Hyper-vision in a patient with central and paracentral vision loss reflects cortical reorganization

SM, a 21-year-old female, presents an extensive central scotoma (30 deg) with dense absolute scotoma (visual acuity = 10/100) in the macular area (10 deg) due to Stargardt's disease. We provide behavioral evidence of cortical plastic reorganization since the patient could perform several visual tasks with her poor-vision eyes better than controls, although high spatial frequency sensitivity and visual acuity are severely impaired. Between 2.5-deg and 12-deg eccentricities, SM presented (1) normal acuity for crowded letters, provided stimulus size is above acuity thresholds for single letters; (2) a two-fold sensitivity increase (d-prime) with respect to controls in a simple search task; and (3) largely above-threshold performance in a lexical decision task carried out randomly by controls. SM's hyper-vision may reflect a long-term sensory gain specific for unimpaired low spatial-frequency mechanisms, which may result from modifications in response properties due to practice-dependent changes in excitatory/inhibitory intracortical connections.

[1]  S. Hochstein,et al.  Attentional control of early perceptual learning. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[2]  E. Peli,et al.  Copyright © Association for Research in Vision and Ophthalmology Image Enhancement for the Visually Impaired Simulations and Experimental Results , 2022 .

[3]  Michael B. Calford,et al.  Dynamic representational plasticity in sensory cortex , 2002, Neuroscience.

[4]  M. Pettet,et al.  Dynamic changes in receptive-field size in cat primary visual cortex. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[5]  I. Ohzawa,et al.  Receptive field structure in the visual cortex: does selective stimulation induce plasticity? , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[6]  J. Sunness,et al.  IMPROVEMENT OF VISUAL ACUITY OVER TIME IN PATIENTS WITH BILATERAL GEOGRAPHIC ATROPHY FROM AGE‐RELATED MACULAR DEGENERATION , 2000, Retina.

[7]  D. Heeger,et al.  Center-surround interactions in foveal and peripheral vision , 2000, Vision Research.

[8]  Gianluca Campana,et al.  Learning in combined-feature search: Specificity to orientation , 2003, Perception & psychophysics.

[9]  S. Whittaker,et al.  Scanning characters and reading with a central scotoma. , 1985, American journal of optometry and physiological optics.

[10]  A. Jacobs,et al.  Perception of lowercase letters in peripheral vision: A discrimination matrix based on saccade latencies , 1989, Perception & psychophysics.

[11]  G. Campana,et al.  Stimulus-specific dynamics of learning in conjunction search tasks , 2001 .

[12]  J A Marshall,et al.  Models of receptive-field dynamics in visual cortex , 1999, Visual Neuroscience.

[13]  J. Palmer.  Set-size effects in visual search: The effect of attention is independent of the stimulus for simple tasks , 1994, Vision Research.

[14]  Gordon E. Legge,et al.  Psychophysics of reading—II. Low vision , 1985, Vision Research.

[15]  M Mackeben,et al.  The importance of sustained attention for patients with maculopathies , 2000, Vision Research.

[16]  S. Hochstein,et al.  Task difficulty and the specificity of perceptual learning , 1997, Nature.

[17]  A. Safran,et al.  The “thin man” phenomenon: a sign of cortical plasticity following inferior homonymous paracentral scotomas , 1999, The British journal of ophthalmology.

[18]  J. Kaas,et al.  Rapid reorganization of cortical maps in adult cats following restricted deafferentation in retina , 1992, Vision Research.

[19]  S. Hochstein,et al.  Learning Pop-out Detection: Specificities to Stimulus Characteristics , 1996, Vision Research.

[20]  D Sagi,et al.  Where practice makes perfect in texture discrimination: evidence for primary visual cortex plasticity. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[21]  A. Karni,et al.  The time course of learning a visual skill , 1993, Nature.

[22]  T Landis,et al.  Plasticity in the adult visual cortex: implications for the diagnosis of visual field defects and visual rehabilitation , 1996, Current opinion in ophthalmology.

[23]  R. L. Gregory,et al.  Perceptual filling in of artificially induced scotomas in human vision , 1991, Nature.

[24]  C. Gilbert,et al.  Topographic reorganization in the striate cortex of the adult cat and monkey is cortically mediated , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[25]  Miguel A. Andrade-Navarro,et al.  Simulation of plasticity in the adult visual cortex , 2001, Biological Cybernetics.

[26]  G Westheimer,et al.  A quantitative measure for short-term cortical plasticity in human vision , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[27]  Peter De Weerd,et al.  Responses of cells in monkey visual cortex during perceptual filling-in of an artificial scotoma , 1995, Nature.

[28]  Hyperexcitatory activity in visual cortex in homonymous hemianopia after stroke , 2001, Clinical Neurophysiology.

[29]  G. Schweigart,et al.  Spatio–temporal plasticity of cortical receptive fields in response to repetitive visual stimulation in the adult cat , 2002, Neuroscience.

[30]  W. Burke,et al.  Cortical plasticity revealed by circumscribed retinal lesions or artificial scotomas. , 2001, Progress in brain research.

[31]  J. Lipton,et al.  SUBRETINAL ABSCESS DUE TO NOCARDIA FARCINICA INFECTION , 2000, Retina.

[32]  A. Bradley.  Noninvasive assessment of the visual system , 1991 .

[33]  S. Mitra,et al.  Spatial contrast sensitivity in macular disorder , 1985, Documenta Ophthalmologica.

[34]  D. Levi,et al.  Perceptual learning in parafoveal vision , 1995, Vision Research.

[35]  M. Morgan,et al.  Visual Search for a Tilted Target: Tests of Spatial Uncertainty Models , 1998, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[36]  W. Burke,et al.  Psychophysical observations concerned with a foveal lesion (macular hole) , 1999, Vision Research.

[37]  Ra Schuchard,et al.  Preferred retinal locus. A review with applications in low vision rehabilitation , 1994 .

[38]  George L. Gerstein,et al.  Simulation of dynamic receptive fields in primary visual cortex , 1994, Vision Research.

[39]  P. Maquet,et al.  Neural correlates of perceptual learning: A functional MRI study of visual texture discrimination , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[40]  J. Marshall,et al.  Rearrangement of receptive field topography after intracortical and peripheral stimulation: the role of plasticity in inhibitory pathways , 2002, Network.