Imaging of Congenital Malformations of Brain: A Pictorial Essay

“A sad end to a happy dream” is what a newborn child with congenital brain anomalies can be to the parents. Nevertheless, diagnosing it correctly is of paramount importance. Imaging plays an important role in reaching the correct diagnosis. It is as important for every pediatrician to be familiar with basic imaging findings of common congenital anomalies, as it is for the radiologist. This pictorial essay attempts to concisely present the imaging features of common congenital anomalies. In this article we will first present a simplified classification of congenital anomalies affecting brain, followed by images and imaging findings of the common and certain uncommon but interesting or important congenital anomalies. Congenital anomalies can be broadly categorized into hindbrain herniations and miscellaneous malformations, hindbrain malformations (Posterior fossa malformations and cysts), disorders of diverticulation and cleavage and malformations of cortical development. In postnatal period, usually CT is the initial diagnostic tool. But MRI is superior to CT in most of the cases.

[1]  P. Steinbok Clinical features of Chiari I malformations , 2004, Child's Nervous System.

[2]  C. L. Campbell Septo-optic dysplasia: a literature review. , 2003, Optometry.

[3]  A. Arjona,et al.  Septo-optic dysplasia plus , 2003, The Lancet Neurology.

[4]  A James Barkovich,et al.  Analysis and classification of cerebellar malformations. , 2002, AJNR. American journal of neuroradiology.

[5]  N. Kocer,et al.  Rhombencephalosynapsis: clinical findings and neuroimaging in 9 children. , 2002, Neuropediatrics.

[6]  L. Flores‐Sarnat Hemimegalencephaly: part 1. Genetic, clinical, and imaging aspects. , 2002 .

[7]  A J Barkovich,et al.  Gray matter heterotopia. , 2000, Neurology.

[8]  A. Barkovich,et al.  Magnetic Resonance Imaging Features and Classification of Central Nervous System Malformations in Joubert Syndrome , 1999, Journal of child neurology.

[9]  F. Andermann,et al.  Familial Agenesis of the Cerebellar Vermis: A Syndrome of Episodic Hyperpnea, Abnormal Eye Movements, Ataxia, and Retardation , 1999, Neurology.

[10]  B. Maria,et al.  Molar Tooth Sign in Joubert Syndrome: Clinical, Radiologic, and Pathologic Significance , 1999, Journal of child neurology.

[11]  T. Fukushima,et al.  Rhombencephalosynapsis: cerebellar embryogenesis. , 1998, AJNR. American journal of neuroradiology.

[12]  A. Barkovich,et al.  Holoprosencephaly: an analysis of callosal formation and its relation to development of the interhemispheric fissure. , 1995, AJNR. American journal of neuroradiology.

[13]  D. Norman,et al.  Revised classification of posterior fossa cysts and cystlike malformations based on the results of multiplanar MR imaging. , 1989, AJR. American journal of roentgenology.

[14]  D. Norman,et al.  Septo-optic dysplasia: MR imaging. , 1989 .

[15]  M. Thelen,et al.  MR imaging in Aicardi syndrome. , 1988, AJNR. American journal of neuroradiology.

[16]  A J Barkovich,et al.  Anomalies of the corpus callosum: correlation with further anomalies of the brain. , 1988, AJR. American journal of roentgenology.

[17]  G. Ponsot,et al.  Hemimegalencephaly: MR imaging in five children. , 1987, Radiology.

[18]  N. Altman,et al.  Holoprosencephaly classified by computed tomography. , 1984, AJNR. American journal of neuroradiology.

[19]  T. Naidich,et al.  Computed tomographic signs of Chiari II malformation. II: Midbrain and cerebellum. , 1980, Radiology.

[20]  T. Hayashi,et al.  Radiological features of holoprosencephaly. , 1979, Surgical neurology.

[21]  S. Viana,et al.  Rhombencephalosynapsis: CT and MRI findings. , 2004, Neurology India.

[22]  T. Naidich,et al.  The Chiari II malformation: Part IV. The hindbrain deformity , 2004, Neuroradiology.

[23]  A J Barkovich,et al.  Neuroimaging of focal malformations of cortical development. , 1996, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[24]  M. Castillo,et al.  Chiari III malformation: imaging features. , 1992, AJNR. American journal of neuroradiology.