Gap Junction Dynamics Induces Localized Conductance Bistability in Cardiac Tissue

Connexins are specialized ionic channels that control the action potential propagation between cardiac myocytes. In this paper, we study the connexin dynamics in a one-dimensional model of cardiac ...

[1]  I. Imanaga.  Pathological remodeling of cardiac gap junction connexin 43-With special reference to arrhythmogenesis. , 2010, Pathophysiology : the official journal of the International Society for Pathophysiology.

[2]  P. Ferdinandy,et al.  Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection. , 2015, Pharmacology & therapeutics.

[3]  S. Verheule,et al.  Connexin diversity in the heart: insights from transgenic mouse models , 2013, Front. Pharmacol..

[4]  Angelina Peñaranda,et al.  Phase-2 reentry in cardiac tissue: role of the slow calcium pulse. , 2010, Physical review. E, Statistical, nonlinear, and soft matter physics.

[5]  Trine Krogh-Madsen,et al.  Introduction to Focus Issue: Complex Cardiac Dynamics. , 2017, Chaos.

[6]  W. G. Ye,et al.  Junctional delay, frequency, and direction-dependent uncoupling of human heterotypic Cx45/Cx43 gap junction channels. , 2017, Journal of molecular and cellular cardiology.

[7]  M. J. Bunner,et al.  Identification of continuous, spatiotemporal systems. , 1998 .

[8]  Claudia Hawks,et al.  Influence of gap junction dynamics on the stability of reentrant waves in cardiac tissue , 2015, 2015 Computing in Cardiology Conference (CinC).

[9]  J E Saffitz,et al.  Dephosphorylation and Intracellular Redistribution of Ventricular Connexin43 During Electrical Uncoupling Induced by Ischemia , 2000, Circulation research.

[10]  T. Desplantez,et al.  Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties , 2004, Pflügers Archiv.

[11]  Tanmay A. Gokhale,et al.  Modeling dynamics in diseased cardiac tissue: Impact of model choice. , 2017, Chaos.

[12]  R Vogel,et al.  Mathematical model of vertebrate gap junctions derived from electrical measurements on homotypic and heterotypic channels , 1998, The Journal of physiology.

[13]  A. Santos-Miranda,et al.  Effects of temperature on transjunctional voltage-dependent gating kinetics in Cx45 and Cx40 gap junction channels. , 2019, Journal of molecular and cellular cardiology.

[14]  N. Peters,et al.  Myocardial architecture and ventricular arrhythmogenesis. , 1998, Circulation.

[15]  B. Larsen,et al.  Gap junction modifier rotigaptide decreases the susceptibility to ventricular arrhythmia by enhancing conduction velocity and suppressing discordant alternans during therapeutic hypothermia in isolated rabbit hearts. , 2016, Heart rhythm.

[16]  Nader Moazami,et al.  Conduction Remodeling in Human End-Stage Nonischemic Left Ventricular Cardiomyopathy , 2012, Circulation.

[17]  Z. Qu.  Network Dynamics in Cardiac Electrophysiology , 2014 .

[18]  Natalia A. Trayanova,et al.  Advances in Modeling Cardiac Defibrillation , 2003, Int. J. Bifurc. Chaos.

[19]  E. Hertzberg,et al.  Gap junctions: New tools, new answers, new questions , 1991, Neuron.

[20]  Frank B. Sachse,et al.  Electrophysiological Modeling of Fibroblasts and their Interaction with Myocytes , 2007, Annals of Biomedical Engineering.

[21]  Mario Delmar,et al.  Cardiac connexins, mutations and arrhythmias , 2012, Current opinion in cardiology.

[22]  Y Rudy,et al.  Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. , 1997, Circulation research.

[23]  Gary Tse,et al.  Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions , 2015, International journal of cardiology. Heart & vasculature.

[24]  P. Lampe,et al.  Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size , 2014, Journal of Cell Science.

[25]  D. Noble,et al.  A model for human ventricular tissue. , 2004, American journal of physiology. Heart and circulatory physiology.

[26]  Jürgen Kurths,et al.  Nonlinear Analysis of Physiological Data , 2011 .

[27]  J. Saffitz,et al.  Gap junctions and arrhythmogenic cardiomyopathy. , 2012, Heart rhythm.

[28]  Emmanuel Dupont,et al.  Gap Junction Channels and Cardiac Impulse Propagation , 2007, Journal of Membrane Biology.

[29]  J. Keener,et al.  The effects of discrete gap junction coupling on propagation in myocardium. , 1991, Journal of theoretical biology.

[30]  R C Barr,et al.  Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth. , 2000, Circulation research.

[31]  Murad Banaji,et al.  Monotone dynamics of two cells dynamically coupled by a voltage-dependent gap junction. , 2009, Journal of theoretical biology.

[32]  B. Griffith,et al.  Adaptive multiscale model for simulating cardiac conduction , 2010, Proceedings of the National Academy of Sciences.

[33]  M. Bennett,et al.  Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: Properties of fast and slow gating mechanisms , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[34]  R. Veenstra,et al.  Regulation of Connexin43 Gap Junctional Conductance by Ventricular Action Potentials , 2003, Circulation research.

[35]  J Jalife,et al.  Connexins and Impulse Propagation in the Mouse Heart , 1999, Journal of cardiovascular electrophysiology.

[36]  Honghong Chen,et al.  Functional Characterization of Novel Atrial Fibrillation-Linked GJA5 (Cx40) Mutants , 2018, International journal of molecular sciences.

[37]  Sawa Kostin,et al.  Gap junction remodeling and altered connexin43 expression in the failing human heart , 2004, Molecular and Cellular Biochemistry.

[38]  N. Severs,et al.  Gap junctions; , 2008 .

[39]  D. Bers,et al.  A novel computational model of the human ventricular action potential and Ca transient. , 2010, Journal of Molecular and Cellular Cardiology.

[40]  D. Tester,et al.  Connexin43 Mutation Causes Heterogeneous Gap Junction Loss and Sudden Infant Death , 2012, Circulation.

[41]  G. Fishman,et al.  Heterogeneous Expression of Gap Junction Channels in the Heart Leads to Conduction Defects and Ventricular Dysfunction , 2001, Circulation.

[42]  F. Fenton,et al.  Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation. , 1998, Chaos.

[43]  K. Boengler,et al.  Connexins in cardiac ischemia , 2018 .