NAT2 gene polymorphism as a possible marker for susceptibility to bladder cancer in Japanese

Background : N‐acetyltransferase (NAT) is known to metabolize the carcinogen arylamine. The polymorphism of the NAT2 gene is an important determinant of individual susceptibility to bladder cancer. There are significant interethnic differences in NAT2 allele frequencies. The relationship between NAT2 genotypes and bladder cancer in a Japanese population was investigated.

[1]  D. Bell,et al.  Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder. , 1995, Cancer research.

[2]  A. Risch,et al.  Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants. , 1992, Pharmacogenetics.

[3]  A. Risch,et al.  Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer. , 1995, Human molecular genetics.

[4]  D. Hein.  Acetylator genotype and arylamine-induced carcinogenesis. , 1988, Biochimica et biophysica acta.

[5]  T. Hanaoka,et al.  N‐Acetyltransferase Activity in the Urine in Japanese Subjects: Comparison in Healthy Persons and Bladder Cancer Patients , 1995, Japanese journal of cancer research : Gann.

[6]  W. Weber,et al.  Diverse point mutations in the human gene for polymorphic N-acetyltransferase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[7]  S. Mommsen,et al.  Susceptibility in urinary bladder cancer: acetyltransferase phenotypes and related risk factors. , 1986, Cancer letters.

[8]  J. Chang-Claude,et al.  Life style and occupational risk factors for bladder cancer in Germany. A case‐control study , 1992, Cancer.

[9]  D. Grant,et al.  Molecular mechanism of slow acetylation of drugs and carcinogens in humans. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[10]  M A Butler,et al.  Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis. , 1992, Environmental health perspectives.

[11]  K. Ilett,et al.  Acetylation phenotype in colorectal carcinoma. , 1987, Cancer research.

[12]  P Vineis,et al.  Proportion of lung and bladder cancers in males resulting from occupation: a systematic approach. , 1991, Archives of environmental health.

[13]  J. Brockmöller,et al.  Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. , 1996, Cancer research.

[14]  D. Grant,et al.  Genotyping of the polymorphic N-acetyltransferase (NAT2*) gene locus in two native African populations. , 1996, Pharmacogenetics.

[15]  E. Sim,et al.  N-acetyltransferase polymorphism. Comparison of phenotype and genotype in humans. , 1991, Biochemical pharmacology.

[16]  D. Hoffmann,et al.  Chemical Studies on Tobacco Smoke LXIV. On the Analysis of Aromatic Amines in Cigarette Smoke , 1979 .

[17]  R. Glashan,et al.  ROLE OF N-ACETYLTRANSFERASE PHENOTYPES IN BLADDER CARCINOGENESIS: A PHARMACOGENETIC EPIDEMIOLOGICAL APPROACH TO BLADDER CANCER , 1982, The Lancet.

[18]  S. Mommsen,et al.  N-Acetyltransferase phenotypes in the urinary bladder carcinogenesis of a low-risk population. , 1985, Carcinogenesis.

[19]  T. Deguchi,et al.  Correlation between acetylator phenotypes and genotypes of polymorphic arylamine N-acetyltransferase in human liver. , 1990, The Journal of biological chemistry.

[20]  R. Hayes,et al.  N-acetylation phenotype and genotype and risk of bladder cancer in benzidine-exposed workers. , 1993, Carcinogenesis.

[21]  B. Everitt,et al.  Statistical methods for rates and proportions , 1973 .

[22]  W. Hueper.  Experimental production of bladder tumors in dogs by administration of beta-naphthylamine. , 1938 .

[23]  L. Rehn.  Blasengeschwülste bei Fuchsin-Arbeitern , 1991 .

[24]  B. Lin,et al.  Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene. , 1994, Pharmacogenetics.

[25]  Jack A. Taylor,et al.  Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. , 1993, Carcinogenesis.

[26]  H. Okkels,et al.  Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking. , 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[27]  W. Grove.  Statistical Methods for Rates and Proportions, 2nd ed , 1981 .