STUDIES ON AN INTERMITTENT CORTICOSTEROID DOSAGE REGIMEN.

CORTISOL and its derivatives are effective and necessary in the management of some patients with certain diseases, but their prolonged use may be associated with undesirable side effects ranging from minor and annoying ones to life-threatening reactions. The incidence of undesirable side effects varies from series to series, but the general consensus is that these effects are related to dosage and duration of therapy. Livingstone and Davies1 have reviewed their experience with steroids in asthma, which parallels in general our own previous experience. Since the therapeutic effects of steroids appeared to us to persist longer than their metabolic effects, it . . .

[1]  I. F. Duff,et al.  The association of cataract formation and systemic corticosteroid therapy. , 1962, JAMA.

[2]  R. Thiers,et al.  Interference-free flame photometry of calcium in serum and urine. , 1962, Clinical chemistry.

[3]  J. J. Bunim,et al.  Cataracts in rheumatoid arthritis patients treated with corticosteroids. Description and differential diagnosis. , 1961, Archives of ophthalmology.

[4]  J. Davies,et al.  Steroids in the long-term treatment of asthma. , 1961, Lancet.

[5]  W. Sauer,et al.  Withdrawal of adrenal steroids and corticotropin. Clinical observations in chronic ulcerative colitis. , 1961, Archives of internal medicine.

[6]  J. J. Bunim,et al.  Posterior subcapsular cataracts induced by corticosteroids in patients with rheumatoid arthritis. , 1960, JAMA.

[7]  D. Mitchell,et al.  Clinical, metabolic and endocrinologic effects of abrupt cessation of maintenance cortisone acetate therapy in rheumatoid arthritis. , 1960, Arthritis and rheumatism.

[8]  T. A. Good,et al.  Symptomatology resulting from withdrawal of steroid hormone therapy. , 1959, Arthritis and rheumatism.

[9]  E. Froesch,et al.  Specific Enzymatic Determination of Glucose in Blood and Urine Using Glucose Oxidase , 1956, Diabetes.

[10]  A. Renold,et al.  Highly potent adrenal cortical steroids: structure and biologic activity. , 1955, Annals of Internal Medicine.

[11]  J. J. Bunim,et al.  METABOLIC EFFECTS OF METACORTANDRALONE AND METACORTANDRACIN , 1955, Annals of the New York Academy of Sciences.

[12]  Reddy Wj.  Modification of the Reddy-Jenkins-Thorn method for the estimation of 17-hydroxycorticoids in urine. , 1954 .

[13]  A. Renold,et al.  The use of intravenous ACTH: a study in quantitative adrenocortical stimulation. , 1952, The Journal of clinical endocrinology and metabolism.

[14]  T. H. Mcgavack,et al.  The determination of urinary steroids. I. The preparation of pigment-free extracts and a simplified procedure for the estimation of total 17-ketosteroids. , 1952, The Journal of clinical endocrinology and metabolism.

[15]  T. Mcmeekin,et al.  A NEW DIRECT NESSLERIZATION MICRO-KJELDAHL METHOD AND A MODIFICATION OF THE NESSLER-FOLIN REAGENT FOR AMMONIA , 1924 .