Novel covalent CDK7 inhibitor potently induces apoptosis in acute myeloid leukemia and synergizes with Venetoclax
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S. Gupta | A. Dutt | M. Konopleva | Qi Zhang | P. Tembhare | S. Hasan | N. Patkar | B. Bagal | N. Khattry | L. Khare | T. Gaur | Sonal Rashmi | Ramulu Poddutoori | S. Samajdar | Murali Ramchandra | D. Shetty | Subramanian Pg | Uwe Platzbeckar | Sunil Gupta
[1] A. Wei,et al. Contemporary Approach to Acute Myeloid Leukemia Therapy in 2022. , 2022, American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting.
[2] A. Letai,et al. Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia , 2022, Signal Transduction and Targeted Therapy.
[3] L. Newell,et al. Advances in acute myeloid leukemia , 2021, BMJ.
[4] M. Tallman,et al. Harnessing the benefits of available targeted therapies in acute myeloid leukaemia. , 2021, The Lancet. Haematology.
[5] J. McGowan-Jordan,et al. Re: International System for Human Cytogenetic or Cytogenomic Nomenclature (ISCN): Some Thoughts, by T. Liehr , 2021, Cytogenetic and Genome Research.
[6] A. Roberts,et al. BCL2 inhibitors and MCL1 inhibitors for hematological malignancies. , 2021, Blood.
[7] Tuersunayi Abudureheman,et al. CDK7 Inhibitor THZ1 Induces the Cell Apoptosis of B-Cell Acute Lymphocytic Leukemia by Perturbing Cellular Metabolism , 2021, Frontiers in Oncology.
[8] G. Chatterjee,et al. Clinical impact of panel-based error-corrected next generation sequencing versus flow cytometry to detect measurable residual disease (MRD) in acute myeloid leukemia (AML) , 2021, Leukemia.
[9] M. Konopleva,et al. Acute myeloid leukemia: current progress and future directions , 2021, Blood Cancer Journal.
[10] Ki Yun Kim,et al. G1 Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181 , 2020, Cancers.
[11] Zachary L. Maas,et al. Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription , 2020, Genes & development.
[12] P. Vyas,et al. New directions for emerging therapies in acute myeloid leukemia: the next chapter , 2020, Blood Cancer Journal.
[13] Yue Jiang,et al. Pharmacological inhibition of CDK7 by THZ1 impairs tumor growth in p53-mutated HNSCC. , 2021, Oral diseases.
[14] Dayanne M. Castro,et al. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. , 2019, Cancer cell.
[15] R. Damoiseaux,et al. A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells , 2019, Nature Communications.
[16] David A. Orlando,et al. Discovery and characterization of SY-1365, a selective, covalent inhibitor of CDK7. , 2019, Cancer research.
[17] Charles Y. Lin,et al. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. , 2019, Cell chemical biology.
[18] P. Cramer,et al. MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation , 2019, Molecular cell.
[19] Z. Estrov,et al. MYC protein expression is an important prognostic factor in acute myeloid leukemia , 2019, Leukemia & lymphoma.
[20] Charles Y. Lin,et al. Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13 , 2018, eLife.
[21] E. Olejniczak,et al. A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia. , 2018, Cancer discovery.
[22] Y. Ben-Neriah,et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models , 2018, Cell.
[23] Simak Ali,et al. ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment , 2018, Molecular Cancer Therapeutics.
[24] M. Levis,et al. Advances in targeted therapy for acute myeloid leukaemia , 2018, British journal of haematology.
[25] Marina Konopleva,et al. Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. , 2017, Cancer cell.
[26] Qi Liu,et al. The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5′ and 3′ ends of genes , 2017, Nucleic acids research.
[27] R. Mesa,et al. Combined venetoclax and alvocidib in acute myeloid leukemia , 2017, Oncotarget.
[28] Zhenfeng Zhang,et al. Preclinical Efficacy and Molecular Mechanism of Targeting CDK7-Dependent Transcriptional Addiction in Ovarian Cancer , 2017, Molecular Cancer Therapeutics.
[29] G. O'Neill,et al. Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma , 2017, Oncogenesis.
[30] A. Letai,et al. Discovery and biological characterization of potent myeloid cell leukemia‐1 inhibitors , 2017, FEBS letters.
[31] A. Strasser,et al. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models , 2016, Nature.
[32] M. Andreeff,et al. Pharmacological activation of wild-type p53 in the therapy of leukemia. , 2016, Experimental hematology.
[33] C. Tse,et al. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) , 2015, Cell Death and Disease.
[34] D. MacPherson,et al. Treating transcriptional addiction in small cell lung cancer. , 2014, Cancer cell.
[35] Bandana Sharma,et al. CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer , 2014, Cell.
[36] T. Albert,et al. Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor Cells , 2014, Molecular and Cellular Biology.
[37] Neville E. Sanjana,et al. Improved vectors and genome-wide libraries for CRISPR screening , 2014, Nature Methods.
[38] Sridhar Ramaswamy,et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor , 2014, Nature.
[39] M. Barbacid,et al. Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion , 2012, The EMBO journal.
[40] T. Chou. Drug combination studies and their synergy quantification using the Chou-Talalay method. , 2010, Cancer research.
[41] M. Cole,et al. The Myc Transactivation Domain Promotes Global Phosphorylation of the RNA Polymerase II Carboxy-Terminal Domain Independently of Direct DNA Binding , 2007, Molecular and Cellular Biology.
[42] M. Cole,et al. The Proto-oncogene c-myc Acts through the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1to Facilitate the Activation of Cdk4/6 and Early G1Phase Progression* , 2002, The Journal of Biological Chemistry.
[43] M. Mathews,et al. Three RNA Polymerase II Carboxyl-terminal Domain Kinases Display Distinct Substrate Preferences* , 2001, The Journal of Biological Chemistry.
[44] X. Chen,et al. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner , 1997, Molecular and cellular biology.
[45] Hilde van der Togt,et al. Publisher's Note , 2003, J. Netw. Comput. Appl..
[46] H. Kantarjian,et al. Acute myeloid leukemia , 2018, Methods in Molecular Biology.