Mechanisms of cholestasis.

[1]  Joanna Girling,et al.  Intrahepatic cholestasis of pregnancy , 2022, BJOG : an international journal of obstetrics and gynaecology.

[2]  J. Boyer,et al.  Molecular pathogenesis of cholestasis. , 2012, The New England journal of medicine.

[3]  H. Fukui,et al.  Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases , 2008, Journal of gastroenterology and hepatology.

[4]  K. Zatloukal,et al.  Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis , 2007, Liver international : official journal of the International Association for the Study of the Liver.

[5]  F. Lammert,et al.  Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. , 2007, Gastroenterology.

[6]  M. Trauner,et al.  Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. , 2007, Biochimica et biophysica acta.

[7]  M. Trauner,et al.  MDR3 (ABCB4) defects: a paradigm for the genetics of adult cholestatic syndromes. , 2007, Seminars in liver disease.

[8]  T. Wienker,et al.  Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy , 2007, Hepatology.

[9]  P. Meier,et al.  Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury , 2007, Pharmacogenetics and genomics.

[10]  P. Meier,et al.  Hepatobiliary transporters and drug‐induced cholestasis , 2006, Hepatology.

[11]  J. Boyer,et al.  Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes. , 2006, Gastroenterology.

[12]  L. Mattsson,et al.  Intrahepatic cholestasis of pregnancy: the severe form is associated with common variants of the hepatobiliary phospholipid transporter ABCB4 gene , 2006, Gut.

[13]  D. Häussinger,et al.  Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy. , 2006, Gastroenterology.

[14]  Richard J. Thompson,et al.  Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency , 2006, Hepatology.

[15]  L. Pawlikowska,et al.  Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport , 2006, Hepatology.

[16]  M. Trauner,et al.  Molecular mechanisms of cholestasis , 2006, Wiener Medizinische Wochenschrift.

[17]  Rick Moore,et al.  Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity* , 2006, Journal of Biological Chemistry.

[18]  A. Floreani,et al.  Intrahepatic cholestasis of pregnancy: three novel MDR3 gene mutations , 2006, Alimentary pharmacology & therapeutics.

[19]  J. Marin,et al.  Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy. , 2006, Journal of hepatology.

[20]  M. Trauner,et al.  Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. , 2006, Molecular pharmaceutics.

[21]  K. Lazaridis,et al.  Genetics of hepatobiliary diseases. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[22]  H. Denk,et al.  Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[23]  K. Aittomäki,et al.  Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: A population‐based study , 2006, Hepatology.

[24]  David A. Taylor,et al.  Safe Harbor: Protecting Ports with Shipboard Fuel Cells , 2006, Environmental health perspectives.

[25]  M. Trauner,et al.  Fxr−/− mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids Published, JLR Papers in Press, December 4, 2005. , 2006, Journal of Lipid Research.

[26]  C. Paulusma,et al.  Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases. , 2006, Gastroenterology.

[27]  P. Dawson,et al.  OSTα‐OSTβ: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia , 2005 .

[28]  S. Taylor-Robinson,et al.  ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy , 2005, Gut.

[29]  D. Keppler,et al.  Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis , 2005, Hepatology.

[30]  V. Balan,et al.  Lack of Association of Common Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations with Primary Sclerosing Cholangitis , 2005, The American Journal of Gastroenterology.

[31]  P. Dawson,et al.  The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter* , 2005, Journal of Biological Chemistry.

[32]  U. Diczfalusy,et al.  Novel pathways of bile acid metabolism involving CYP3A4. , 2005, Biochimica et biophysica acta.

[33]  G. Kullak-Ublick,et al.  Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism. , 2005, Archives of biochemistry and biophysics.

[34]  K. Faber,et al.  LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[35]  N. LaRusso,et al.  The cholangiopathies: disorders of biliary epithelia. , 2004, Gastroenterology.

[36]  A. Smahi,et al.  Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease. , 2004, Gastroenterology.

[37]  R. Houwen,et al.  Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11. , 2004, Gastroenterology.

[38]  R. Yantiss,et al.  Induction of colitis in cftr-/- mice results in bile duct injury. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[39]  H. Tilg,et al.  Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. , 2004, Gastroenterology.

[40]  J. Boyer,et al.  Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. , 2004, Journal of hepatology.

[41]  P. Boelle,et al.  ABCB4 gene mutations and primary sclerosing cholangitis. , 2004, Gastroenterology.

[42]  C. Liddle,et al.  Feed-forward Regulation of Bile Acid Detoxification by CYP3A4 , 2004, Journal of Biological Chemistry.

