[119]  A. Desbois,et al.  Conventional and Unconventional Antimicrobials from Fish, Marine Invertebrates and Micro-algae , 2010, Marine drugs.

[120]  T. Yamane,et al.  High-resolution structure of the conger eel galectin, congerin I, in lactose-liganded and ligand-free forms: emergence of a new structure class by accelerated evolution. , 1999, Structure.

[121]  G. Vasta,et al.  A Galectin of Unique Domain Organization from Hemocytes of the Eastern Oyster (Crassostrea virginica) Is a Receptor for the Protistan Parasite Perkinsus marinus12 , 2007, The Journal of Immunology.

[122]  N. Kiyokawa,et al.  A Role for Lipid Rafts in Immune Cell Signaling , 2001, Microbiology and immunology.

[123]  T. Fujita,et al.  Cloning and Characterization of Novel Ficolins from the Solitary Ascidian, Halocynthia roretzi* , 2001, The Journal of Biological Chemistry.

[124]  R. Stockert,et al.  The asialoglycoprotein receptor: relationships between structure, function, and expression. , 1995, Physiological reviews.

[125]  H. Sarles,et al.  Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice. , 1987, European journal of biochemistry.

[126]  K. Drickamer,et al.  Two distinct classes of carbohydrate-recognition domains in animal lectins. , 1988, The Journal of biological chemistry.

[127]  Yuzuru Suzuki,et al.  Lectins Homologous to Those of Monocotyledonous Plants in the Skin Mucus and Intestine of Pufferfish, Fugu rubripes* , 2003, Journal of Biological Chemistry.

[128]  J. Wrana,et al.  The Slit Receptor EVA-1 Coactivates a SAX-3/Robo–Mediated Guidance Signal in C. elegans , 2007, Science.

[129]  T. Yamane,et al.  Crystal structure of a conger eel galectin (congerin II) at 1.45A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication. , 2002, Journal of molecular biology.

[130]  J. Hirabayashi,et al.  Isolation, characterization and molecular evolution of a novel pearl shell lectin from a marine bivalve, Pteria penguin , 2006, Molecular Diversity.

[131]  S. Kawabata,et al.  A Newly Identified Horseshoe Crab Lectin with Binding Specificity to O-antigen of Bacterial Lipopolysaccharides* , 1997, The Journal of Biological Chemistry.

[132]  T. Fujita,et al.  The lectin‐complement pathway – its role in innate immunity and evolution , 2004, Immunological reviews.

[133]  S. Kawabata,et al.  Purification, Characterization, and Amino Acid Sequence of an Embryonic Lectin in Perivitelline Fluid of the Horseshoe Crab* , 1999, The Journal of Biological Chemistry.

[134]  S. Sugawara,et al.  [Regulation of globotriaosylceramide (Gb3)-mediated signal transduction by rhamnose-binding lectin]. , 2007, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[135]  H. Ahmed,et al.  Unlike mammalian GRIFIN, the zebrafish homologue (DrGRIFIN) represents a functional carbohydrate-binding galectin. , 2007, Biochemical and biophysical research communications.

[136]  Pablo Engel,et al.  The selecting: vascular adhesion molecules , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[137]  J. Gready,et al.  C-type lectin-like domains in Fugu rubripes , 2004, BMC Genomics.

[138]  T. Ogawa.  Molecular diversity of proteins in biological offense and defense systems , 2006, Molecular Diversity.

[139]  Tomohisa Ogawa,et al.  Structure of rhamnose-binding lectin CSL3: unique pseudo-tetrameric architecture of a pattern recognition protein. , 2009, Journal of molecular biology.

[140]  H. Ahmed,et al.  Knockdown of a galectin-1-like protein in zebrafish (Danio rerio) causes defects in skeletal muscle development , 2009, Glycoconjugate Journal.

[141]  L. Amzel,et al.  A novel fucose recognition fold involved in innate immunity , 2002, Nature Structural Biology.

[142]  Barry R O'Keefe,et al.  Isolation and Characterization of Griffithsin, a Novel HIV-inactivating Protein, from the Red Alga Griffithsia sp.* , 2005, Journal of Biological Chemistry.

[143]  T. Ogawa,et al.  Isolation and Characterization of Rhamnose-binding Lectins from Eggs of Steelhead Trout (Oncorhynchus mykiss) Homologous to Low Density Lipoprotein Receptor Superfamily* , 1998, The Journal of Biological Chemistry.