The arcuate fasciculus in auditory-verbal hallucinations: A meta-analysis of diffusion-tensor-imaging studies

Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy controls (HCs). Five studies were retained gathering 256 DTI data points, divided into AVHs (n=106) and HCs (n=150). The meta-analysis demonstrated a reduced fractional anisotropy in the left Arcuate Fasciculus (AF) of hallucinators (hg= -0.42; CI[-0.69,-0.16]; p<10(-3)). The current meta-analysis confirmed disruptions of white matter integrity in the left AF bundle of schizophrenia patients with AVHs.

[1]  K R Abrams,et al.  Bayesian methods in meta-analysis and evidence synthesis. , 2001, Statistical methods in medical research.

[2]  Jae-Jin Kim,et al.  White matter abnormalities associated with auditory hallucinations in schizophrenia: A combined study of voxel-based analyses of diffusion tensor imaging and structural magnetic resonance imaging , 2007, Psychiatry Research: Neuroimaging.

[3]  D. Moher,et al.  Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement , 2009, BMJ : British Medical Journal.

[4]  Elia Formisano,et al.  Anatomical brain connectivity and positive symptoms of schizophrenia: A diffusion tensor imaging study , 2009, Psychiatry Research: Neuroimaging.

[5]  Anqi Qiu,et al.  Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia , 2012, PloS one.

[6]  Michel Thiebaut de Schotten,et al.  Atlas of Human Brain Connections , 2012 .

[7]  M. Kubicki,et al.  Hearing voices: A role of interhemispheric auditory connectivity? , 2012, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[8]  Vincent van de Ven,et al.  Interhemispheric hypoconnectivity in schizophrenia: Fiber integrity and volume differences of the corpus callosum in patients and unaffected relatives , 2012, NeuroImage.

[9]  R. Hoffman,et al.  Functional connectivity studies of patients with auditory verbal hallucinations , 2011, Front. Hum. Neurosci..

[10]  D Mataix-Cols,et al.  Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls , 2010, Psychological Medicine.

[11]  A. Cachia,et al.  The Neuroscience of Hallucinations , 2013 .

[12]  R. S. Kahn,et al.  Microstructural alterations of the arcuate fasciculus in schizophrenia patients with frequent auditory verbal hallucinations , 2011, Schizophrenia Research.

[13]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[14]  Renaud Jardri,et al.  Cortical activations during auditory verbal hallucinations in schizophrenia: a coordinate-based meta-analysis. , 2011, The American journal of psychiatry.

[15]  Stephanie J. Forkel,et al.  Altered Integrity of Perisylvian Language Pathways in Schizophrenia: Relationship to Auditory Hallucinations , 2011, Biological Psychiatry.

[16]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement , 2009, BMJ : British Medical Journal.

[17]  Helen Brown,et al.  Applied Mixed Models in Medicine , 2000, Technometrics.

[18]  Derek K. Jones,et al.  A diffusion tensor imaging study of fasciculi in schizophrenia. , 2007, The American journal of psychiatry.

[19]  Remco Renken,et al.  Not on speaking terms: hallucinations and structural network disconnectivity in schizophrenia , 2013, Brain Structure and Function.

[20]  Paul Allen,et al.  Auditory Verbal Hallucinations and Brain Dysconnectivity in the Perisylvian Language Network: A Multimodal Investigation , 2013, Schizophrenia bulletin.

[21]  A. Cachia,et al.  The multimodal connectivity of the hippocampal complex in auditory and visual hallucinations , 2014, Molecular Psychiatry.

[22]  D. Hubl,et al.  Pathways that make voices: white matter changes in auditory hallucinations. , 2004, Archives of general psychiatry.