YAM (DIOSCOREA ALATA) INHIBITS HYPERTRIGLYCERIDEMIA AND LIVER ENLARGEMENT IN RATS WITH HYPERCHOLESTEROL DIET

Attempts were made to elucidate the effect of yam (Dioscorea alata) on the hypercholesterol diet. Twenty-four male Wistar rats were used and treated with corn oil, high dose of cholesterol (10%) and yam (40%). It was found that excess cholesterol and yam resulted in a stimulatory effect on the growth of rats. The enlargement of liver increased after 2 weeks with treatment of excess cholesterol (p＜0.05). Such symptom was prevented in the group supplemented with yam. The level of triglyceride and cholesterol in the plasma of rats was significantly reduced by yam, even when rats were treated with excess cholesterol at the same time. The activity of plasma aspartate transaminase (AST) and alanine transaminase (ALT) were significantly increased as soon as rats were treated with excess cholesterol and yam in the 1-2 weeks. However, such activity was not observed when the rats were only treated with excess cholesterol for 4-8 weeks. These data demonstrated that yam might inhibit the acute induction of hypertriglyceridemia and liver enlargement in hypercholesterol diet rats.

[1]  Chen-Tien Chang,et al.  Effects of Taiwanese yam (Dioscorea japonica Thunb var. pseudojaponica Yamamoto) on upper gut function and lipid metabolism in Balb/c mice. , 2003, Nutrition.

[2]  Chen-Tien Chang,et al.  Effects of Taiwanese yam (Dioscorea alata L. cv. Tainung No. 2) on the mucosal hydrolase activities and lipid metabolism in Balb/c mice , 2003 .

[3]  Shih-Chang Lee,et al.  Effects of "Chinese yam" on hepato-nephrotoxicity of acetaminophen in rats. , 2002, Acta pharmacologica Sinica.

[4]  V. Vuksan,et al.  Fiber in the Treatment of Hyperlipidemia , 2001 .

[5]  D. Illingworth,et al.  Management of hypercholesterolemia. , 2001, The Medical clinics of North America.

[6]  J. Dietschy.  Theoretical considerations of what regulates low-density-lipoprotein and high-density-lipoprotein cholesterol. , 1997, The American journal of clinical nutrition.

[7]  M. Liebman,et al.  Impact of different dietary fatty acids on plasma and liver lipids is influenced by dietary cholesterol in rats , 1996 .

[8]  D. Klurfeld.  CRC Handbook of Dietary Fiber in Human Nutrition, 2nd Ed. , 1994 .

[9]  F. Parhami,et al.  Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. , 1993, The Journal of clinical investigation.

[10]  R. Coleman,et al.  Effect of diosgenin on biliary cholesterol transport in the rat. , 1993, The Biochemical journal.

[11]  V. Ord,et al.  Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans. , 1992, The American journal of pathology.

[12]  D. Steinberg,et al.  Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[13]  A. Goldberg,et al.  Efficacy and safety of pravastatin in patients with primary hypercholesterolemia. II. Once-daily versus twice-daily dosing. , 1990, Atherosclerosis.

[14]  A. J. Valente,et al.  Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[15]  A. Lusis,et al.  Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins , 1990, Nature.

[16]  M. Manjunath,et al.  Chemical composition of mucilage of Chinese yam , 1990 .

[17]  F. Sacks,et al.  Effect of a modified, well-tolerated niacin regimen on serum total cholesterol, high density lipoprotein cholesterol and the cholesterol to high density lipoprotein ratio. , 1989, The American journal of cardiology.

[18]  J L Witztum,et al.  Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. , 1989, The Journal of clinical investigation.

[19]  M. H. Luria,et al.  Effect of low-dose niacin on high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol ratio. , 1988, Archives of internal medicine.

[20]  K. Uchida,et al.  Changes in biliary and fecal bile acids in mice after treatments with diosgenin and beta-sitosterol. , 1984, Journal of lipid research.

[21]  O. Onayemi,et al.  PREPARATION AND STORAGE PROPERTIES OF DRUM DRIED WHITE YAM (Dioscorea rotundata Poir) FLAKES , 1974 .

[22]  C. Demigné,et al.  Low levels of viscous hydrocolloids lower plasma cholesterol in rats primarily by impairing cholesterol absorption. , 2000, The Journal of nutrition.

[23]  B. McCrindle,et al.  Effect of gemfibrozil in men with primary isolated low high-density lipoprotein cholesterol: a randomized, double-blind, placebo-controlled, crossover study. , 1993, The American journal of medicine.

[24]  O. Onayemi.  Some Chemical Factors Affecting the Quality of Processed Yam , 1986 .