[43]  P. Meier,et al.  BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis , 2004, Hepatology.

[44]  J. Chiang Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms. , 2004, Journal of hepatology.

[45]  F. Lammert,et al.  From genotypes to haplotypes in hepatobiliary diseases: One plus one equals (sometimes) more than two , 2004, Hepatology.

[46]  P. Meier,et al.  Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. , 2004, Pharmacogenetics.

[47]  M. Arrese,et al.  Is intrahepatic cholestasis of pregnancy an MDR3-related disease? , 2003, Gastroenterology.

[48]  C. Handschin,et al.  Induction of Drug Metabolism: The Role of Nuclear Receptors , 2003, Pharmacological Reviews.

[49]  E. Elias,et al.  Obstetric cholestasis with elevated gamma glutamyl transpeptidase: Incidence, presentation and treatment , 2003, Journal of gastroenterology and hepatology.

[50]  D. Keppler,et al.  Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. , 2003, Journal of hepatology.

[51]  M. Vore,et al.  Biliary Secretion of Glutathione in Estradiol 17β-d-Glucuronide-Induced Cholestasis , 2003, Journal of Pharmacology and Experimental Therapeutics.

[52]  K. Zatloukal,et al.  Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. , 2003, Journal of hepatology.

[53]  L. Klomp,et al.  Progressive familial intrahepatic cholestasis type 1 and extrahepatic features: no catch-up of stature growth, exacerbation of diarrhea, and appearance of liver steatosis after liver transplantation. , 2003, Journal of hepatology.

[54]  C. Gartung,et al.  Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis , 2003, Hepatology.

[55]  P. Boelle,et al.  ABCB4 gene mutation-associated cholelithiasis in adults. , 2003, Gastroenterology.

[56]  Jingsong Cao,et al.  Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[57]  K. Aittomäki,et al.  Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy , 2003, Gut.

[58]  L. Tsui,et al.  Increased prevalence of CFTR mutations and variants and decreased chloride secretion in primary sclerosing cholangitis , 2003, Human Genetics.

[59]  K. Zatloukal,et al.  Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis. , 2003, Journal of hepatology.

[60]  W. Lim,et al.  Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT , 2003, Nature Genetics.

[61]  J. Boyer,et al.  Bile salt transporters: molecular characterization, function, and regulation. , 2003, Physiological reviews.

[62]  J. Prieto,et al.  A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis. , 2003, Gastroenterology.

[63]  K. Zatloukal,et al.  Role of nuclear bile salt receptors Fxr and Pxr in mediating adaptive hepatobiliary transporter response to cholic acid (CA) in mouse liver , 2003 .

[64]  M. McCarthy,et al.  ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy , 2003, Journal of medical genetics.

[65]  K. Feingold,et al.  Repression of Farnesoid X Receptor during the Acute Phase Response* , 2003, The Journal of Biological Chemistry.

[66]  N. LaRusso,et al.  Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes. , 2003, Gastroenterology.

[67]  C. Andres,et al.  A second heterozygous MDR3 nonsense mutation associated with intrahepatic cholestasis of pregnancy , 2003, Journal of medical genetics.

[68]  J. Boyer,et al.  Down-regulation of the Na+/taurocholate cotransporting polypeptide during pregnancy in the rat. , 2003, Journal of hepatology.

[69]  P. Meier,et al.  Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat. , 2003, Biochimica et biophysica acta.

[70]  A. Mannermaa,et al.  Multidrug resistance 3 gene mutation 1712delT and estrogen receptor alpha gene polymorphisms in Finnish women with obstetric cholestasis. , 2002, European journal of obstetrics, gynecology, and reproductive biology.

[71]  B. Stieger,et al.  Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice. , 2002, Journal of hepatology.

[72]  F. Lammert,et al.  Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles. , 2002, Gastroenterology.

[73]  P. Meier,et al.  Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy. , 2002, American journal of physiology. Gastrointestinal and liver physiology.

[74]  R. Poupon,et al.  Contribution of mrp2 in alterations of canalicular bile formation by the endothelin antagonist bosentan. , 2002, Journal of hepatology.

[75]  C. Cazeneuve,et al.  Cystic fibrosis transmembrane conductance regulator (CFTR) gene defects in patients with primary sclerosing cholangitis. , 2002, Journal of hepatology.

[76]  D. Keppler,et al.  Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. , 2002, Biochemical pharmacology.

[77]  D. Keppler,et al.  Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes , 2002, Nature Genetics.

