Lipid Peroxide Levels in the Skin of the Senescence-Accelerated Mouse

Lipid peroxide levels in the skin of the senescence-accelerated mouse (SAM) were examined in relation to the appearance of symptoms in the skin. In SAM-P/1 mice (accelerated senescence-prone mice), symptoms such as a decrease in hair glossiness and skin ulcers begin to be observable at 5-6 months of age, mainly in the skin of dorsal neck. Prior to the appearance of the skin symptoms, the lipid peroxide level in this region of the skin of SAM-P/1 mice was significantly higher than that of the corresponding region of SAM-R/1 mice (accelerated senescence-resistant mice). Lipid peroxide levels in the skin of dorsal neck tended to be in parallel with those in the serum in SAM-P/1 mice of 3-4 months of age. These results suggest that in SAM-P/1 mice lipid peroxides increased in the blood are transferred to the skin where they provoke degeneration of the cells followed by the appearance of skin lesions.

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