Evidence for a key role of leptin in osteoarthritis.
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D. Loeuille | P. Netter | D. Mainard | B. Terlain | H. Dumond | N. Presle | P. Pottie
[1] Patricia Ducy,et al. Leptin Regulates Bone Formation via the Sympathetic Nervous System , 2002, Cell.
[2] W. B. van den Berg,et al. Inhibition of Endogenous TGF-β During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair , 2002, The Journal of Immunology.
[3] M. Phillip,et al. Leptin Acts as a Growth Factor on the Chondrocytes of Skeletal Growth Centers , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[4] D. Heymann,et al. Recent advances in TGF-β effects on chondrocyte metabolism , 2002 .
[5] K. Satomura,et al. Potential Role of Leptin in Endochondral Ossification , 2002, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[6] R. Faggioni,et al. Leptin regulation of the immune response and the immunodeficiency of malnutrition 1 , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[7] John P Allegrante,et al. Body mass indices in patients with disabling hip osteoarthritis , 2001, Arthritis research.
[8] G. Knutsen,et al. Human articular chondrocytes express functional leptin receptors. , 2001, Biochemical and biophysical research communications.
[9] J. Whitfield,et al. Leptin: brains and bones , 2001, Expert opinion on investigational drugs.
[10] P. Jones,et al. Leptin and its role in lipid metabolism , 2001, Current opinion in lipidology.
[11] Richard M Aspden,et al. Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism , 2001, The Lancet.
[12] P. Sime,et al. Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation. , 2001, Osteoarthritis and cartilage.
[13] G. Fantuzzi,et al. Leptin in the regulation of immunity, inflammation, and hematopoiesis , 2000, Journal of leukocyte biology.
[14] J. Pelletier,et al. Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor β: Role of furin convertase , 2000 .
[15] C. Steppan,et al. Leptin is a potent stimulator of bone growth in ob/ob mice , 2000, Regulatory Peptides.
[16] H. Minehara,et al. Growth Factor Expression in the Osteophytes of the Human Femoral Head in Osteoarthritis , 2000, Clinical orthopaedics and related research.
[17] J. Vincent,et al. Binding of a pure 125I-monoiodoleptin analog to mouse tissues: a developmental study , 2000, Peptides.
[18] Arndt F Schilling,et al. Leptin Inhibits Bone Formation through a Hypothalamic Relay A Central Control of Bone Mass , 2000, Cell.
[19] Y. Iwamoto,et al. Expression of insulin-like growth factor I messenger ribonucleic acid in developing osteophytes in murine experimental osteoarthritis and in rats inoculated with growth hormone-secreting tumor. , 1999, Endocrinology.
[20] A. Loudon,et al. Leptin actions on food intake and body temperature are mediated by IL-1. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[21] J. Sieper,et al. Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage. , 1999, The Journal of rheumatology.
[22] D. Felson,et al. Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. , 1999, Epidemiology.
[23] Y. Guisez,et al. Leptin Is an Endogenous Protective Protein against the Toxicity Exerted by Tumor Necrosis Factor , 1999, The Journal of experimental medicine.
[24] G. Garcı́a-Cardeña,et al. Biological action of leptin as an angiogenic factor. , 1998, Science.
[25] W. B. van den Berg,et al. Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints. , 1998, Laboratory investigation; a journal of technical methods and pathology.
[26] C. Elson,et al. Chondrocyte tumor necrosis factor receptors and focal loss of cartilage in osteoarthritis. , 1997, Osteoarthritis and cartilage.
[27] N. Hoggard,et al. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[28] R. Mason,et al. Chondrocyte cytokine and growth factor expression in murine osteoarthritis. , 1997, Osteoarthritis and cartilage.
[29] K. Moar,et al. Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. , 1997, Biochemical and biophysical research communications.
[30] T. Aigner,et al. Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage. , 1997, Arthritis and rheumatism.
[31] K. Mounzih,et al. Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin , 1997, Science.
[32] J. Pelletier,et al. IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients. , 1996, Osteoarthritis and cartilage.