[78]  Jingsong Cao,et al.  Altered localization and activity of canalicular Mrp2 in estradiol‐17β‐D‐glucuronide–induced cholestasis , 2002, Hepatology.

[79]  J. Neuberger,et al.  Defective regulation of cholangiocyte Cl−/HCO−3 and Na+/H+ exchanger activities in primary biliary cirrhosis , 2002, Hepatology.

[80]  S. Karpen Nuclear receptor regulation of hepatic function. , 2002, Journal of hepatology.

[81]  M. Haussler,et al.  Vitamin D Receptor As an Intestinal Bile Acid Sensor , 2002, Science.

[82]  K. Feingold,et al.  Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. , 2002, Biochemical and biophysical research communications.

[83]  E. Gabazza,et al.  Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice. , 2002, American journal of physiology. Gastrointestinal and liver physiology.

[84]  R. Houwen,et al.  Benign recurrent intrahepatic cholestasis progressing to progressive familial intrahepatic cholestasis: low GGT cholestasis is a clinical continuum. , 2002, Journal of hepatology.

[85]  F. Russel,et al.  The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. , 2002, Journal of the American Society of Nephrology : JASN.

[86]  J. Boyer,et al.  Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. , 2001, Gastroenterology.

[87]  Y. Sugiyama,et al.  The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function. , 2001 .

[88]  R. Evans,et al.  Nuclear receptors and lipid physiology: opening the X-files. , 2001, Science.

[89]  R. Sokol,et al.  Cholangiocyte Biology and Cystic Fibrosis Liver Disease , 2001, Seminars in liver disease.

[90]  E. Jacquemin Role of Multidrug Resistance 3 Deficiency in Pediatric and Adult Liver Disease: One Gene for Three Diseases , 2001, Seminars in liver disease.

[91]  Jatinder Lamba,et al.  Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450* , 2001, The Journal of Biological Chemistry.

[92]  U. Beuers,et al.  Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis. , 2001, Liver.

[93]  F. Di Virgilio,et al.  Proinflammatory cytokines inhibit secretion in rat bile duct epithelium. , 2001, Gastroenterology.

[94]  F. Lammert,et al.  Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. , 2001, Gastroenterology.

[95]  T. Kawaguchi,et al.  Alterations in tight junctions differ between primary biliary cirrhosis and primary sclerosing cholangitis , 2001, Hepatology.

[96]  P. Bosma,et al.  The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood. , 2001, Gastroenterology.

[97]  O. Rosmorduc,et al.  MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. , 2001, Gastroenterology.

[98]  J. Boyer,et al.  Cellular localization and up‐regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver , 2001, Hepatology.

[99]  Jürg Reichen,et al.  The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions , 2001, Clinical pharmacology and therapeutics.

[100]  D. Keppler,et al.  Up‐regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver , 2001, Hepatology.

[101]  T. Willson,et al.  The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[102]  R. Evans,et al.  An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[103]  C. Funk,et al.  Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. , 2001, Molecular pharmacology.

[104]  K. Zatloukal,et al.  Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases , 2001, Hepatology.

[105]  M W Whitehead,et al.  The causes of obvious jaundice in South West Wales: perceptions versus reality , 2001, Gut.

[106]  N. Grishin,et al.  Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. , 2000, Science.

[107]  F. Lammert,et al.  Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. , 2000, Journal of hepatology.

[108]  G. Szakács,et al.  MDR3 P-glycoprotein, a Phosphatidylcholine Translocase, Transports Several Cytotoxic Drugs and Directly Interacts with Drugs as Judged by Interference with Nucleotide Trapping* , 2000, The Journal of Biological Chemistry.

[109]  K. Feingold,et al.  The Acute Phase Response Is Associated with Retinoid X Receptor Repression in Rodent Liver* , 2000, The Journal of Biological Chemistry.

[110]  M. McCarthy,et al.  Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. , 2000, Human molecular genetics.

[111]  Y. Sugiyama,et al.  Characterization of inducible nature of MRP3 in rat liver. , 2000, American journal of physiology. Gastrointestinal and liver physiology.

[112]  P. Meier,et al.  Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. , 2000, Gastroenterology.

[113]  Kazuhide Yamamoto,et al.  Cytokine Profile in the Liver of Primary Biliary Cirrhosis , 1999, Journal of Clinical Immunology.

[114]  Walter E. Gall,et al.  Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7 , 1999, The Journal of Steroid Biochemistry and Molecular Biology.

