Prenylated p-Terphenyls from a Mangrove Endophytic Fungus, Aspergillus candidus LDJ-5.

Nine previously undescribed prenylated p-terphenyls, prenylterphenyllins F-J (1, 2, 4-6) and prenylcandidusins D-G (3, 7-9), were isolated from an endophytic fungus, Aspergillus candidus LDJ-5. Their structures were determined from NMR and MS data. Differing from previously reported p-terphenyls, compound 3 represents a rare 6,5,6,6-fused ring system. Compounds 4-6 are antimicrobial, and compounds 1, 4, 6, and 9 are cytotoxic.

[1]  Yun Gao,et al.  Cytotoxic p-Terphenyls from the Endolichenic Fungus Floricola striata. , 2018, Journal of natural products.

[2]  H. Lou,et al.  Structural and biological diversity of natural p-terphenyls , 2018, Journal of Asian natural products research.

[3]  N. Boonyuen,et al.  Terphenyl derivatives and drimane - Phathalide/isoindolinones from Hypoxylon fendleri BCC32408. , 2017, Phytochemistry.

[4]  Zhi-kai Guo,et al.  New p-terphenyls from the endophytic fungus Aspergillus sp. YXf3. , 2017, Bioorganic & medicinal chemistry letters.

[5]  Lin Li,et al.  p-Terphenyl Derivatives from the Endolichenic Fungus Floricola striata. , 2016, Journal of natural products.

[6]  R. Müller,et al.  Rickenyls A-E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota). , 2015, Phytochemistry.

[7]  Hongwei Liu,et al.  Two sarcoviolins with antioxidative and α-glucosidase inhibitory activity from the edible mushroom Sarcodon leucopus collected in Tibet. , 2014, Journal of natural products.

[8]  K. Nishio,et al.  Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex. , 2014, Journal of natural products.

[9]  Yuemao Shen,et al.  p-Terphenyl O-β-glucuronides, DNA topoisomerase inhibitors from Streptomyces sp. LZ35ΔgdmAI. , 2014, Bioorganic & medicinal chemistry letters.

[10]  Zhi-kai Guo,et al.  p-Terphenyl and diterpenoid metabolites from endophytic Aspergillus sp. YXf3. , 2012, Journal of natural products.

[11]  Yongjun Lu,et al.  Azaphilones and p-terphenyls from the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2) isolated from the South China Sea. , 2011, Journal of natural products.

[12]  S. Cai,et al.  Prenylated Polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07. , 2011, Journal of natural products.

[13]  Weiming Zhu,et al.  Cytotoxic polyketides from a marine-derived fungus Aspergillus glaucus. , 2008, Journal of natural products.

[14]  Motomasa Kobayashi,et al.  Prenylterphenyllin and Its Dehydroxyl Analogs, New Cytotoxic Substances from a Marine-derived Fungus Aspergillus candidus IF10 , 2007, The Journal of Antibiotics.

[15]  Jikai Liu.  Natural terphenyls: developments since 1877. , 2006, Chemical reviews.

[16]  N. L. Taylor,et al.  Isolation and characterisation of a prenylated p-terphenyl metabolite of Aspergillus candidus possessing potent and selective cytotoxic activity; studies on mechanism of action. , 1999, The Journal of antibiotics.

[17]  J. Gloer,et al.  New p-terphenyl and polyketide metabolites from the sclerotia of Penicillium raistrickii. , 1998, Journal of natural products.

[18]  Oh,et al.  Arenarins A-C: new cytotoxic fungal metabolites from the sclerotia of aspergillus arenarius , 1998, Journal of natural products.

[19]  I. Yoo,et al.  Betulinans A and B, two benzoquinone compounds from Lenzites betulina. , 1996, Journal of natural products.