25(OH)D Concentration in Neonates, Infants, Toddlers, Older Children and Teenagers from Poland—Evaluation of Trends during Years 2014–2019

Introduction: Local and international guidelines have provided schedules for the vitamin D supplementation of general populations of different ages, including children. Our study aimed to assess 25(OH)D concentration and its potential change during a growth and maturation period, adding parameters that reflect the risk of hypercalcemia. Materials and methods: The available 25(OH)D concentration values (n = 17,636; 7.8 ± 6.0 years), calcium (n = 2673; 16.3 ± 6.1 years) and phosphate (n = 2830; 3.8 ± 5.2 years) metabolism markers were analyzed in a studied group of patients (0–18 years). Results: In the studied group the mean 25(OH)D concentration was 29.4 ± 11.7 ng/mL. Concentrations of 25(OH)D < 10 ng/mL were observed in 1.7% of patients (n = 292), 10–20 ng/mL in 17.2% (n = 3039), 20–30 ng/mL in 39.5% (n = 6960) and 30–50 ng/mL in 37.2% (n = 6567). In patients with a 25(OH)D concentration <10 ng/mL, normal calcemia (2.25–2.65 mmol/L) was observed in 29.5% of cases (n = 86). Three patients had 25(OH)D concentrations above 100 ng/mL with co-existing hypercalcemia; the mean was Ca = 3.40 mmol/L. Hypocalcemia (Ca < 2.25 mmol/L) was observed in 10,4% of patients (n = 2797). Furthermore, 5.0% of patients showed an increased calcium concentration >2.65 mmol/L (n = 1327). The highest mean 25(OH)D concentration of 32.1 ng/mL ± 12.9 was noted in the years 2018–2019 (n = 3931) and the lowest in the year 2015 (27.2 ng/mL ± 11.0; n = 2822). Conclusions: Vitamin D deficiency (<20 ng/mL) was noted in 18,9% of subjects in the years 2014–2019. An effective prevention of vitamin D deficiency was observed in children aged 3 years and younger. A relationship between the concentrations of calcium and 25(OH)D was not observed.

[1]  D. Zozulinska-Ziolkiewicz,et al.  Guidelines for Preventing and Treating Vitamin D Deficiency: A 2023 Update in Poland , 2023, Nutrients.

[2]  P. Płudowski,et al.  25(OH)D Concentration in Neonates, Infants, and Toddlers From Poland—Evaluation of Trends During Years 1981–2011 , 2018, Front. Endocrinol..

[3]  N. Bartolomeo,et al.  Low 25 Hydroxyvitamin D Levels are Independently Associated with Autoimmune Thyroiditis in a Cohort of Apparently Healthy Overweight and Obese Subjects. , 2018, Endocrine, metabolic & immune disorders drug targets.

[4]  M. Hiligsmann,et al.  Rationale and Plan for Vitamin D Food Fortification: A Review and Guidance Paper , 2018, Front. Endocrinol..

[5]  W. Willett,et al.  Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts , 2018, Journal of the National Cancer Institute.

[6]  A. Zittermann.  Vitamin D Status, Supplementation and Cardiovascular Disease. , 2018, Anticancer research.

[7]  Vladyslav Povoroznyuk,et al.  Vitamin D supplementation guidelines , 2018, The Journal of Steroid Biochemistry and Molecular Biology.

[8]  M. Matucci Cerinic,et al.  Cross-Sectional Evaluation of Plasma Vitamin D Levels in a Large Cohort of Italian Patients with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. , 2017, Journal of child and adolescent psychopharmacology.

[9]  B. Nordestgaard,et al.  Vitamin D, Hypertension, and Ischemic Stroke in 116 655 Individuals From the General Population: A Genetic Study , 2017, Hypertension.

[10]  P. Płudowski,et al.  Vitamin D status in Poland. , 2016, Polskie Archiwum Medycyny Wewnetrznej.

[11]  P. Płudowski,et al.  Nutritional rickets in immigrant and refugee children , 2016, Public Health Reviews.

[12]  H. van Loveren,et al.  Dietary reference values for vitamin K , 2016, EFSA journal. European Food Safety Authority.

[13]  R. Heaney,et al.  Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study , 2016, PloS one.

[14]  M. Szalecki,et al.  Vitamin D status, body composition and glycemic control in Polish adolescents with type 1 diabetes. , 2016, Minerva endocrinologica.

[15]  W. Grant.  Roles of Solar UVB and Vitamin D in Reducing Cancer Risk and Increasing Survival. , 2016, Anticancer research.

[16]  C. Mølgaard,et al.  Vitamin D deficiency in Europe: pandemic?12 , 2016, The American journal of clinical nutrition.

[17]  B. Marks,et al.  Idiopathic infantile hypercalcemia: case report and review of the literature , 2016, Journal of pediatric endocrinology & metabolism : JPEM.

[18]  M. Konrad,et al.  Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia. , 2016, Journal of the American Society of Nephrology : JASN.

[19]  O. Mäkitie,et al.  Global Consensus Recommendations on Prevention and Management of Nutritional Rickets , 2016, Hormone Research in Paediatrics.

