Osteoarthritis: a narrative review of molecular approaches to disease management

[1]  R. Thurlings,et al.  The role of inflammation in mesenchymal stromal cell therapy in osteoarthritis, perspectives for post-traumatic osteoarthritis: a review. , 2021, Rheumatology.

[2]  Hiromu Ito,et al.  A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis , 2020, Scientific Reports.

[3]  E. McCarty,et al.  A Systematic Review of Basic Science and Animal Studies on the Use of Doxycycline to Reduce the Risk of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Rupture/Transection , 2020, The American journal of sports medicine.

[4]  F. Watt Posttraumatic osteoarthritis: what have we learned to advance osteoarthritis? , 2020, Current opinion in rheumatology.

[5]  A. Haudenschild,et al.  Bromodomain-containing-protein-4 and cyclin-dependent-kinase-9 inhibitors interact synergistically in vitro and combined treatment reduces post-traumatic osteoarthritis severity in mice. , 2020, Osteoarthritis and cartilage.

[6]  D. Fenyö,et al.  Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis , 2020, Scientific Reports.

[7]  A. Sudo,et al.  Intra-articular injection of rebamipide prevents articular cartilage degeneration in murine post-traumatic osteoarthritis models , 2020, Modern rheumatology.

[8]  E. Blain,et al.  AMPA/Kainate glutamate receptor antagonists prevent post-traumatic osteoarthritis. , 2020, JCI insight.

[9]  S. Grässel,et al.  Recent advances in the treatment of osteoarthritis , 2020, F1000Research.

[10]  Ni Zeng,et al.  Post-traumatic osteoarthritis following ACL injury , 2020, Arthritis Research & Therapy.

[11]  S. Rodeo,et al.  Matrix Metalloproteinase Inhibition With Doxycycline Affects the Progression of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Rupture: Evaluation in a New Nonsurgical Murine ACL Rupture Model , 2019, The American journal of sports medicine.

[12]  Felix Eckstein,et al.  Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial. , 2019, JAMA.

[13]  C. Wang,et al.  Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway , 2019, Arthritis Research & Therapy.

[14]  S. Mertens,et al.  SANRA—a scale for the quality assessment of narrative review articles , 2019, Research integrity and peer review.

[15]  E. Schwarz,et al.  Attenuated Joint Tissue Damage Associated With Improved Synovial Lymphatic Function Following Treatment With Bortezomib in a Mouse Model of Experimental Posttraumatic Osteoarthritis , 2019, Arthritis & rheumatology.

[16]  R. LaPrade,et al.  High Rates of Osteoarthritis Develop After Anterior Cruciate Ligament Surgery: An Analysis of 4108 Patients , 2018, The American journal of sports medicine.

[17]  G. Loots,et al.  SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury , 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[18]  L. Bonassar,et al.  Mitoprotective therapy preserves chondrocyte viability and prevents cartilage degeneration in an ex vivo model of posttraumatic osteoarthritis , 2018, Journal of Orthopaedic Research.

[19]  P. Stadnik,et al.  Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non‐invasive murine model of post‐traumatic osteoarthritis , 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[20]  Haibo Cong,et al.  Sivelestat sodium hydrate improves post-traumatic knee osteoarthritis through nuclear factor-κB in a rat model , 2017, Experimental and therapeutic medicine.

[21]  Abbey C. Thomas,et al.  Epidemiology of Posttraumatic Osteoarthritis. , 2017, Journal of athletic training.

[22]  O. Kennedy,et al.  Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression , 2017, Nature Communications.

[23]  Yang Wang,et al.  Intra‐articular dexamethasone to inhibit the development of post‐traumatic osteoarthritis , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[24]  A. Ignatius,et al.  Antioxidative therapy in an ex vivo human cartilage trauma-model: attenuation of trauma-induced cell loss and ECM-destructive enzymes by N-acetyl cysteine. , 2016, Osteoarthritis and cartilage.

[25]  A. Pozzi,et al.  Integrin α1β1 protects against signs of post-traumatic osteoarthritis in the female murine knee partially via regulation of epidermal growth factor receptor signalling. , 2016, Osteoarthritis and cartilage.

[26]  L. Punzi,et al.  Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation , 2016, RMD Open.

[27]  T. Patel,et al.  Extracellular matrix‐blood composite injection reduces post‐traumatic osteoarthritis after anterior cruciate ligament injury in the rat , 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[28]  C. Frank,et al.  Single intra‐articular dexamethasone injection immediately post‐surgery in a rabbit model mitigates early inflammatory responses and post‐traumatic osteoarthritis‐like alterations , 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[29]  C. Scanzello,et al.  Inflammation in joint injury and post-traumatic osteoarthritis. , 2015, Osteoarthritis and cartilage.

[30]  F. Guilak,et al.  Non-invasive mouse models of post-traumatic osteoarthritis. , 2015, Osteoarthritis and cartilage.