[115]  J. Martí-Climent,et al.  Assessment of biliary bicarbonate secretion in humans by positron emission tomography. , 1999, Gastroenterology.

[116]  J. Boyer,et al.  Molecular regulation of hepatocellular transport systems in cholestasis. , 1999, Journal of hepatology.

[117]  D. Keppler,et al.  Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma. , 1999, Journal of the American Society of Nephrology : JASN.

[118]  K. Wikvall,et al.  6α-Hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes , 1999 .

[119]  A. Wolkoff,et al.  Characterization of the mechanisms involved in the gender differences in hepatic taurocholate uptake. , 1999, American journal of physiology. Gastrointestinal and liver physiology.

[120]  M. Hadchouel,et al.  Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy , 1999, The Lancet.

[121]  G. Hooiveld,et al.  Up‐regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down‐regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver , 1998, Hepatology.

[122]  Richard J. Thompson,et al.  A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis , 1998, Nature Genetics.

[123]  Y. Sugiyama,et al.  Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. , 1998, Molecular pharmacology.

[124]  J. Boyer,et al.  Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. , 1998, The Journal of clinical investigation.

[125]  N. Freimer,et al.  A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis , 1998, Nature Genetics.

[126]  P. Bosma,et al.  Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[127]  D. Beier,et al.  Regulation of hepatocyte bile salt transporters during hepatic regeneration. , 1997, The American journal of physiology.

[128]  J. Ribalta,et al.  Profiles of bile acids and progesterone metabolites in the urine and serum of women with intrahepatic cholestasis of pregnancy. , 1997, Journal of hepatology.

[129]  D. Keppler,et al.  The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. , 1997, Gastroenterology.

[130]  M. Kool,et al.  A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin‐Johnson syndrome , 1997, Hepatology.

[131]  G. Mieli-Vergani,et al.  Hepatic basolateral sodium‐dependent–bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia , 1997, Hepatology.

[132]  C. Falany Enzymology of human cytosolic sulfotransferases , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[133]  J. Prieto,et al.  Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis , 1997, Hepatology.

[134]  A. Groen,et al.  The role of mdr2 P‐glycoprotein in hepatobiliary lipid transport , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[135]  R. Weinshilboum,et al.  Sulfotransferase molecular biology: cDNAs and genes , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[136]  C. Gartung,et al.  Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters. , 1996, The American journal of physiology.

[137]  P. Dawson,et al.  Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum. , 1996, The American journal of physiology.

[138]  C. Hunt,et al.  Survey of cystic fibrosis transmembrane conductance regulator genotypes in primary sclerosing cholangitis , 1996, Digestive Diseases and Sciences.

[139]  J. Prieto,et al.  Anion exchanger immunoreactivity in human salivary glands in health and Sjögren's syndrome. , 1995, The American journal of pathology.

[140]  J. Dufour,et al.  Nitric oxide blocks bile canalicular contraction by inhibiting inositol trisphosphate-dependent calcium mobilization. , 1995, Gastroenterology.

[141]  N. LaRusso,et al.  Isolation of the microtubule-vesicle motor kinesin from rat liver: selective inhibition by cholestatic bile acids. , 1995, Gastroenterology.

[142]  A. Groen,et al.  Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis. , 1994, The American journal of pathology.

[143]  P. Borst,et al.  Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease , 1993, Cell.

[144]  J. Prieto,et al.  Abnormal expression of anion exchanger genes in primary biliary cirrhosis. , 1993, Gastroenterology.

[145]  D. Chen,et al.  Transcriptional regulatory elements for basal expression of cytochrome P450IIC genes. , 1992, The Journal of biological chemistry.

[146]  N. Tanaka,et al.  Altered bile acid metabolism in liver disease: concurrent occurrence of C-1 and C-6 hydroxylated bile acid metabolites and their preferential excretion into urine. , 1990, Journal of lipid research.

[147]  L. Tsui,et al.  Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. , 1989, Science.

[148]  M. Kaplan,et al.  Primary Biliary Cirrhosis , 1987, The New England journal of medicine.

[149]  S. Poucell,et al.  Mechanisms of cholestasis. , 1986, Laboratory investigation; a journal of technical methods and pathology.

[150]  U. Gundert-Remy,et al.  Biliary and urinary excretion of sulfated, glucuronidated and tetrahydroxylated bile acids in cirrhotic patients , 1985, Hepatology.

[151]  A. Hofmann,et al.  Altered bile acid metabolism in primary biliary cirrhosis , 1981, Digestive Diseases and Sciences.

