Telehealthcare and Covid-19: A Noninvasive & Low Cost Invasive, Scalable and Multimodal Real-Time Smartphone Application for Early Diagnosis of SARS-CoV-2 Infection

The global coronavirus pandemic overwhelmed many health care systems, enforcing lockdown and encouraged work from home to control the spread of the virus and prevent overrunning of hospitalized patients. This prompted a sharp widespread use of telehealth to provide low-risk care for patients. Nevertheless, a continuous mutation into new variants and widespread unavailability of test kits, especially in developing countries, possess the challenge to control future potential waves of infection. In this paper, we propose a novel Smartphone application-based platform for early diagnosis of possible Covid-19 infected patients. The application provides three modes of diagnosis from possible symptoms, cough sound, and specific blood biomarkers. When a user chooses a particular setting and provides the necessary information, it sends the data to a trained machine learning (ML) model deployed in a remote server using the internet. The ML algorithm then predicts the possibility of contracting Covid-19 and sends the feedback to the user. The entire procedure takes place in real-time. Our machine learning models can identify Covid-19 patients with an accuracy of 100%, 95.65%, and 77.59% from blood parameters, cough sound, and symptoms respectively. Moreover, the ML sensitivity for blood and sound is 100%, which indicates correct identification of Covid positive patients. This is significant in limiting the spread of the virus. The multimodality offers multiplex diagnostic methods to better classify possible infectees and together with the instantaneous nature of our technique, demonstrates the power of telehealthcare as an easy and widespread low-cost scalable diagnostic solution for future pandemics.

[1]  Abdullah Bin Shams,et al.  Identification of the Resting Position Based on EGG, ECG, Respiration Rate and SpO2 Using Stacked Ensemble Learning , 2021, ArXiv.

[2]  A. Harris,et al.  Trends in the Use of Telehealth During the Emergence of the COVID-19 Pandemic — United States, January–March 2020 , 2020, MMWR. Morbidity and mortality weekly report.

[3]  Timothy F. Leslie,et al.  Complexity of the Basic Reproduction Number (R0) , 2019, Emerging infectious diseases.

[4]  Diana Patricia Tobón Vallejo,et al.  A Machine Learning Approach as an Aid for Early COVID-19 Detection , 2021, Sensors.

[5]  Jennifer Collins,et al.  Artificial Intelligence for COVID-19 Drug Discovery and Vaccine Development , 2020, Frontiers in Artificial Intelligence.

[6]  Brian Subirana,et al.  COVID-19 Artificial Intelligence Diagnosis Using Only Cough Recordings , 2020, IEEE Open Journal of Engineering in Medicine and Biology.

[7]  Molla Rashied Hussein,et al.  Web Search Engine Misinformation Notifier Extension (SEMiNExt): A Machine Learning Based Approach during COVID-19 Pandemic , 2021, Healthcare.

[8]  Srikanth Raj Chetupalli,et al.  Coswara - A Database of Breathing, Cough, and Voice Sounds for COVID-19 Diagnosis , 2020, INTERSPEECH.

[9]  Gunvant R. Chaudhari,et al.  Virufy: Global Applicability of Crowdsourced and Clinical Datasets for AI Detection of COVID-19 from Cough , 2020, ArXiv.

[10]  Abdullah Bin Shams,et al.  Development of Risk-Free COVID-19 Screening Algorithm from Routine Blood Test using Ensemble Machine Learning , 2021, ArXiv.

[11]  Pauline Mouawad,et al.  Robust Detection of COVID-19 in Cough Sounds , 2021, SN Comput. Sci..

[12]  Abdullah Bin Shams,et al.  Survival Prediction of Heart Failure Patients using Stacked Ensemble Machine Learning Algorithm , 2021, 2021 IEEE International Women in Engineering (WIE) Conference on Electrical and Computer Engineering (WIECON-ECE).

[13]  B. Far,et al.  An ensemble learning approach to digital corona virus preliminary screening from cough sounds , 2021, Scientific Reports.

[14]  T. Davenport,et al.  The potential for artificial intelligence in healthcare , 2019, Future Healthcare Journal.

[15]  S. Seneviratne,et al.  Hematological Abnormalities in COVID-19: A Narrative Review , 2021, The American journal of tropical medicine and hygiene.

[16]  Nour Atef,et al.  Detection COVID-19 using Machine Learning from Blood Tests , 2021, 2021 International Mobile, Intelligent, and Ubiquitous Computing Conference (MIUCC).

[17]  Christian Etmann,et al.  Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans , 2020 .

[18]  Alexander Wong,et al.  COVID-Net: a tailored deep convolutional neural network design for detection of COVID-19 cases from chest X-ray images , 2020, Scientific reports.

[19]  Md. Mohsin Sarker Raihan,et al.  Multi-Class Electrogastrogram (EGG) Signal Classification Using Machine Learning Algorithms , 2020, 2020 23rd International Conference on Computer and Information Technology (ICCIT).

[20]  Chest x-ray findings and temporal lung changes in patients with COVID-19 pneumonia , 2020, BMC Pulmonary Medicine.

[21]  A Comparative Study to Predict the Diabetes Risk Using Different Kernels of Support Vector Machine , 2021, 2021 2nd International Conference on Robotics, Electrical and Signal Processing Techniques (ICREST).

[22]  Gaël Varoquaux,et al.  Scikit-learn: Machine Learning in Python , 2011, J. Mach. Learn. Res..

[23]  D. Ragab,et al.  The COVID-19 Cytokine Storm; What We Know So Far , 2020, Frontiers in Immunology.

[24]  Shuyan Li,et al.  Rapid and accurate identification of COVID-19 infection through machine learning based on clinical available blood test results , 2020, medRxiv.

[25]  Mei U Wong,et al.  COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning , 2020, bioRxiv.

[26]  A. Giri,et al.  Charting the challenges behind the testing of COVID-19 in developing countries: Nepal as a case study , 2020, Biosafety and Health.

[27]  Brandon M. Welch,et al.  Patient preferences for direct-to-consumer telemedicine services: a nationwide survey , 2017, BMC Health Services Research.

[28]  Xin Zhao,et al.  Identification of COVID-19 samples from chest X-Ray images using deep learning: A comparison of transfer learning approaches , 2020, Journal of X-ray science and technology.

[29]  Theodora Psaltopoulou,et al.  Hematological findings and complications of COVID‐19 , 2020, American journal of hematology.

[30]  Zhenghao Xu,et al.  Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies , 2020, Frontiers in Immunology.

[31]  N. Shomron,et al.  Machine learning-based prediction of COVID-19 diagnosis based on symptoms , 2021, npj Digital Medicine.

[32]  Mehedi Masud,et al.  A Comparative Analysis of Machine Learning Algorithms to Predict Liver Disease , 2021, Intelligent Automation & Soft Computing.

[33]  M. Jones,et al.  The role of chest radiography in confirming covid-19 pneumonia , 2020, BMJ.