[20]  M. Holick.  Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an Up-to-Date Perspective. , 2015, Mayo Clinic proceedings.

[21]  T. Laitinen,et al.  Childhood 25-OH vitamin D levels and carotid intima-media thickness in adulthood: the cardiovascular risk in young Finns study. , 2015, The Journal of clinical endocrinology and metabolism.

[22]  W. Grant.  25-hydroxyvitamin D and breast cancer, colorectal cancer, and colorectal adenomas: case-control versus nested case-control studies. , 2015, Anticancer research.

[23]  M. Litwin,et al.  Vitamin D status, body composition and hypertensive target organ damage in primary hypertension , 2014, The Journal of Steroid Biochemistry and Molecular Biology.

[24]  J. Buttriss,et al.  Vitamin D: An overview of vitamin D status and intake in Europe , 2014, Nutrition bulletin.

[25]  C. Palacios,et al.  Is vitamin D deficiency a major global public health problem? , 2014, The Journal of Steroid Biochemistry and Molecular Biology.

[26]  W. Grant,et al.  Vitamin D Status in Central Europe , 2014, International journal of endocrinology.

[27]  M. Holick,et al.  Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe - recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. , 2013, Endokrynologia Polska.

[28]  E. Mallet,et al.  Lightwood syndrome revisited with a novel mutation in CYP24 and vitamin D supplement recommendations. , 2013, The Journal of pediatrics.

[29]  G. Ebers,et al.  Review: The role of vitamin D in nervous system health and disease , 2013, Neuropathology and applied neurobiology.

[30]  M. Holick,et al.  Vitamin D for health: a global perspective. , 2013, Mayo Clinic proceedings.

[31]  William A Gahl,et al.  1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis. , 2013, Clinical journal of the American Society of Nephrology : CJASN.

[32]  J. Manson,et al.  Circulating 25-Hydroxy-Vitamin D and Risk of Cardiovascular Disease: A Meta-Analysis of Prospective Studies , 2012, Circulation. Cardiovascular quality and outcomes.

[33]  Bonn.  New Reference Values for Vitamin D , 2012, Annals of Nutrition and Metabolism.

[34]  Dawn S Milliner,et al.  Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy. , 2012, The Journal of clinical endocrinology and metabolism.

[35]  M. Konrad,et al.  Mutations in CYP24A1 and idiopathic infantile hypercalcemia. , 2011, The New England journal of medicine.

[36]  P. Lips,et al.  Worldwide vitamin D status. , 2011, Best practice & research. Clinical endocrinology & metabolism.

[37]  J. Mitri,et al.  Vitamin D and type 2 diabetes: a systematic review , 2011, European Journal of Clinical Nutrition.

[38]  P. Socha,et al.  Vitamin D Supplementation and Status in Infants: A Prospective Cohort Observational Study , 2011, Journal of pediatric gastroenterology and nutrition.

[39]  C. Gordon,et al.  Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. , 2011, The Journal of clinical endocrinology and metabolism.

[40]  R. Heaney,et al.  Why the IOM recommendations for vitamin D are deficient , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[41]  R. Heaney,et al.  Vitamin D supplement doses and serum 25-hydroxyvitamin D in the range associated with cancer prevention. , 2011, Anticancer research.

[42]  JoAnn E. Manson,et al.  The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know , 2010, The Journal of clinical endocrinology and metabolism.

[43]  S. Boonen,et al.  IOF position statement: vitamin D recommendations for older adults , 2010, Osteoporosis International.

[44]  T. Trikalinos,et al.  Systematic Review: Vitamin D and Cardiometabolic Outcomes , 2010, Annals of Internal Medicine.

[45]  B. Pober.  Williams-Beuren syndrome. , 2010, The New England journal of medicine.

[46]  U. Majewska,et al.  Vitamin D status in premature infants at term , 2009 .

[47]  K. Jones,et al.  Williams syndrome: an historical perspective of its evolution, natural history, and etiology. , 2005 .

[48]  D. Chant,et al.  Long-term trends in sunshine duration and its association with schizophrenia birth rates and age at first registration — data from Australia and the Netherlands , 2002, Schizophrenia Research.

[49]  H. Pols,et al.  Vitamin D , 1928, Calcified Tissue International.

[50]  R. Bouillon.  Extra-Skeletal Effects of Vitamin D. , 2018, Frontiers of hormone research.

[51]  N. Napoli,et al.  Vitamin D and Diabetes Mellitus. , 2018, Frontiers of hormone research.

[52]  Y. Frishberg,et al.  Maternal and infantile hypercalcemia caused by vitamin-D-hydroxylase mutations and vitamin D intake , 2014, Pediatric Nephrology.

[53]  R. Herr,et al.  A systematic review of vitamin D status in populations worldwide , 2013, British Journal of Nutrition.

[54]  K. Pentieva,et al.  Panel on Dietetic Products, Nutrition and Allergies (NDA) , 2012 .

[55]  B. Hollis,et al.  Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. , 1999, The journal of nutrition, health & aging.