[33] J. Pelletier,et al. Prostaglandin E2 stimulates incorporation of proline into collagenase digestible proteins in human articular chondrocytes: identification of an effector autocrine loop involving insulin-like growth factor I , 1996, Molecular and Cellular Endocrinology.
[34] R. Considine,et al. Gender differences in serum leptin levels in humans. , 1996, Biochemical and molecular medicine.
[35] R. Seeley,et al. Identification of targets of leptin action in rat hypothalamus. , 1996, The Journal of clinical investigation.
[36] J. Darnell,et al. Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice , 1996, Nature Genetics.
[37] L. Tartaglia,et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[38] O. Johnell,et al. Effect of transforming growth factor‐β and platelet‐derived growth factor‐BB on articular cartilage in rats , 1996, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[39] T. Spector,et al. The association of obesity with osteoarthritis of the hand and knee in women: a twin study. , 1996, The Journal of rheumatology.
[40] R. Skoda,et al. Defective STAT signaling by the leptin receptor in diabetic mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[41] E. Märker-Hermann,et al. Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and seronegative spondylarthropathies. , 1996, Clinical and experimental rheumatology.
[42] J. Tyler,et al. Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1 beta (IL-1 beta), and IL-6 mRNA expression in osteoarthritic and normal human cartilage. , 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[43] C. Westacott,et al. Cytokines in osteoarthritis: mediators or markers of joint destruction? , 1996, Seminars in arthritis and rheumatism.
[44] Rene Devos,et al. Identification and expression cloning of a leptin receptor, OB-R , 1995, Cell.
[45] T. Aigner,et al. Differential expression of collagen types I, II, III, and X in human osteophytes. , 1995, Laboratory investigation; a journal of technical methods and pathology.
[46] M. Pelleymounter,et al. Effects of the obese gene product on body weight regulation in ob/ob mice. , 1995, Science.
[47] R. Devos,et al. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. , 1995, Science.
[48] Steven L. Cohen,et al. Weight-reducing effects of the plasma protein encoded by the obese gene. , 1995, Science.
[49] K. Nakao,et al. Human Obese Gene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue , 1995, Diabetes.
[50] J. Beresford,et al. Osteoblasts and osteoclasts in adult human osteophyte tissue express the mRNAs for insulin-like growth factors I and II and the type 1 IGF receptor. , 1995, Bone.
[51] M. Maffei,et al. Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.
[52] W. B. van den Berg,et al. In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences. , 1994, Annals of the rheumatic diseases.
[53] W. B. van den Berg,et al. Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. , 1994, Laboratory investigation; a journal of technical methods and pathology.
[54] S. Yamashita,et al. Effects of interleukin-1 beta on insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes. , 1994, Annals of the rheumatic diseases.
[55] J. Pelletier,et al. The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function. , 1992, Arthritis and rheumatism.
[56] F. Luyten,et al. Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants. , 1988, Archives of biochemistry and biophysics.
[57] R. Moskowitz,et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. , 1986, Arthritis and rheumatism.
[58] H. Muir,et al. In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis. , 1984, Arthritis and rheumatism.
[59] H. Dorfman,et al. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. , 1971, The Journal of bone and joint surgery. American volume.
[60] H J Mankin,et al. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. , 1970, The Journal of bone and joint surgery. American volume.
[61] Ash Je. Howard Thomas Karsner. , 1958 .
[62] C. Drevon,et al. Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling , 2002, Journal of cellular biochemistry.
[63] W. B. van den Berg,et al. Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections. , 2000, Osteoarthritis and cartilage.
[64] M. Goldring. The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. , 1999, Connective tissue research.
[65] G. Fantuzzi,et al. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. , 1999, American journal of physiology. Regulatory, integrative and comparative physiology.
[66] M. Donowitz,et al. Squalamine, a novel cationic steroid, specifically inhibits the brush-border Na+/H+exchanger isoform NHE3. , 1999, American journal of physiology. Cell physiology.