The role of magnetic resonance imaging in the management of acute spinal cord injury.

Magnetic resonance imaging (MRI) has become the gold standard for imaging neurological tissues including the spinal cord. The use of MRI for imaging in the acute management of patients with spinal cord injury has increased significantly. This paper used a vigorous literature review with Downs and Black scoring, followed by a Delphi vote on the main conclusions. MRI is strongly recommended for the prognostication of acute spinal cord injury. The sagittal T2 sequence was particularly found to be of value. Four prognostication patterns were found to be predictive of neurological outcome (normal, single-level edema, multi-level edema, and mixed hemorrhage and edema). It is recommended that MRI be used to direct clinical decision making. MRI has a role in clearance, the ruling out of injury, of the cervical spine in the obtunded patient only if there is abnormality of the neurological exam. Patients with cervical spinal cord injuries have an increased risk of vertebral artery injuries but the literature does not allow for recommendation of magnetic resonance angiography as part of the routine protocol. Finally, time repetition (TR) and time echo (TE) values used to evaluate patients with acute spinal cord injury vary significantly. All publications with MRI should specify the TR and TE values used.

[1]  M. Olona,et al.  Clinical and magnetic resonance imaging correlation in acute spinal cord injury , 1997, Spinal Cord.

[2]  S. Emery,et al.  Magnetic resonance imaging of posttraumatic spinal ligament injury. , 1989, Journal of spinal disorders.

[3]  R. Marino,et al.  The relationship between the functional abilities of patients with cervical spinal cord injury and the severity of damage revealed by MR imaging. , 1999, AJNR. American journal of neuroradiology.

[4]  S. Satya‐Murti Evidence-based Medicine: How to Practice and Teach EBM , 1997 .

[5]  A. Minami,et al.  Diagnostic accuracy of magnetic resonance imaging for detecting posterior ligamentous complex injury associated with thoracic and lumbar fractures. , 2003, Journal of neurosurgery.

[6]  J. Carrino,et al.  Incidence of vertebral artery thrombosis in cervical spine trauma: correlation with severity of spinal cord injury. , 2005, AJNR. American journal of neuroradiology.

[7]  A. Nowitzke,et al.  Autologous olfactory ensheathing cell transplantation in human spinal cord injury. , 2005, Brain : a journal of neurology.

[8]  Brian D Schmit,et al.  A new technique for imaging the human spinal cord in vivo. , 2006, Biomedical sciences instrumentation.

[9]  L. Dai,et al.  Central Cord Injury Complicating Acute Cervical Disc Herniation in Trauma , 2000, Spine.

[10]  S. Terae,et al.  Gd-DTPA-enhanced MR imaging of injured spinal cord. , 1997, Clinical imaging.

[11]  P. Walczak,et al.  MR imaging of lineage-restricted neural precursors following transplantation into the adult spinal cord , 2006, Experimental Neurology.

[12]  Chris A Clark,et al.  Diffusion tensor imaging in spinal cord: methods and applications – a review , 2002, NMR in biomedicine.

[13]  J. Provenzale MR imaging of spinal trauma , 2007, Emergency Radiology.

[14]  T. Albert,et al.  Efficacy of magnetic resonance imaging in the evaluation of posterior cervical spine fractures. , 1999, Spine.

[15]  R. Zimmerman,et al.  MRI in the assessment of the supportive soft tissues of the cervical spine in acute trauma in children , 1998, Neuroradiology.

[16]  C. Schaller,et al.  Vertebral artery injury after cervical spine trauma: a prospective study. , 2002, Zentralblatt fur Neurochirurgie.

[17]  J. Castellanos,et al.  Vertebral artery occlusion after acute cervical spine trauma. , 2000, Spine.

[18]  B. Aarabi,et al.  Acute cervical traumatic spinal cord injury: MR imaging findings correlated with neurologic outcome--prospective study with 100 consecutive patients. , 2007, Radiology.

[19]  C. Sliker,et al.  Assessing cervical spine stability in obtunded blunt trauma patients: review of medical literature. , 2005, Radiology.

[20]  P. Mccormick Emergency Magnetic Resonance Imaging of Cervical Spinal Cord Injuries: Clinical Correlation and Prognosis , 1999 .

[21]  B. Sanchez,et al.  Magnetic resonance imaging is not needed to clear cervical spines in blunt trauma patients with normal computed tomographic results and no motor deficits. , 2005, Archives of surgery.

[22]  P. Foster,et al.  Cellular Imaging of Inflammation after Experimental Spinal Cord Injury , 2005, Molecular imaging.

[23]  E. D. Schwartz,et al.  The Impact of Methylprednisolone on Lesion Severity Following Spinal Cord Injury , 2007, Spine.

[24]  K. Kaneda,et al.  Traumatically Induced Vertebral Artery Occlusion Associated with Cervical Spine Injuries: Prospective Study Using Magnetic Resonance Angiography , 2005, Spine.

[25]  S. Govender,et al.  Vertebral artery injury in cervical spine trauma. , 2001, Injury.

