Post‐transfusion purpura responding to high dose intravenous IgG: further observations on pathogenesis

Summary. A typical case of post‐transfusion purpura (PTP) is described in a 61‐year‐old woman. Treatment with steroids corrected the purpuric manifestations, but the patient remained thrombocytopenic in spite of steroid therapy and plasma exchange. However, an intravenous infusion of high dose IgG led to a rapid and sustained increase in the platelet count.

[1]  G. Holm,et al.  High dose intravenous IgG reduces platelet associated immunoglobulins and complement in idiopathic thrombocytopenic purpura. , 2009, Scandinavian journal of haematology.

[2]  N. Grunnet,et al.  High-Dose Intravenous Immunoglobulin for Post-Transfusion Purpura , 2009 .

[3]  A. Svejgaard,et al.  HLA antigens and maternal antibodies in allo-immune neonatal thrombocytopenia. , 2008, Tissue antigens.

[4]  C. Cunningham-Rundles,et al.  Intravenous gammaglobulin treatment of chronic idiopathic thrombocytopenic purpura , 1983 .

[5]  A. Newland,et al.  HIGH-DOSE INTRAVENOUS IgG IN ADULTS WITH AUTOIMMUNE THROMBOCYTOPENIA , 1983, The Lancet.

[6]  R. Brearley,et al.  High-dose intravenous IgG in adults with autoimmune thrombocytopenia. , 1983, Lancet.

[7]  C. Engelfriet,et al.  Post‐transfusion Purpura: a Serological and Immunochemical Study , 1981, British journal of haematology.

[8]  A. Hirt,et al.  HIGH-DOSE INTRAVENOUS GAMMAGLOBULIN FOR IDIOPATHIC THROMBOCYTOPENIC PURPURA IN CHILDHOOD , 1981, The Lancet.

[9]  N. Gengozian,et al.  IgG+ platelets in the marmoset: their induction, maintenance, and survival. , 1980, Blood.

[10]  V. Grann,et al.  Posttransfusion purpura. Case report with observation on antibody detection and therapy. , 1978, Archives of internal medicine.

[11]  F. Oosterhof,et al.  A Simple Immunofluorescence Test for the Detection of Platelet Antibodies , 1978, British journal of haematology.

[12]  K. Mittal Standardization of the HLA Typing Method and Reagents , 1978, Vox sanguinis.

[13]  W. Jenkins,et al.  Post-transfusion purpura associated with unusual platelet antibody (anti-Pl-B1). , 1975, British medical journal.

[14]  R. Aster,et al.  Post-transfusion purpura: immunologic aspects and therapy. , 1974, The New England journal of medicine.

[15]  R. Aster,et al.  Post-transfusion purpura: successful treatment by exchange transfusion. , 1972, The New England journal of medicine.

[16]  R. Aster,et al.  IMMUNOREACTIONS INVOLVING PLATELETS. V. POST-TRANSFUSION PURPURA DUE TO A COMPLEMENT-FIXING ANTIBODY AGAINST A GENETICALLY CONTROLLED PLATELET ANTIGEN. A PROPOSED MECHANISM FOR THROMBOCYTOPENIA AND ITS RELEVANCE IN "AUTOIMMUNITY". , 1961, The Journal of clinical investigation.

[17]  F. Schreuder,et al.  Serological and Genetical Studies on a Platelet Antigen (Zw) , 1959, Vox sanguinis.