[152]  G. Burckhardt,et al.  Sodium-coupled taurocholate transport in the proximal convolution of the rat kidney in vivo and in vitro. , 1981, The Journal of clinical investigation.

[153]  R. Vonk,et al.  Lithocholate cholestasis—Sulfated glycolithocholate-induced intrahepatic cholestasis in rats , 1981 .

[154]  J. Sjövall,et al.  Hydroxylation of cholic, chenodeoxycholic, and deoxycholic acids in patients with intrahepatic cholestasis. , 1980, Journal of lipid research.

[155]  J. Sjövall,et al.  Analysis of bile acid glucuronides in urine. Identification of 3α,6α,12α-trihydroxy-5β-cholanoic acid , 1980 .

[156]  M. Vore,et al.  Characterization of cholestasis induced by estradiol-17 beta-D-glucuronide in the rat. , 1980, The Journal of pharmacology and experimental therapeutics.

[157]  F. Schaffner,et al.  Pericanalicular hepatocytic and bile ductular microfilaments in cholestasis in man. , 1980, The American journal of pathology.

[158]  J. Boyer,et al.  Chlorpromazine and its metabolites alter polymerization and gelation of actin. , 1979, Science.

[159]  P. Thomassen Urinary bile acids in late pregnancy and in recurrent cholestasis of pregnancy , 1979, European journal of clinical investigation.

[160]  J. Sjövall,et al.  Bile acid profiles in urine of patients with liver diseases , 1979, European journal of clinical investigation.

[161]  J. Sjövall,et al.  Analysis of metabolic profiles of bile acids in urine using a lipophilic anion exchanger and computerized gas-liquid chromatorgaphy-mass spectrometry. , 1977, Journal of lipid research.

[162]  W. Fröhling,et al.  [Morphologic studies on the toxicity of sulfated and nonsulfated lithocholic acid in the isolation-perfused rat liver]. , 1977, Zeitschrift fur Gastroenterologie.

[163]  G. P. van Berge Henegouwen,et al.  Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. , 1976, Gut.

[164]  W. Fröhling Bile Salt Glucuronides: Identification and Quantitative Analysis in the Urine of Patients with Cholestasis , 1976, European journal of clinical investigation.

[165]  I. Makino,et al.  Sulfated and nonsulfated bile acids in urine, serum, and bile of patients with hepatobiliary diseases. , 1975, Gastroenterology.

[166]  J. Sjövall,et al.  Steroid sulphates in plasma from pregnant women with pruritus and elevated plasma bile acid levels. , 1970, Annals of clinical research.

[167]  S. Sookoian,et al.  Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy. , 2008, Journal of hepatology.

[168]  H. Bernstein,et al.  Bile acids as carcinogens in human gastrointestinal cancers. , 2005, Mutation research.

[169]  M. Hiltunen,et al.  Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy. , 2003, Scandinavian journal of gastroenterology.

[170]  K. Zatloukal,et al.  Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice. , 2002, American journal of physiology. Gastrointestinal and liver physiology.

[171]  Anand K. Srivastava,et al.  Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption , 2001, Nature Genetics.

[172]  J. Boyer,et al.  Molecular Alterations in Hepatocyte Transport Mechanisms in Acquired Cholestatic Liver Disorders , 2000, Seminars in liver disease.

[173]  I. Arias,et al.  Intracellular Trafficking and Regulation of Canalicular ATP-Binding Cassette Transporters , 2000, Seminars in liver disease.

[174]  P. Meier,et al.  Decreased Na+-dependent taurocholate uptake and low expression of the sinusoidal Na+-taurocholate cotransporting protein (Ntcp) in livers of mdr2 P-glycoprotein-deficient mice. , 1999, Journal of hepatology.

[175]  R. W. Daniel,et al.  Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. , 1998, American journal of physiology. Gastrointestinal and liver physiology.

[176]  R. Moseley Sepsis-associated cholestasis. , 1997, Gastroenterology.

[177]  V. Desmet Vanishing bile duct syndrome in drug-induced liver disease. , 1997, Journal of hepatology.

[178]  J. Boyer,et al.  Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. , 1996, Gastroenterology.

[179]  Y. Bacq,et al.  Serum conjugated bile acid profile during intrahepatic cholestasis of pregnancy. , 1995, Journal of hepatology.

[180]  V. McKusick,et al.  Byler Disease: Fatal Familial Intrahepatic Cholestasis in an Amish Kindred , 1969 .