[26]  A. Flanders,et al.  Vertebral artery injury after acute cervical spine trauma: rate of occurrence as detected by MR angiography and assessment of clinical consequences. , 1995, AJR. American journal of roentgenology.

[27]  H. Lee,et al.  Reliability of Magnetic Resonance Imaging in Detecting Posterior Ligament Complex Injury in Thoracolumbar Spinal Fractures , 2000, Spine.

[28]  K. Tsuchiya,et al.  Value of diffusion-weighted MR imaging in acute cervical cord injury as a predictor of outcome , 2006, Neuroradiology.

[29]  James S. Anderson,et al.  Is magnetic resonance imaging essential in clearing the cervical spine in obtunded patients with blunt trauma? , 2007, The Journal of trauma.

[30]  M. Kulkarni,et al.  Acute Spinal Cord Injury: A Study Using Physical Examination and Magnetic Resonance Imaging , 1990 .

[31]  C. Spettell,et al.  Forecasting motor recovery after cervical spinal cord injury: value of MR imaging. , 1996, Radiology.

[32]  J. Caillé,et al.  Normal and disrupted lumbar longitudinal ligaments: correlative MR and anatomic study. , 1989, Radiology.

[33]  R. Alday,et al.  Brown-Sequard syndrome after blunt cervical spine trauma: clinical and radiological correlations , 2007, European Spine Journal.

[34]  Carol S. Beatty,et al.  Acute cervical spine injuries: prospective MR imaging assessment at a level 1 trauma center. , 1999, Radiology.

[35]  B. Min,et al.  Complete Spinal Cord Injury Treatment Using Autologous Bone Marrow Cell Transplantation and Bone Marrow Stimulation with Granulocyte Macrophage‐Colony Stimulating Factor: Phase I/II Clinical Trial , 2007, Stem cells.

[36]  R. S. Hinks,et al.  Comparison of gradient-recalled-echo and T2-weighted spin-echo pulse sequences in intramedullary spinal lesions. , 1989, AJNR. American journal of neuroradiology.

[37]  Lou M. Smith,et al.  An Analysis of Eastern Association for the Surgery of Trauma Practice Guidelines for Cervical Spine Evaluation in a Series of Patients with Multiple Imaging Techniques , 2002, The American surgeon.

[38]  R. Gullapalli,et al.  Diffusion Tensor MR Imaging in Cervical Spine Trauma , 2008, American Journal of Neuroradiology.

[39]  J. Mcelhaney,et al.  Acute spinal ligament disruption: MR imaging with anatomic correlation , 1993, Journal of magnetic resonance imaging : JMRI.

[40]  K. Linnau,et al.  Correlation of MR imaging findings with intraoperative findings after cervical spine trauma. , 2007, AJNR. American journal of neuroradiology.

[41]  K. Shimada,et al.  Sequential MR studies of cervical cord injury: correlation with neurological damage and clinical outcome , 1999, Spinal Cord.

[42]  T. Albert,et al.  Long‐Term Evaluation of Vertebral Artery Injuries Following Cervical Spine Trauma Using Magnetic Resonance Angiography , 1998, Spine.

[43]  N. Black,et al.  The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. , 1998, Journal of epidemiology and community health.

[44]  K. Song,et al.  The Efficacy of the Modified Classification System of Soft Tissue Injury in Extension Injury of the Lower Cervical Spine , 2008, Spine.

[45]  T. Kossmann,et al.  Clinical outcomes of magnetic resonance imaging in blunt cervical trauma , 2007, Emergency medicine Australasia : EMA.

[46]  G. Gualdi,et al.  MRI in the acute phase of spinal cord traumatic lesions: Relationship between MRI findings and neurological outcome. , 2005, La Radiologia medica.

[47]  P. Narayana,et al.  1.5 tesla magnetic resonance imaging of acute spinal trauma. , 1988, Radiographics : a review publication of the Radiological Society of North America, Inc.

[48]  P. London Injury , 1969, Definitions.

[49]  J. Cuschieri,et al.  Clearing the Cervical Spine in Victims of Blunt Assault to the Head and Neck: What is Necessary? , 2000, The American surgeon.

[50]  Huiyong Shen,et al.  Applications of diffusion-weighted MRI in thoracic spinal cord injury without radiographic abnormality , 2007, International Orthopaedics.

[51]  J. Soto,et al.  Fast spin echo vs conventional spin echo in cervical spine imaging , 1997, European Radiology.

[52]  Sharon E Straus,et al.  Evidence-Based Medicine: How to Practice and Teach It , 2010 .

[53]  P. Schmalbrock,et al.  Hypertonic saline attenuates cord swelling and edema in experimental spinal cord injury: A study utilizing magnetic resonance imaging* , 2009, Critical care medicine.

[54]  J. Peduzzi,et al.  Olfactory Mucosa Autografts in Human Spinal Cord Injury: A Pilot Clinical Study , 2006, The journal of spinal cord medicine.