[31]  F. Guilak,et al.  Therapeutic opportunities to prevent post‐traumatic arthritis: Lessons from the natural history of arthritis after articular fracture , 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[32]  J. García-Sancho,et al.  Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial , 2015, Transplantation.

[33]  T. Sasho,et al.  Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration , 2015, Scientific Reports.

[34]  B. Christiansen,et al.  Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice , 2015, Arthritis Research & Therapy.

[35]  Weikai Zhang,et al.  Bortezomib prevents the expression of MMP-13 and the degradation of collagen type 2 in human chondrocytes. , 2014, Biochemical and biophysical research communications.

[36]  F. Guilak,et al.  Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis , 2014, Arthritis Research & Therapy.

[37]  L. Xing,et al.  Distribution and Alteration of Lymphatic Vessels in Knee Joints of Normal and Osteoarthritic Mice , 2014, Arthritis & rheumatology.

[38]  D. Hunter,et al.  Pathogenesis of post-traumatic OA with a view to intervention. , 2014, Best practice & research. Clinical rheumatology.

[39]  D. Hunter,et al.  Post-traumatic osteoarthritis: from mouse models to clinical trials , 2013, Nature Reviews Rheumatology.

[40]  M. Wimmer,et al.  Key Pathways to Prevent Posttraumatic Arthritis for Future Molecule-Based Therapy , 2013, Cartilage.

[41]  T. Liu,et al.  Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage , 2010 .

[42]  M. Doschak,et al.  Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. , 2012, Osteoarthritis and cartilage.

[43]  S. Goldring,et al.  Osteoarthritis: a disease of the joint as an organ. , 2012, Arthritis and rheumatism.

[44]  W. Garrett,et al.  Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254). , 2012, Osteoarthritis and cartilage.

[45]  L. Laslett,et al.  Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial , 2012, Annals of the rheumatic diseases.

[46]  M. Doherty,et al.  History of knee injuries and knee osteoarthritis: a meta-analysis of observational studies. , 2011, Osteoarthritis and cartilage.

[47]  M. Uddin,et al.  Potentiation of pro-inflammatory cytokine suppression and survival by microencapsulated dexamethasone in the treatment of experimental sepsis , 2011, Journal of drug targeting.

[48]  Takashi Nakamura,et al.  Chondroprotective effect of alendronate in a rabbit model of osteoarthritis , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[49]  E. Ling,et al.  Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia , 2011, BMC Neuroscience.

[50]  F. Blanco,et al.  The role of mitochondria in osteoarthritis , 2011, Nature Reviews Rheumatology.

[51]  M. Lotz New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options , 2010, Arthritis research & therapy.

[52]  T. Kirita,et al.  Mechanical stretch enhances NF-kappaB-dependent gene expression and poly(ADP-ribose) synthesis in synovial cells. , 2010, Journal of biochemistry.

[53]  Charles Pudrith,et al.  Glucocorticoids reduce nitric oxide concentration in middle ear effusion from lipopolysaccharide induced otitis media. , 2010, International journal of pediatric otorhinolaryngology.

[54]  N. Ishiguro,et al.  Regulation of prostaglandin E2 synthesis in cells derived from chondrocytes of patients with osteoarthritis , 2009, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[55]  B. Hintermann,et al.  Etiology of Ankle Osteoarthritis , 2009, Clinical orthopaedics and related research.

[56]  D. Loeuille,et al.  Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. , 2009, Arthritis and rheumatism.

[57]  E. Roos,et al.  The Long-term Consequence of Anterior Cruciate Ligament and Meniscus Injuries , 2007, The American journal of sports medicine.

[58]  Thomas D Brown,et al.  Posttraumatic Osteoarthritis: A First Estimate of Incidence, Prevalence, and Burden of Disease , 2006, Journal of orthopaedic trauma.

[59]  M. Macdonald,et al.  Endogenously produced adenosine regulates articular cartilage matrix homeostasis: enzymatic depletion of adenosine stimulates matrix degradation. , 2004, Osteoarthritis and cartilage.

[60]  L. Duong,et al.  The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. , 2004, Arthritis and rheumatism.

[61]  Frank P Barry,et al.  Stem cell therapy in a caprine model of osteoarthritis. , 2003, Arthritis and rheumatism.

[62]  S. Cook,et al.  Repair of Articular Cartilage Defects with Osteogenic Protein-1 (BMP-7) in Dogs , 2003, The Journal of bone and joint surgery. American volume.

[63]  I. Heyligers,et al.  Use of recombinant human osteogenic protein-1 for the repair of subchondral defects in articular cartilage in goats. , 2000, Journal of biomedical materials research.

[64]  L. Setton,et al.  Progress in intra-articular therapy , 2014, Nature Reviews Rheumatology.

[65]  M. Lotz,et al.  Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options , 2010 .

[66]  J. Buckwalter,et al.  Epidemiology of ankle arthritis: report of a consecutive series of 639 patients from a tertiary orthopaedic center. , 2005, The Iowa orthopaedic journal.

[67]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..