A novel CMOS lab-on-a-chip for biomedical applications

A novel CMOS integrated laboratory-on-a-chip is presented. It contains both the sensing and actuation parts in a single chip. Experimental and simulation results showed that the chip can inline process the sensing and the actuation and they can trap, concentrate, and quantify biocells. Moreover, the proposed laboratory-on-a-chip can deal with the biological systems at the cell level and it can extract real time information about the biological cells' behaviors using direct measurements.

[1]  N. Manaresi,et al.  A CMOS chip for individual cell manipulation and detection , 2003, 2003 IEEE International Solid-State Circuits Conference, 2003. Digest of Technical Papers. ISSCC..

[2]  M. Washizu,et al.  Electrostatic manipulation of DNA in microfabricated structures , 1989, Conference Record of the IEEE Industry Applications Society Annual Meeting,.

[3]  Roberto Guerrieri,et al.  A lab-on-a-chip for cell detection and manipulation , 2003 .