The Inflammatory Response

VASCULAR RESPONSE TO INFLAMMATION 119 Increased Vascular Permeability............................................................... 119 Methods of Estimating Increased Vascular Permeability 119 STRUCTURAL ASPECTS OF INCREASED VASCULAR PERMEABILITY.1 Ultrastructure of the Normal Capillary and Venule.120 Ultrastructure of Abnormally Permeable Capillaries and Venules.122 Molecular Sieving.123 Basement Membrane in Vascular Permeability.124 Filtration Pressure and Increased Permeability................................................. 125 Phagocytic Activity in Stimulated Vascular Endothelium........................................ 126 DIRECT DAMAGE AND CHEMICAL MEDIATORS AS MECHANISMS OF THE INFLAMMATORY RESPONSE .... 126 ENDOGENOUS SUBSTANCES IN THE EARLY INFLAMMATORY REACTION............................. 127 Histamine.................................................................................... 127 Mechanism of Histamine Release .............................................................. 129 Serotonin.............................................................................. 129 ENDOGENOUS MECHANISMS POSSIBLY RESPONSIBLE FOR THE DELAYED VASCULAR CHANGES OF INJURY.................................................................................... 130 Polypeptides ............................................................................ 130 Permeability-Increasing Globulins (PF/DIL) .................................................. 131 Inhibitors.................................................................................... 132 ROLE OF POLYPEPTIDES, PLASMA KININS, KININ-FORMING ENZYMES, AND GLOBULIN PF IN INFLAM-