Progressive hemispheric atrophy in HIV: A Rasmussen's‐like variant of CD8 encephalitis?

We report two cases of progressive lateralising encephalopathy in adult patients with treated HIV in the absence of opportunistic infection or vasculitis. One case was characterised by CD8 cortical infiltrates and was steroid responsive and may represent a variant of CD8 encephalitis. The other case presented with focal seizures and episodes of status epilepticus and pathology showed severe cortical atrophy with features reminiscent of the chronic phase of Rasmussen's encephalitis.

[1]  K. Wong,et al.  HIV-Associated CD8 Encephalitis: A UK Case Series and Review of Histopathologically Confirmed Cases , 2021, Frontiers in Neurology.

[2]  L. M. Santana,et al.  CD8 + T-lymphocyte Encephalitis: A Systematic Review. , 2020, AIDS reviews.

[3]  S. Hutchinson,et al.  Possible N-methyl-D-aspartate receptor antibody-mediated encephalitis in the setting of HIV cerebrospinal fluid escape , 2020, Journal of Neurology.

[4]  H. Budka,et al.  Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis , 2017, Neurology: Neuroimmunology & Neuroinflammation.

[5]  M. Vidailhet,et al.  Late-onset Rasmussen Encephalitis: A literature appraisal. , 2017, Autoimmunity reviews.

[6]  B. Weinshenker,et al.  Glial fibrillary acidic protein immunoglobulin G as biomarker of autoimmune astrocytopathy: Analysis of 102 patients , 2017, Annals of neurology.

[7]  D. Kullmann,et al.  CD8+ encephalitis: a severe but treatable HIV-related acute encephalopathy , 2016, Practical Neurology.

[8]  E. Smolewska,et al.  Kaleidoscope of autoimmune diseases in HIV infection , 2016, Rheumatology International.

[9]  O. Lambotte,et al.  Autoimmune diseases in HIV-infected patients: 52 cases and literature review. , 2014, Autoimmunity reviews.

[10]  F. Jensen,et al.  Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances , 2014, The Lancet Neurology.

[11]  H. Adle-Biassette,et al.  Encephalitis with Infiltration by CD8+ Lymphocytes in HIV Patients Receiving Combination Antiretroviral Treatment , 2013, Brain pathology.

[12]  G. Carcelain,et al.  CD8 encephalitis in HIV-infected patients receiving cART: a treatable entity. , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[13]  E. Mohammadi,et al.  Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[14]  F. Scaravilli,et al.  Cerebral CD8+ lymphocytosis in HIV-1 infected patients with immune restoration induced by HAART , 2004, Acta Neuropathologica.

[15]  N. Yanagisawa,et al.  CD8 Encephalitis Caused by Persistently Detectable Drug-resistant HIV. , 2016, Internal medicine.